Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study / Yong Zhang ; Fang Xie ; Sheng LI ; Ying LI ; Liting Yang ; Zhen Wang ; Jinlin Lei ; Huailan Guo in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.427-436 Titre : Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Yong Zhang, Auteur ; Fang Xie, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting Yang, Auteur ; Zhen Wang, Auteur ; Jinlin Lei, Auteur ; Huailan Guo, Auteur Article en page(s) : p.427-436 Langues : Anglais (eng) Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case-Control Study : Autism Research [Texte imprimé et/ou numérique] / Yong Zhang, Auteur ; Fang Xie, Auteur ; Sheng LI, Auteur ; Ying LI, Auteur ; Liting Yang, Auteur ; Zhen Wang, Auteur ; Jinlin Lei, Auteur ; Huailan Guo, Auteur . - p.427-436. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.427-436 Mots-clés : autism spectrum disorder Bayesian kernel machine regression model mediation oxidative stress trace element Index. décimale : PER Périodiques Résumé : ABSTRACT Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case?control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges. En ligne : https://doi.org/10.1002/aur.3302 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Reward learning modulates the attentional processing of faces in children with and without autism spectrum disorder / Tianbi LI in Autism Research, 10-11 (November 2017)  

Public ISBD [article]  inAutism Research > 10-11 (November 2017) . - p.1797-1807 Titre : Reward learning modulates the attentional processing of faces in children with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tianbi LI, Auteur ; Xueqin WANG, Auteur ; Junhao PAN, Auteur ; Shuyuan FENG, Auteur ; Mengyuan GONG, Auteur ; Yaxue WU, Auteur ; Guoxiang LI, Auteur ; Sheng LI, Auteur ; Li YI, Auteur Article en page(s) : p.1797-1807 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  reward learning  face recognition  attention  visual search  face processing Index. décimale : PER Périodiques Résumé : The processing of social stimuli, such as human faces, is impaired in individuals with autism spectrum disorder (ASD), which could be accounted for by their lack of social motivation. The current study examined how the attentional processing of faces in children with ASD could be modulated by the learning of face-reward associations. Sixteen high-functioning children with ASD and 20 age- and ability-matched typically developing peers participated in the experiments. All children started with a reward learning task, in which the children were presented with three female faces that were attributed with positive, negative, and neutral values, and were required to remember the faces and their associated values. After this, they were tested on the recognition of the learned faces and a visual search task in which the learned faces served as the distractor. We found a modulatory effect of the face-reward associations on the visual search but not the recognition performance in both groups despite the lower efficacy among children with ASD in learning the face-reward associations. Specifically, both groups responded faster when one of the distractor faces was associated with positive or negative values than when the distractor face was neutral, suggesting an efficient attentional processing of these reward-associated faces. Our findings provide direct evidence for the perceptual-level modulatory effect of reward learning on the attentional processing of faces in individuals with ASD. Autism Res 2017, 10: 1797–1807. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary In our study, we tested whether the face processing of individuals with ASD could be changed when the faces were associated with different social meanings. We found no effect of social meanings on face recognition, but both groups responded faster in the visual search task when one of the distractor faces was associated with positive or negative values than when the neutral face. The findings suggest that children with ASD could efficiently process faces associated with different values like typical children. En ligne : http://dx.doi.org/10.1002/aur.1823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 [article] Reward learning modulates the attentional processing of faces in children with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Tianbi LI, Auteur ; Xueqin WANG, Auteur ; Junhao PAN, Auteur ; Shuyuan FENG, Auteur ; Mengyuan GONG, Auteur ; Yaxue WU, Auteur ; Guoxiang LI, Auteur ; Sheng LI, Auteur ; Li YI, Auteur . - p.1797-1807. Langues : Anglais (eng) in Autism Research > 10-11 (November 2017) . - p.1797-1807 Mots-clés : autism spectrum disorder  reward learning  face recognition  attention  visual search  face processing Index. décimale : PER Périodiques Résumé : The processing of social stimuli, such as human faces, is impaired in individuals with autism spectrum disorder (ASD), which could be accounted for by their lack of social motivation. The current study examined how the attentional processing of faces in children with ASD could be modulated by the learning of face-reward associations. Sixteen high-functioning children with ASD and 20 age- and ability-matched typically developing peers participated in the experiments. All children started with a reward learning task, in which the children were presented with three female faces that were attributed with positive, negative, and neutral values, and were required to remember the faces and their associated values. After this, they were tested on the recognition of the learned faces and a visual search task in which the learned faces served as the distractor. We found a modulatory effect of the face-reward associations on the visual search but not the recognition performance in both groups despite the lower efficacy among children with ASD in learning the face-reward associations. Specifically, both groups responded faster when one of the distractor faces was associated with positive or negative values than when the distractor face was neutral, suggesting an efficient attentional processing of these reward-associated faces. Our findings provide direct evidence for the perceptual-level modulatory effect of reward learning on the attentional processing of faces in individuals with ASD. Autism Res 2017, 10: 1797–1807. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary In our study, we tested whether the face processing of individuals with ASD could be changed when the faces were associated with different social meanings. We found no effect of social meanings on face recognition, but both groups responded faster in the visual search task when one of the distractor faces was associated with positive or negative values than when the neutral face. The findings suggest that children with ASD could efficiently process faces associated with different values like typical children. En ligne : http://dx.doi.org/10.1002/aur.1823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322

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