Dépouillements

Where are the autism economists? / Anthony J. BAILEY in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.245 Titre : Where are the autism economists? Type de document : Texte imprimé et/ou numérique Auteurs : Anthony J. BAILEY, Auteur Année de publication : 2009 Article en page(s) : p.245 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.99 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] Where are the autism economists? [Texte imprimé et/ou numérique] / Anthony J. BAILEY, Auteur . - 2009 . - p.245. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.245 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.99 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder / Julia A. SCOTT in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.246-257 Titre : A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur Année de publication : 2009 Article en page(s) : p.246-257 Langues : Anglais (eng) Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur . - 2009 . - p.246-257. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.246-257 Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

Identification of chromosome 7 inversion breakpoints in an autistic family narrows candidate region for autism susceptibility / Holly N. CUKIER in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.258-266 Titre : Identification of chromosome 7 inversion breakpoints in an autistic family narrows candidate region for autism susceptibility Type de document : Texte imprimé et/ou numérique Auteurs : Holly N. CUKIER, Auteur ; Michael L. CUCCARO, Auteur ; John R. GILBERT, Auteur ; Margaret A. O. PERICAK-VANCE, Auteur ; David A. SKAAR, Auteur ; Melissa Y. RAYNER-EVANS, Auteur ; Ioanna KONIDARI, Auteur ; Patrice L. WHITEHEAD, Auteur ; James M. JAWORSKI, Auteur Année de publication : 2009 Article en page(s) : p.258-266 Langues : Anglais (eng) Mots-clés : molecular-genetics paracentric-inversion fluorescent-in-situ-hybridization-(FISH) genome-wide-association-study-(GWAS) Index. décimale : PER Périodiques Résumé : Chromosomal breaks and rearrangements have been observed in conjunction with autism and autistic spectrum disorders. A chromosomal inversion has been previously reported in autistic siblings, spanning the region from approximately 7q22.1 to 7q31. This family is distinguished by having multiple individuals with autism and associated disabilities. The region containing the inversion has been strongly implicated in autism by multiple linkage studies, and has been particularly associated with language defects in autism as well as in other disorders with language components. Mapping of the inversion breakpoints by FISH has localized the inversion to the region spanning approximately 99-108.75 Mb of chromosome 7. The proximal breakpoint has the potential to disrupt either the coding sequence or regulatory regions of a number of cytochrome P450 genes while the distal region falls in a relative gene desert. Copy number variant analysis of the breakpoint regions detected no duplication or deletion that could clearly be associated with disease status. Association analysis in our autism data set using single nucleotide polymorphisms located near the breakpoints showed no significant association with proximal breakpoint markers, but has identified markers near the distal breakpoint (108-110 Mb) with significant associations to autism. The chromosomal abnormality in this family strengthens the case for an autism susceptibility gene in the chromosome 7q22-31 region and targets a candidate region for further investigation. En ligne : http://dx.doi.org/10.1002/aur.96 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] Identification of chromosome 7 inversion breakpoints in an autistic family narrows candidate region for autism susceptibility [Texte imprimé et/ou numérique] / Holly N. CUKIER, Auteur ; Michael L. CUCCARO, Auteur ; John R. GILBERT, Auteur ; Margaret A. O. PERICAK-VANCE, Auteur ; David A. SKAAR, Auteur ; Melissa Y. RAYNER-EVANS, Auteur ; Ioanna KONIDARI, Auteur ; Patrice L. WHITEHEAD, Auteur ; James M. JAWORSKI, Auteur . - 2009 . - p.258-266. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.258-266 Mots-clés : molecular-genetics paracentric-inversion fluorescent-in-situ-hybridization-(FISH) genome-wide-association-study-(GWAS) Index. décimale : PER Périodiques Résumé : Chromosomal breaks and rearrangements have been observed in conjunction with autism and autistic spectrum disorders. A chromosomal inversion has been previously reported in autistic siblings, spanning the region from approximately 7q22.1 to 7q31. This family is distinguished by having multiple individuals with autism and associated disabilities. The region containing the inversion has been strongly implicated in autism by multiple linkage studies, and has been particularly associated with language defects in autism as well as in other disorders with language components. Mapping of the inversion breakpoints by FISH has localized the inversion to the region spanning approximately 99-108.75 Mb of chromosome 7. The proximal breakpoint has the potential to disrupt either the coding sequence or regulatory regions of a number of cytochrome P450 genes while the distal region falls in a relative gene desert. Copy number variant analysis of the breakpoint regions detected no duplication or deletion that could clearly be associated with disease status. Association analysis in our autism data set using single nucleotide polymorphisms located near the breakpoints showed no significant association with proximal breakpoint markers, but has identified markers near the distal breakpoint (108-110 Mb) with significant associations to autism. The chromosomal abnormality in this family strengthens the case for an autism susceptibility gene in the chromosome 7q22-31 region and targets a candidate region for further investigation. En ligne : http://dx.doi.org/10.1002/aur.96 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

