[article]
| Titre : |
Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MacKinsey A. BACH, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Katherine A. LOVELAND, Auteur |
| Article en page(s) : |
101681 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Spectrum Disorder Glutathione S-transferase (GST) genes ( and ) Mixture analysis Generalized weighted quantile sum regression (gWQS) Heavy metals Jamaica |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Exposure to many environmental chemicals, including metals, often does not occur in isolation, hence requires assessment of the associations between exposure to mixtures of chemicals and human health. Objectives To investigate associations of a metal mixture of lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) in children with autism spectrum disorder (ASD), additively or interactively with each of three glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1). Method Using data from 266 case-control pairs of Jamaican children (2–8 years old), we fitted negative and positive generalized weighted quantile sum (gWQS) regression models to assess the aforementioned associations. Results Based on additive and interactive negative gWQS models adjusted for maternal age, parental education, child’s parish, and seafood consumption, we found inverse associations of the overall mixture score with ASD [MOR (95 % CI) = 0.70 (0.49, 0.99); P? |
| En ligne : |
https://doi.org/10.1016/j.rasd.2020.101681 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 |
in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101681
[article] Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MacKinsey A. BACH, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Katherine A. LOVELAND, Auteur . - 101681. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101681
| Mots-clés : |
Autism Spectrum Disorder Glutathione S-transferase (GST) genes ( and ) Mixture analysis Generalized weighted quantile sum regression (gWQS) Heavy metals Jamaica |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Exposure to many environmental chemicals, including metals, often does not occur in isolation, hence requires assessment of the associations between exposure to mixtures of chemicals and human health. Objectives To investigate associations of a metal mixture of lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) in children with autism spectrum disorder (ASD), additively or interactively with each of three glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1). Method Using data from 266 case-control pairs of Jamaican children (2–8 years old), we fitted negative and positive generalized weighted quantile sum (gWQS) regression models to assess the aforementioned associations. Results Based on additive and interactive negative gWQS models adjusted for maternal age, parental education, child’s parish, and seafood consumption, we found inverse associations of the overall mixture score with ASD [MOR (95 % CI) = 0.70 (0.49, 0.99); P? |
| En ligne : |
https://doi.org/10.1016/j.rasd.2020.101681 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 |
|
Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder in Research in Autism Spectrum Disorders, 79 (November 2020)
