[article] 
inAutism > 23-3 (April 2019) . - p.783-791

Titre :	Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Yi-Ling CHIEN, Auteur ; Miao-Churn CHOU, Auteur ; W. J. CHOU, Auteur ; Y. Y. WU, Auteur ; W. C. TSAI, Auteur ; Yen-Nan CHIU, Auteur ; S. S. GAU, Auteur
Article en page(s) :	p.783-791
Langues :	Anglais (eng)
Mots-clés :	autism spectrum disorder  perinatal  prenatal  sibling  symptom
Index. décimale :	PER Périodiques
Résumé :	Prenatal and perinatal factors may increase the risk of autism spectrum disorder. However, little is known about whether unaffected siblings of probands with autism spectrum disorder also share the phenomenon and whether the prenatal/perinatal factors are related to the clinical severity of autistic symptoms. We compared the frequency of prenatal and perinatal factors among 323 probands with autism spectrum disorder (mean age +/- standard deviation, 10.7 +/- 3.5 years; males, 91.0%), 257 unaffected siblings (11.7 +/- 4.5; 42.8%), and 1504 typically developing controls (8.9 +/- 1.6 years; 53.1%); and investigated their effects on the severity of autistic symptoms. We found that probands with autism spectrum disorder and their unaffected siblings had more prenatal/perinatal events than typically developing controls with higher numbers of prenatal/perinatal factors in probands than in unaffected siblings. The prenatal/perinatal events were associated with greater stereotyped behaviors, social-emotional problems, socio-communication deficits, and overall severity. We also found that six prenatal/perinatal factors (i.e. preeclampsia, polyhydramnios, oligoamnios, placenta previa, umbilical cord knot, and gestational diabetes) were associated with the severity of autistic symptoms, particularly stereotyped behaviors and socio-communication deficits. Our findings suggest that prenatal and perinatal factors may potentially moderate the clinical expression of autism spectrum disorder. The underlying mechanism warrants further research.
En ligne :	http://dx.doi.org/10.1177/1362361318772813
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392

[article] Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder [Texte imprimé et/ou numérique] / Yi-Ling CHIEN, Auteur ; Miao-Churn CHOU, Auteur ; W. J. CHOU, Auteur ; Y. Y. WU, Auteur ; W. C. TSAI, Auteur ; Yen-Nan CHIU, Auteur ; S. S. GAU, Auteur . - p.783-791.
Langues : Anglais (eng)
in Autism > 23-3 (April 2019) . - p.783-791

Mots-clés :	autism spectrum disorder  perinatal  prenatal  sibling  symptom
Index. décimale :	PER Périodiques
Résumé :	Prenatal and perinatal factors may increase the risk of autism spectrum disorder. However, little is known about whether unaffected siblings of probands with autism spectrum disorder also share the phenomenon and whether the prenatal/perinatal factors are related to the clinical severity of autistic symptoms. We compared the frequency of prenatal and perinatal factors among 323 probands with autism spectrum disorder (mean age +/- standard deviation, 10.7 +/- 3.5 years; males, 91.0%), 257 unaffected siblings (11.7 +/- 4.5; 42.8%), and 1504 typically developing controls (8.9 +/- 1.6 years; 53.1%); and investigated their effects on the severity of autistic symptoms. We found that probands with autism spectrum disorder and their unaffected siblings had more prenatal/perinatal events than typically developing controls with higher numbers of prenatal/perinatal factors in probands than in unaffected siblings. The prenatal/perinatal events were associated with greater stereotyped behaviors, social-emotional problems, socio-communication deficits, and overall severity. We also found that six prenatal/perinatal factors (i.e. preeclampsia, polyhydramnios, oligoamnios, placenta previa, umbilical cord knot, and gestational diabetes) were associated with the severity of autistic symptoms, particularly stereotyped behaviors and socio-communication deficits. Our findings suggest that prenatal and perinatal factors may potentially moderate the clinical expression of autism spectrum disorder. The underlying mechanism warrants further research.
En ligne :	http://dx.doi.org/10.1177/1362361318772813
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392