Perceptual metrics of individuals with autism provide evidence for disinhibition / Vinay TANNAN in Autism Research, 1-4 (August 2008)  

Public ISBD [article]  inAutism Research > 1-4 (August 2008) . - p.223-230 Titre : Perceptual metrics of individuals with autism provide evidence for disinhibition Type de document : Texte imprimé et/ou numérique Auteurs : Vinay TANNAN, Auteur ; Grace T. BARANEK, Auteur ; Jameson K. HOLDEN, Auteur ; Zheng ZHANG, Auteur ; Mark A. TOMMERDAHL, Auteur Année de publication : 2008 Article en page(s) : p.223-230 Langues : Anglais (eng) Mots-clés : autism inhibition adaptation habituation amplitude discrimination sensory-discrimination Index. décimale : PER Périodiques Résumé : Adults with autism exhibit inhibitory deficits that are often manifested in behavioral modifications, such as repetitive behaviors, and/or sensory hyper-responsiveness. If such behaviors are the result of a generalized deficiency in inhibitory neurotransmission, then it stands to reason that deficits involving localized cortical-cortical interactions - such as in sensory discrimination tasks - could be detected and quantified. This study exemplifies a newly developed method for quantifying sensory testing metrics. Our novel sensory discrimination tests may provide (a) an effective means for biobehavioral assessment of deficits specific to autism and (b) an efficient and sensitive measure of change following treatment. The sensory discriminative capacity of ten subjects with autism and ten controls was compared both before and after short duration adapting stimuli. Specifically, vibrotactile amplitude discriminative capacity was obtained both in the presence and absence of 1 sec adapting stimuli that were delivered 1 sec prior to the comparison stimuli. Although adaptation had a pronounced effect on the amplitude discriminative capacity of the control subjects, little or no impact was observed on the sensory discriminative capacity of the subjects with autism. This lack of impact of the adapting stimuli on the responses of the subjects with autism was interpreted to be consistent with the reduced GABAergic-mediated inhibition described in previous reports. One significant aspect of this study is that the methods could prove to be a useful and efficient way to detect specific neural deficits and monitor the efficacy of pharmacological or behavioral treatments in autism. En ligne : http://dx.doi.org/10.1002/aur.34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932 [article] Perceptual metrics of individuals with autism provide evidence for disinhibition [Texte imprimé et/ou numérique] / Vinay TANNAN, Auteur ; Grace T. BARANEK, Auteur ; Jameson K. HOLDEN, Auteur ; Zheng ZHANG, Auteur ; Mark A. TOMMERDAHL, Auteur . - 2008 . - p.223-230. Langues : Anglais (eng) in Autism Research > 1-4 (August 2008) . - p.223-230 Mots-clés : autism inhibition adaptation habituation amplitude discrimination sensory-discrimination Index. décimale : PER Périodiques Résumé : Adults with autism exhibit inhibitory deficits that are often manifested in behavioral modifications, such as repetitive behaviors, and/or sensory hyper-responsiveness. If such behaviors are the result of a generalized deficiency in inhibitory neurotransmission, then it stands to reason that deficits involving localized cortical-cortical interactions - such as in sensory discrimination tasks - could be detected and quantified. This study exemplifies a newly developed method for quantifying sensory testing metrics. Our novel sensory discrimination tests may provide (a) an effective means for biobehavioral assessment of deficits specific to autism and (b) an efficient and sensitive measure of change following treatment. The sensory discriminative capacity of ten subjects with autism and ten controls was compared both before and after short duration adapting stimuli. Specifically, vibrotactile amplitude discriminative capacity was obtained both in the presence and absence of 1 sec adapting stimuli that were delivered 1 sec prior to the comparison stimuli. Although adaptation had a pronounced effect on the amplitude discriminative capacity of the control subjects, little or no impact was observed on the sensory discriminative capacity of the subjects with autism. This lack of impact of the adapting stimuli on the responses of the subjects with autism was interpreted to be consistent with the reduced GABAergic-mediated inhibition described in previous reports. One significant aspect of this study is that the methods could prove to be a useful and efficient way to detect specific neural deficits and monitor the efficacy of pharmacological or behavioral treatments in autism. En ligne : http://dx.doi.org/10.1002/aur.34 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=932

Tactile Perception in Adults with Autism: a Multidimensional Psychophysical Study / Carissa J. CASCIO in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.127-137 Titre : Tactile Perception in Adults with Autism: a Multidimensional Psychophysical Study Type de document : Texte imprimé et/ou numérique Auteurs : Carissa J. CASCIO, Auteur ; Grace T. BARANEK, Auteur ; Francis MCGLONE, Auteur ; Stephen FOLGER, Auteur ; Vinay TANNAN, Auteur ; Kevin A. PELPHREY, Auteur ; Gregory ESSICK, Auteur Année de publication : 2008 Article en page(s) : p.127-137 Langues : Anglais (eng) Mots-clés : Autism Sensory Tactile Psychophysics CT-afferents Index. décimale : PER Périodiques Résumé : Although sensory problems, including unusual tactile sensitivity, are heavily associated with autism, there is a dearth of rigorous psychophysical research. We compared tactile sensation in adults with autism to controls on the palm and forearm, the latter innervated by low-threshold unmyelinated afferents subserving a social/affiliative submodality of somatosensation. At both sites, the groups displayed similar thresholds for detecting light touch and innocuous sensations of warmth and cool, and provided similar hedonic ratings of the pleasantness of textures. In contrast, increased sensitivity to vibration was seen in the autism group on the forearm, along with increased sensitivity to thermal pain at both sites. These findings suggest normal perception along with certain areas of enhanced perception in autism, consistent with previous studies. En ligne : http://dx.doi.org/10.1007/s10803-007-0370-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Tactile Perception in Adults with Autism: a Multidimensional Psychophysical Study [Texte imprimé et/ou numérique] / Carissa J. CASCIO, Auteur ; Grace T. BARANEK, Auteur ; Francis MCGLONE, Auteur ; Stephen FOLGER, Auteur ; Vinay TANNAN, Auteur ; Kevin A. PELPHREY, Auteur ; Gregory ESSICK, Auteur . - 2008 . - p.127-137. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.127-137 Mots-clés : Autism Sensory Tactile Psychophysics CT-afferents Index. décimale : PER Périodiques Résumé : Although sensory problems, including unusual tactile sensitivity, are heavily associated with autism, there is a dearth of rigorous psychophysical research. We compared tactile sensation in adults with autism to controls on the palm and forearm, the latter innervated by low-threshold unmyelinated afferents subserving a social/affiliative submodality of somatosensation. At both sites, the groups displayed similar thresholds for detecting light touch and innocuous sensations of warmth and cool, and provided similar hedonic ratings of the pleasantness of textures. In contrast, increased sensitivity to vibration was seen in the autism group on the forearm, along with increased sensitivity to thermal pain at both sites. These findings suggest normal perception along with certain areas of enhanced perception in autism, consistent with previous studies. En ligne : http://dx.doi.org/10.1007/s10803-007-0370-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

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