[article] 
inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1448-1495

Titre :	Early environmental risk factors for neurodevelopmental disorders – a systematic review of twin and sibling studies
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Torkel CARLSSON, Auteur ; Felix MOLANDER, Auteur ; Mark J. TAYLOR, Auteur ; Ulf JONSSON, Auteur ; Sven BÖLTE, Auteur
Article en page(s) :	p.1448-1495
Langues :	Anglais (eng)
Mots-clés :	confounding factors  environmental exposure  neurodevelopmental disorders  systematic review  twin and sibling studies
Index. décimale :	PER Périodiques
Résumé :	While neurodevelopmental disorders (NDDs) are highly heritable, several environmental risk factors have also been suggested. However, the role of familial confounding is unclear. To shed more light on this, we reviewed the evidence from twin and sibling studies. A systematic review was performed on case control and cohort studies including a twin or sibling within-pair comparison of neurodevelopmental outcomes, with environmental exposures until the sixth birthday. From 7,315 screened abstracts, 140 eligible articles were identified. After adjustment for familial confounding advanced paternal age, low birth weight, birth defects, and perinatal hypoxia and respiratory stress were associated with autism spectrum disorder (ASD), and low birth weight, gestational age and family income were associated with attention-deficit/hyperactivity disorder (ADHD), categorically and dimensionally. Several previously suspected factors, including pregnancy-related factors, were deemed due to familial confounding. Most studies were conducted in North America and Scandinavia, pointing to a global research bias. Moreover, most studies focused on ASD and ADHD. This genetically informed review showed evidence for a range of environmental factors of potential casual significance in NDDs, but also points to a critical need of more genetically informed studies of good quality in the quest of the environmental causes of NDDs.
En ligne :	http://dx.doi.org/10.1017/S0954579420000620
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

[article] Early environmental risk factors for neurodevelopmental disorders – a systematic review of twin and sibling studies [Texte imprimé et/ou numérique] / Torkel CARLSSON, Auteur ; Felix MOLANDER, Auteur ; Mark J. TAYLOR, Auteur ; Ulf JONSSON, Auteur ; Sven BÖLTE, Auteur . - p.1448-1495.
Langues : Anglais (eng)
in Development and Psychopathology > 33-4 (October 2021) . - p.1448-1495

Mots-clés :	confounding factors  environmental exposure  neurodevelopmental disorders  systematic review  twin and sibling studies
Index. décimale :	PER Périodiques
Résumé :	While neurodevelopmental disorders (NDDs) are highly heritable, several environmental risk factors have also been suggested. However, the role of familial confounding is unclear. To shed more light on this, we reviewed the evidence from twin and sibling studies. A systematic review was performed on case control and cohort studies including a twin or sibling within-pair comparison of neurodevelopmental outcomes, with environmental exposures until the sixth birthday. From 7,315 screened abstracts, 140 eligible articles were identified. After adjustment for familial confounding advanced paternal age, low birth weight, birth defects, and perinatal hypoxia and respiratory stress were associated with autism spectrum disorder (ASD), and low birth weight, gestational age and family income were associated with attention-deficit/hyperactivity disorder (ADHD), categorically and dimensionally. Several previously suspected factors, including pregnancy-related factors, were deemed due to familial confounding. Most studies were conducted in North America and Scandinavia, pointing to a global research bias. Moreover, most studies focused on ASD and ADHD. This genetically informed review showed evidence for a range of environmental factors of potential casual significance in NDDs, but also points to a critical need of more genetically informed studies of good quality in the quest of the environmental causes of NDDs.
En ligne :	http://dx.doi.org/10.1017/S0954579420000620
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457