Neural correlates of communication skill and symptom severity in autism: A voxel-based morphometry study / Lauren K. PARKS in Research in Autism Spectrum Disorders, 3-2 (April-june 2009)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 3-2 (April-june 2009) . - p.444-454 Titre : Neural correlates of communication skill and symptom severity in autism: A voxel-based morphometry study Type de document : Texte imprimé et/ou numérique Auteurs : Lauren K. PARKS, Auteur ; Dina E. HILL, Auteur ; Robert J. THOMA, Auteur ; Matthew J. EULER, Auteur ; Jeffrey D. LEWINE, Auteur ; Ronald A. YEO, Auteur Année de publication : 2009 Article en page(s) : p.444-454 Langues : Anglais (eng) Mots-clés : Autism VBM Communication Severity Heterogeneity Index. décimale : PER Périodiques Résumé : Although many studies have compared the brains of normal controls and individuals with autism, especially older, higher-functioning individuals with autism, little is known of the neural correlates of the vast clinical heterogeneity characteristic of the disorder. In this study, we used voxel-based morphometry (VBM) to examine gray matter correlates of variation in communication skill and symptom severity within a heterogeneous group of 33 children with autism ranging in age from 3.4 to 11.4 years. Greater gray matter (GM) volume was associated with better communication skills in numerous frontal regions, especially in the left middle frontal gyrus. Further, greater GM volume in the right inferior frontal gyrus was associated with reduced severity of symptoms of autism. However, increased total GM volume was correlated with more severe symptoms of autism at a trend level, consistent with other studies, suggesting that while increased total GM volume is generally predictive of greater autistic severity, specific local increases in GM volume result in a reduction in symptoms. Our results suggest that communication and symptom severity have distinct neuroanatomic correlates and draw attention to the importance of studying the neuroanatomy of clinical heterogeneity within the autistic population. En ligne : http://dx.doi.org/10.1016/j.rasd.2008.09.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=709 [article] Neural correlates of communication skill and symptom severity in autism: A voxel-based morphometry study [Texte imprimé et/ou numérique] / Lauren K. PARKS, Auteur ; Dina E. HILL, Auteur ; Robert J. THOMA, Auteur ; Matthew J. EULER, Auteur ; Jeffrey D. LEWINE, Auteur ; Ronald A. YEO, Auteur . - 2009 . - p.444-454. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 3-2 (April-june 2009) . - p.444-454 Mots-clés : Autism VBM Communication Severity Heterogeneity Index. décimale : PER Périodiques Résumé : Although many studies have compared the brains of normal controls and individuals with autism, especially older, higher-functioning individuals with autism, little is known of the neural correlates of the vast clinical heterogeneity characteristic of the disorder. In this study, we used voxel-based morphometry (VBM) to examine gray matter correlates of variation in communication skill and symptom severity within a heterogeneous group of 33 children with autism ranging in age from 3.4 to 11.4 years. Greater gray matter (GM) volume was associated with better communication skills in numerous frontal regions, especially in the left middle frontal gyrus. Further, greater GM volume in the right inferior frontal gyrus was associated with reduced severity of symptoms of autism. However, increased total GM volume was correlated with more severe symptoms of autism at a trend level, consistent with other studies, suggesting that while increased total GM volume is generally predictive of greater autistic severity, specific local increases in GM volume result in a reduction in symptoms. Our results suggest that communication and symptom severity have distinct neuroanatomic correlates and draw attention to the importance of studying the neuroanatomy of clinical heterogeneity within the autistic population. En ligne : http://dx.doi.org/10.1016/j.rasd.2008.09.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=709

Predictors of Treatment Outcome in Young Children with Autism: A Retrospective Study / Robin GABRIELS in Autism, 5-4 (December 2001)  