Gyrification patterns in monozygotic twin pairs varying in discordance for autism / Wendy R. KATES in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.267-278 Titre : Gyrification patterns in monozygotic twin pairs varying in discordance for autism Type de document : Texte imprimé et/ou numérique Auteurs : Wendy R. KATES, Auteur ; Courtney BURNETTE, Auteur ; Ichiro IKUTA, Auteur Année de publication : 2009 Article en page(s) : p.267-278 Langues : Anglais (eng) Mots-clés : Autism twins cortical-gyrification MRI brain Index. décimale : PER Périodiques Résumé : In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism. En ligne : http://dx.doi.org/10.1002/aur.98 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] Gyrification patterns in monozygotic twin pairs varying in discordance for autism [Texte imprimé et/ou numérique] / Wendy R. KATES, Auteur ; Courtney BURNETTE, Auteur ; Ichiro IKUTA, Auteur . - 2009 . - p.267-278. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.267-278 Mots-clés : Autism twins cortical-gyrification MRI brain Index. décimale : PER Périodiques Résumé : In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism. En ligne : http://dx.doi.org/10.1002/aur.98 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

Prototype formation in autism: Can individuals with autism abstract facial prototypes? / Holly ZAJAC GASTGEB in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.279-284 Titre : Prototype formation in autism: Can individuals with autism abstract facial prototypes? Type de document : Texte imprimé et/ou numérique Auteurs : Holly ZAJAC GASTGEB, Auteur ; Nancy J. MINSHEW, Auteur ; Keiran M. RUMP, Auteur ; Catherine A. BEST, Auteur ; Mark S. STRAUSS, Auteur Année de publication : 2009 Article en page(s) : p.279-284 Langues : Anglais (eng) Mots-clés : prototype autism categorization face-perception Index. décimale : PER Périodiques Résumé : Prototype formation is a critical skill for category learning. Research suggests that individuals with autism may have a deficit in prototype formation of some objects; however, results are mixed. This study used a natural category, faces, to further examine prototype formation in high-functioning individuals with autism. High-functioning children (age 8-13 years) and adults with autism (age 17-53 years) and matched controls were tested in a facial prototype formation task that has been used to test prototype formation abilities in typically developing infants and adults [Strauss, [1979]]. Participants were familiarized to a series of faces depicting subtle variations in the spatial distance of facial features, and were then given a forced choice familiarity test between the mean prototype and the mode prototype. Overall, individuals in the autism group were significantly less likely to select the mean prototype face. Even though the children with autism showed this difference in prototype formation, this pattern was driven primarily by the adults, because the adults with autism were approximately four times less likely to select the mean prototype than were the control adults. These results provide further evidence that individuals with autism have difficulty abstracting subtle spatial information that is necessary not only for the formation of a mean prototype, but also for categorizing faces and objects. En ligne : http://dx.doi.org/10.1002/aur.93 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] Prototype formation in autism: Can individuals with autism abstract facial prototypes? [Texte imprimé et/ou numérique] / Holly ZAJAC GASTGEB, Auteur ; Nancy J. MINSHEW, Auteur ; Keiran M. RUMP, Auteur ; Catherine A. BEST, Auteur ; Mark S. STRAUSS, Auteur . - 2009 . - p.279-284. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.279-284 Mots-clés : prototype autism categorization face-perception Index. décimale : PER Périodiques Résumé : Prototype formation is a critical skill for category learning. Research suggests that individuals with autism may have a deficit in prototype formation of some objects; however, results are mixed. This study used a natural category, faces, to further examine prototype formation in high-functioning individuals with autism. High-functioning children (age 8-13 years) and adults with autism (age 17-53 years) and matched controls were tested in a facial prototype formation task that has been used to test prototype formation abilities in typically developing infants and adults [Strauss, [1979]]. Participants were familiarized to a series of faces depicting subtle variations in the spatial distance of facial features, and were then given a forced choice familiarity test between the mean prototype and the mode prototype. Overall, individuals in the autism group were significantly less likely to select the mean prototype face. Even though the children with autism showed this difference in prototype formation, this pattern was driven primarily by the adults, because the adults with autism were approximately four times less likely to select the mean prototype than were the control adults. These results provide further evidence that individuals with autism have difficulty abstracting subtle spatial information that is necessary not only for the formation of a mean prototype, but also for categorizing faces and objects. En ligne : http://dx.doi.org/10.1002/aur.93 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

Gastrointestinal symptoms in ASD, brain structure of identical twins with ASD / Edwin H. Jr COOK in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.285-286 Titre : Gastrointestinal symptoms in ASD, brain structure of identical twins with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2009 Article en page(s) : p.285-286 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.95 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939 [article] Gastrointestinal symptoms in ASD, brain structure of identical twins with ASD [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2009 . - p.285-286. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.285-286 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.95 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939

Lay abstracts in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.287-288 Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.287-288 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939 [article] Lay abstracts [Texte imprimé et/ou numérique] . - 2009 . - p.287-288. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.287-288 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939

The International Meeting for Autism Research in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.289-290 Titre : The International Meeting for Autism Research Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.289-290 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.105 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939 [article] The International Meeting for Autism Research [Texte imprimé et/ou numérique] . - 2009 . - p.289-290. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.289-290 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.105 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939

International Society for Autism Research News in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.291 Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.291 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939 [article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2009 . - p.291. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.291 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=939