Emotional processing in male adolescents with childhood-onset conduct disorder / Sabine C. HERPERTZ in Journal of Child Psychology and Psychiatry, 49-7 (July 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-7 (July 2008) . - p.781 - 791 Titre : Emotional processing in male adolescents with childhood-onset conduct disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sabine C. HERPERTZ, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Gereon R. FINK, Auteur ; Kerstin KONRAD, Auteur ; Thomas HUEBNER, Auteur ; Ivo MARX, Auteur ; Timo D. VLOET, Auteur ; Tony STOECKER, Auteur ; N. Jon SHAH, Auteur Année de publication : 2008 Article en page(s) : p.781 - 791 Langues : Anglais (eng) Mots-clés : Conduct-disorder fMRI emotion antisocial-behavior amygdala antisocial-personality-disorder Index. décimale : PER Périodiques Résumé : Background: Boys with early onset of conduct disorder (CD), most of whom also meet diagnostic criteria of a comorbid attention deficit hyperactivity disorder (ADHD), tend to exhibit high levels of aggression throughout development. While a number of functional neuroimaging studies on emotional processing have been performed in antisocial adults, little is known about how CD children process emotional information. Method: Functional magnetic resonance imaging data were analyzed in 22 male adolescents aged 12 to 17 years with childhood-onset CD (16 of them with comorbid ADHD) compared to 22 age-matched male healthy controls. In order to consider the likely confounding of results through ADHD comorbidity, we performed a supplementary study including 13 adolescent subjects with pure ADHD who were compared with healthy controls. To challenge emotional processing of stimuli, a passive viewing task was applied, presenting pictures of negative, positive or neutral valence. Results: When comparing CD/combined disorder patients with healthy controls, we found enhanced left-sided amygdala activation in response to negative pictures as compared to neutral pictures in the patient group. In addition, these boys exhibited no reduced activation in the orbitofrontal, anterior cingulate and insular cortices. By contrast, children with pure ADHD did not show any abnormalities in amygdala activation but showed decreased neural activity in the insula only in response to negative pictures. Conclusions: Increased rather than reduced amygdala activation found in our study may indicate an enhanced response to environmental cues in adolescents with early-onset CD (most of whom also met the condition of ADHD), and is not consistent with the assumption of a reduced capacity to take note of affective information in the social environment. Further studies with an emphasis on developmental aspects of affect regulation are needed to clarify the relationship between CD and adult personality pathology associated with different modes of persistent antisocial behavior. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01905.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=541 [article] Emotional processing in male adolescents with childhood-onset conduct disorder [Texte imprimé et/ou numérique] / Sabine C. HERPERTZ, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Gereon R. FINK, Auteur ; Kerstin KONRAD, Auteur ; Thomas HUEBNER, Auteur ; Ivo MARX, Auteur ; Timo D. VLOET, Auteur ; Tony STOECKER, Auteur ; N. Jon SHAH, Auteur . - 2008 . - p.781 - 791. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-7 (July 2008) . - p.781 - 791 Mots-clés : Conduct-disorder fMRI emotion antisocial-behavior amygdala antisocial-personality-disorder Index. décimale : PER Périodiques Résumé : Background: Boys with early onset of conduct disorder (CD), most of whom also meet diagnostic criteria of a comorbid attention deficit hyperactivity disorder (ADHD), tend to exhibit high levels of aggression throughout development. While a number of functional neuroimaging studies on emotional processing have been performed in antisocial adults, little is known about how CD children process emotional information. Method: Functional magnetic resonance imaging data were analyzed in 22 male adolescents aged 12 to 17 years with childhood-onset CD (16 of them with comorbid ADHD) compared to 22 age-matched male healthy controls. In order to consider the likely confounding of results through ADHD comorbidity, we performed a supplementary study including 13 adolescent subjects with pure ADHD who were compared with healthy controls. To challenge emotional processing of stimuli, a passive viewing task was applied, presenting pictures of negative, positive or neutral valence. Results: When comparing CD/combined disorder patients with healthy controls, we found enhanced left-sided amygdala activation in response to negative pictures as compared to neutral pictures in the patient group. In addition, these boys exhibited no reduced activation in the orbitofrontal, anterior cingulate and insular cortices. By contrast, children with pure ADHD did not show any abnormalities in amygdala activation but showed decreased neural activity in the insula only in response to negative pictures. Conclusions: Increased rather than reduced amygdala activation found in our study may indicate an enhanced response to environmental cues in adolescents with early-onset CD (most of whom also met the condition of ADHD), and is not consistent with the assumption of a reduced capacity to take note of affective information in the social environment. Further studies with an emphasis on developmental aspects of affect regulation are needed to clarify the relationship between CD and adult personality pathology associated with different modes of persistent antisocial behavior. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01905.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=541

Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder / Sarah BRIEBER in Journal of Child Psychology and Psychiatry, 48-12 (December 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-12 (December 2007) . - p.1251–1258 Titre : Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah BRIEBER, Auteur ; Susanne NEUFANG, Auteur ; Nicole BRUNING, Auteur ; Inge KAMP-BECKER, Auteur ; Helmut REMSCHMIDT, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Gereon R. FINK, Auteur ; Kerstin KONRAD, Auteur Année de publication : 2007 Article en page(s) : p.1251–1258 Langues : Anglais (eng) Mots-clés : ADD/ADHD autistic-disorder structural-MRI VBM Index. décimale : PER Périodiques Résumé : Background: Although autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) are two distinct neurodevelopmental diseases, they share behavioural, neuropsychological and neurobiological characteristics. For the identification of endophenotypes across diagnostic categories, further investigations of phenotypic overlap between ADHD and autism at the behavioural, neurocognitive, and brain levels are needed. Methods: We examined regional grey matter differences and similarities in children and adolescents with ASD and ADHD in comparison to healthy controls using structural magnetic resonance imaging (MRI) and voxel-based morphometry. Results: With regard to clinical criteria, the clinical groups did not differ with respect to ADHD symptoms; however, only patients with ASD showed deficits in social communication and interaction, according to parental rating. Structural abnormalities across both clinical groups compared to controls became evident as grey matter reductions in the left medial temporal lobe and as higher grey matter volumes in the left inferior parietal cortex. In addition, autism-specific brain abnormalities were found as increased grey matter volume in the right supramarginal gyrus. Conclusions: While the shared structural deviations in the medial temporal lobe might be attributed to an unspecific delay in brain development and might be associated with memory deficits, the structural abnormalities in the inferior parietal lobe may correspond to attentional deficits observed in both ASD and ADHD. By contrast, the autism-specific grey matter abnormalities near the right temporo-parietal junction may be associated with impaired ‘theory of mind’ abilities. These findings shed some light on both similarities and differences in the neurocognitive profiles of ADHD and ASD patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01799.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Sarah BRIEBER, Auteur ; Susanne NEUFANG, Auteur ; Nicole BRUNING, Auteur ; Inge KAMP-BECKER, Auteur ; Helmut REMSCHMIDT, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Gereon R. FINK, Auteur ; Kerstin KONRAD, Auteur . - 2007 . - p.1251–1258. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-12 (December 2007) . - p.1251–1258 Mots-clés : ADD/ADHD autistic-disorder structural-MRI VBM Index. décimale : PER Périodiques Résumé : Background: Although autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) are two distinct neurodevelopmental diseases, they share behavioural, neuropsychological and neurobiological characteristics. For the identification of endophenotypes across diagnostic categories, further investigations of phenotypic overlap between ADHD and autism at the behavioural, neurocognitive, and brain levels are needed. Methods: We examined regional grey matter differences and similarities in children and adolescents with ASD and ADHD in comparison to healthy controls using structural magnetic resonance imaging (MRI) and voxel-based morphometry. Results: With regard to clinical criteria, the clinical groups did not differ with respect to ADHD symptoms; however, only patients with ASD showed deficits in social communication and interaction, according to parental rating. Structural abnormalities across both clinical groups compared to controls became evident as grey matter reductions in the left medial temporal lobe and as higher grey matter volumes in the left inferior parietal cortex. In addition, autism-specific brain abnormalities were found as increased grey matter volume in the right supramarginal gyrus. Conclusions: While the shared structural deviations in the medial temporal lobe might be attributed to an unspecific delay in brain development and might be associated with memory deficits, the structural abnormalities in the inferior parietal lobe may correspond to attentional deficits observed in both ASD and ADHD. By contrast, the autism-specific grey matter abnormalities near the right temporo-parietal junction may be associated with impaired ‘theory of mind’ abilities. These findings shed some light on both similarities and differences in the neurocognitive profiles of ADHD and ASD patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01799.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

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