Public ISBD [article]  inAutism > 5-4 (December 2001) . - p.407-429 Titre : Predictors of Treatment Outcome in Young Children with Autism: A Retrospective Study Type de document : Texte imprimé et/ou numérique Auteurs : Robin GABRIELS, Auteur ; Dina E. HILL, Auteur ; Rebecca A. PIERCE, Auteur ; Sally J ROGERS, Auteur ; Beth WEHNER, Auteur Article en page(s) : p.407-429 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined predictors of developmental outcomes in 17 children diagnosed with autism or PDD-NOS, who received generic treatment over a mean period of 37 months. Pre-treatment evaluations occurred at a mean age of 31 months with follow-up evaluations at a mean age of 69 months. Significantly different developmental trajectories were observed among the participants at follow-up, separating the participants into two distinct groups (high and low outcome). However, groups did not differ significantly in treatment intensity or other outcome prediction measures. Pre-treatment developmental intelligence levels between the two groups approached significance. The results raise questions regarding the effect of treatment intensity and type, family stress factors, and intelligence ability in very early childhood on, outcome. En ligne : http://dx.doi.org/10.1177/1362361301005004006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209 [article] Predictors of Treatment Outcome in Young Children with Autism: A Retrospective Study [Texte imprimé et/ou numérique] / Robin GABRIELS, Auteur ; Dina E. HILL, Auteur ; Rebecca A. PIERCE, Auteur ; Sally J ROGERS, Auteur ; Beth WEHNER, Auteur . - p.407-429. Langues : Anglais (eng) in Autism > 5-4 (December 2001) . - p.407-429 Index. décimale : PER Périodiques Résumé : This study examined predictors of developmental outcomes in 17 children diagnosed with autism or PDD-NOS, who received generic treatment over a mean period of 37 months. Pre-treatment evaluations occurred at a mean age of 31 months with follow-up evaluations at a mean age of 69 months. Significantly different developmental trajectories were observed among the participants at follow-up, separating the participants into two distinct groups (high and low outcome). However, groups did not differ significantly in treatment intensity or other outcome prediction measures. Pre-treatment developmental intelligence levels between the two groups approached significance. The results raise questions regarding the effect of treatment intensity and type, family stress factors, and intelligence ability in very early childhood on, outcome. En ligne : http://dx.doi.org/10.1177/1362361301005004006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209

Stability of adaptive behaviors in middle-school children with autism spectrum disorders / Robin GABRIELS in Research in Autism Spectrum Disorders, 1-4 (October/December 2007)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 1-4 (October/December 2007) . - p.291-303 Titre : Stability of adaptive behaviors in middle-school children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Robin GABRIELS, Auteur ; John MCNEILL, Auteur ; John A. AGNEW, Auteur ; Dina E. HILL, Auteur ; Bonnie Jean IVERS, Auteur Année de publication : 2007 Article en page(s) : p.291-303 Langues : Anglais (eng) Mots-clés : Adaptive-functioning Autism-spectrum-disorders Nonverbal-intelligence Caregiver-stress Intervention Index. décimale : PER Périodiques Résumé : This 5-year follow-up study examined the stability of adaptive functioning in two cognitive ability groups of children with an autism spectrum disorder (ASD). Nonverbal intelligence (NVIQ) was assessed at the time of this study and no participant changed cognitive group membership from the previous study (High NVIQ ≥ 97; Low NVIQ ≤ 56). In each group, adaptive skills, as measured by the Vineland Adaptive Behavior Scales (VABS) composite standard score, were significantly below NVIQ. Both groups exhibited a significant decrease in the VABS composite standard scores over time, but analysis of VABS total raw scores showed a significant increase in adaptive functioning over time in the High NVIQ group with no change in the Low NVIQ group. Examining the profile of VABS age equivalent scores in each NVIQ group revealed potential suggestions for interventionists. Caregivers of the Low NVIQ group endorsed having significantly higher stress levels related to their child's level of adaptive functioning. Groups did not differ significantly in the quantity of treatment received within the 9 months preceding this study or caregiver satisfaction with intervention services. Caregivers from both groups identified a variety of school-based service needs to address their child's adaptive skill deficits. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.11.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=300 [article] Stability of adaptive behaviors in middle-school children with autism spectrum disorders [Texte imprimé et/ou numérique] / Robin GABRIELS, Auteur ; John MCNEILL, Auteur ; John A. AGNEW, Auteur ; Dina E. HILL, Auteur ; Bonnie Jean IVERS, Auteur . - 2007 . - p.291-303. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 1-4 (October/December 2007) . - p.291-303 Mots-clés : Adaptive-functioning Autism-spectrum-disorders Nonverbal-intelligence Caregiver-stress Intervention Index. décimale : PER Périodiques Résumé : This 5-year follow-up study examined the stability of adaptive functioning in two cognitive ability groups of children with an autism spectrum disorder (ASD). Nonverbal intelligence (NVIQ) was assessed at the time of this study and no participant changed cognitive group membership from the previous study (High NVIQ ≥ 97; Low NVIQ ≤ 56). In each group, adaptive skills, as measured by the Vineland Adaptive Behavior Scales (VABS) composite standard score, were significantly below NVIQ. Both groups exhibited a significant decrease in the VABS composite standard scores over time, but analysis of VABS total raw scores showed a significant increase in adaptive functioning over time in the High NVIQ group with no change in the Low NVIQ group. Examining the profile of VABS age equivalent scores in each NVIQ group revealed potential suggestions for interventionists. Caregivers of the Low NVIQ group endorsed having significantly higher stress levels related to their child's level of adaptive functioning. Groups did not differ significantly in the quantity of treatment received within the 9 months preceding this study or caregiver satisfaction with intervention services. Caregivers from both groups identified a variety of school-based service needs to address their child's adaptive skill deficits. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.11.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=300

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