[article]
| Titre : |
Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Elaine Y. HSIAO, Auteur ; Paul H. PATTERSON, Auteur |
| Article en page(s) : |
6 p. |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Several of the environmental stimuli suggested to play a role in the pathogenesis of ASD involve altered immune responses during gestation. In this review, we discuss maternal immune activation as a primary risk factor for ASD, with an emphasis on recent findings from animal models of prenatal immune challenges. We further address the presence of autoantibodies as an additional immune-related autism risk factor, drawing upon work done in rodent and monkey models. We then explore the intersection between genetic and environmental susceptibility, with a focus on gene-environment interactions and immune involvement, in genetic risk factors for autism. Finally, we provide emerging evidence for the role of immune dysregulation in the pathogenesis of ASD. |
| En ligne : |
https://dx.doi.org/10.4172/2165-7890.S1-003 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 |
in Autism - Open Access > 2-S [01/12/2012] . - 6 p.
[article] Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models [Texte imprimé et/ou numérique] / Elaine Y. HSIAO, Auteur ; Paul H. PATTERSON, Auteur . - 6 p. Langues : Anglais ( eng) in Autism - Open Access > 2-S [01/12/2012] . - 6 p.
| Index. décimale : |
PER Périodiques |
| Résumé : |
Several of the environmental stimuli suggested to play a role in the pathogenesis of ASD involve altered immune responses during gestation. In this review, we discuss maternal immune activation as a primary risk factor for ASD, with an emphasis on recent findings from animal models of prenatal immune challenges. We further address the presence of autoantibodies as an additional immune-related autism risk factor, drawing upon work done in rodent and monkey models. We then explore the intersection between genetic and environmental susceptibility, with a focus on gene-environment interactions and immune involvement, in genetic risk factors for autism. Finally, we provide emerging evidence for the role of immune dysregulation in the pathogenesis of ASD. |
| En ligne : |
https://dx.doi.org/10.4172/2165-7890.S1-003 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 |
|
Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models in Autism - Open Access, 2-S ([01/12/2012])
