Are There Enhanced MBP Autoantibodies in Autism? / Jane E. LIBBEY in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332 Titre : Are There Enhanced MBP Autoantibodies in Autism? Type de document : Texte imprimé et/ou numérique Auteurs : Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Article en page(s) : p.324-332 Langues : Anglais (eng) Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318 [article] Are There Enhanced MBP Autoantibodies in Autism? [Texte imprimé et/ou numérique] / Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.324-332. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332 Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318

Autoimmunity and Immunology of Autism / Jane E. LIBBEY

Public ISBD contenu dans New Autism Research Developments / Barbara S. MESMERE Titre : Autoimmunity and Immunology of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Jane E. LIBBEY, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Importance : p.87-107 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=670 contenu dans New Autism Research Developments / Barbara S. MESMERE Autoimmunity and Immunology of Autism [Texte imprimé et/ou numérique] / Jane E. LIBBEY, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.87-107. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=670

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How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? / Nikki J. KIRKMAN in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341 Titre : How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? Type de document : Texte imprimé et/ou numérique Auteurs : Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Article en page(s) : p.333-341 Langues : Anglais (eng) Mots-clés : Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome. En ligne : http://dx.doi.org/10.1007/s10803-007-0398-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318 [article] How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? [Texte imprimé et/ou numérique] / Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.333-341. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341 Mots-clés : Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome. En ligne : http://dx.doi.org/10.1007/s10803-007-0398-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318

Role for antibodies in altering behavior and movement / Jane E. LIBBEY in Autism Research, 3-4 (August 2010)  

Public ISBD [article]  inAutism Research > 3-4 (August 2010) . - p.147-152 Titre : Role for antibodies in altering behavior and movement Type de document : Texte imprimé et/ou numérique Auteurs : Jane E. LIBBEY, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2010 Article en page(s) : p.147-152 Langues : Anglais (eng) Mots-clés : antibody autism chorea humoral-immunity systemic-lupus-erythematosus Index. décimale : PER Périodiques Résumé : At the past meeting of INSAR, the role of autoimmunity was discussed in an educational session. This article summarizes this discussion. In immune-mediated diseases, antibodies can contribute to the pathogenesis of the disease and are sometimes the force that drives the disease process. This concept has not been established for autism. In autoimmune diseases, such as systemic lupus erythematosus (SLE), antibodies are found to react with double-stranded DNA. These antibodies also cross-react with N-methyl-D aspartate receptors. Many SLE patients suffer neurologic syndromes of the central nervous system (CNS). Similarly individuals infected with Group A streptococcus (GAS) have antibodies against the GAS carbohydrate, which cross-react with tubulin and lysoganglioside GM1 on neurons. During the acute stage of infection, GAS-infected patients develop Syndenham chorea where the disease process is driven in part by these cross-reactive antibodies. As the antibody levels decrease, the clinical features of Syndenham chorea resolve. In these two immune-mediated diseases, antibodies clearly play a role in the pathogenesis of the diseases. There are reports that mothers of individuals with autism have antibodies that react with brain proteins and when these antibodies are passively transferred to pregnant non-human primates or rodents the offspring has behavioral and nervous system changes. It is still not clear whether the antibodies found in mothers of individuals with autism actually play a role in the disease. More studies need to be performed to identify the proteins recognized by the antibodies and to determine how these could affect development, behavior and changes within the CNS. En ligne : http://dx.doi.org/10.1002/aur.144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109 [article] Role for antibodies in altering behavior and movement [Texte imprimé et/ou numérique] / Jane E. LIBBEY, Auteur ; Robert S. FUJINAMI, Auteur . - 2010 . - p.147-152. Langues : Anglais (eng) in Autism Research > 3-4 (August 2010) . - p.147-152 Mots-clés : antibody autism chorea humoral-immunity systemic-lupus-erythematosus Index. décimale : PER Périodiques Résumé : At the past meeting of INSAR, the role of autoimmunity was discussed in an educational session. This article summarizes this discussion. In immune-mediated diseases, antibodies can contribute to the pathogenesis of the disease and are sometimes the force that drives the disease process. This concept has not been established for autism. In autoimmune diseases, such as systemic lupus erythematosus (SLE), antibodies are found to react with double-stranded DNA. These antibodies also cross-react with N-methyl-D aspartate receptors. Many SLE patients suffer neurologic syndromes of the central nervous system (CNS). Similarly individuals infected with Group A streptococcus (GAS) have antibodies against the GAS carbohydrate, which cross-react with tubulin and lysoganglioside GM1 on neurons. During the acute stage of infection, GAS-infected patients develop Syndenham chorea where the disease process is driven in part by these cross-reactive antibodies. As the antibody levels decrease, the clinical features of Syndenham chorea resolve. In these two immune-mediated diseases, antibodies clearly play a role in the pathogenesis of the diseases. There are reports that mothers of individuals with autism have antibodies that react with brain proteins and when these antibodies are passively transferred to pregnant non-human primates or rodents the offspring has behavioral and nervous system changes. It is still not clear whether the antibodies found in mothers of individuals with autism actually play a role in the disease. More studies need to be performed to identify the proteins recognized by the antibodies and to determine how these could affect development, behavior and changes within the CNS. En ligne : http://dx.doi.org/10.1002/aur.144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=109

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