159 recherche sur le mot-clé 'neurodevelopmental disorders'

Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review / Fumi MASUDA in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1614-1629 Titre : Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review Type de document : texte imprimé Auteurs : Fumi MASUDA, Auteur ; Shinichiro NAKAJIMA, Auteur ; Takahiro MIYAZAKI, Auteur ; Ryosuke TARUMI, Auteur ; Kamiyu OGYU, Auteur ; Makoto WADA, Auteur ; Sakiko TSUGAWA, Auteur ; P.E. CROARKIN, Auteur ; Masaru MIMURA, Auteur ; Yoshihiro NODA, Auteur Article en page(s) : p.1614-1629 Langues : Anglais (eng) Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  children and adolescents  neurodevelopmental disorders  repetitive transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders, including autism spectrum disorder, are common in children and adolescents, but treatment strategies remain limited. Although repetitive transcranial magnetic stimulation has been studied for neurodevelopmental disorders, there is no clear consensus on its therapeutic effects. This systematic review examined literature on repetitive transcranial magnetic stimulation for children and adolescents with neurodevelopmental disorders published up to 2018 using the PubMed database. The search identified 264 articles and 14 articles met eligibility criteria. Twelve of these studies used conventional repetitive transcranial magnetic stimulation and two studies used theta burst stimulation. No severe adverse effects were reported in these studies. In patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. In patients with attention deficit/hyperactivity disorder, low-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex and high-frequency repetitive transcranial magnetic stimulation applied to the right dorsolateral prefrontal cortex may target inattention, hyperactivity, and impulsivity. In patients with tic disorders, low-frequency repetitive transcranial magnetic stimulation applied to the bilateral supplementary motor area improved tic symptom severity. This systematic review suggests that repetitive transcranial magnetic stimulation may be a promising intervention for children and adolescents with neurodevelopmental disorders. The results warrant further large randomized controlled trials of repetitive transcranial magnetic stimulation in children with neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1177/1362361318822502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review [texte imprimé] / Fumi MASUDA, Auteur ; Shinichiro NAKAJIMA, Auteur ; Takahiro MIYAZAKI, Auteur ; Ryosuke TARUMI, Auteur ; Kamiyu OGYU, Auteur ; Makoto WADA, Auteur ; Sakiko TSUGAWA, Auteur ; P.E. CROARKIN, Auteur ; Masaru MIMURA, Auteur ; Yoshihiro NODA, Auteur . - p.1614-1629. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1614-1629 Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  children and adolescents  neurodevelopmental disorders  repetitive transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Neurodevelopmental disorders, including autism spectrum disorder, are common in children and adolescents, but treatment strategies remain limited. Although repetitive transcranial magnetic stimulation has been studied for neurodevelopmental disorders, there is no clear consensus on its therapeutic effects. This systematic review examined literature on repetitive transcranial magnetic stimulation for children and adolescents with neurodevelopmental disorders published up to 2018 using the PubMed database. The search identified 264 articles and 14 articles met eligibility criteria. Twelve of these studies used conventional repetitive transcranial magnetic stimulation and two studies used theta burst stimulation. No severe adverse effects were reported in these studies. In patients with autism spectrum disorder, low-frequency repetitive transcranial magnetic stimulation and intermittent theta burst stimulation applied to the dorsolateral prefrontal cortex may have therapeutic effects on social functioning and repetitive behaviors. In patients with attention deficit/hyperactivity disorder, low-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex and high-frequency repetitive transcranial magnetic stimulation applied to the right dorsolateral prefrontal cortex may target inattention, hyperactivity, and impulsivity. In patients with tic disorders, low-frequency repetitive transcranial magnetic stimulation applied to the bilateral supplementary motor area improved tic symptom severity. This systematic review suggests that repetitive transcranial magnetic stimulation may be a promising intervention for children and adolescents with neurodevelopmental disorders. The results warrant further large randomized controlled trials of repetitive transcranial magnetic stimulation in children with neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1177/1362361318822502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Brief Report: Delayed Diagnosis of Treatable Inborn Errors of Metabolism in Children with Autism and Other Neurodevelopmental Disorders / María Elena MÁRQUEZ-CARAVEO in Journal of Autism and Developmental Disorders, 51-6 (June 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2124-2131 Titre : Brief Report: Delayed Diagnosis of Treatable Inborn Errors of Metabolism in Children with Autism and Other Neurodevelopmental Disorders Type de document : texte imprimé Auteurs : María Elena MÁRQUEZ-CARAVEO, Auteur ; Isabel IBARRA-GONZÁLEZ, Auteur ; Rocío RODRÍGUEZ-VALENTÍN, Auteur ; Miguel Ángel RAMÍREZ-GARCÍA, Auteur ; Verónica PÉREZ-BARRÓN, Auteur ; Eduardo LAZCANO-PONCE, Auteur ; Marcela VELA-AMIEVA, Auteur Article en page(s) : p.2124-2131 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Child  Delayed Diagnosis/statistics & numerical data  Female  Humans  Male  Metabolism, Inborn Errors/diagnosis/epidemiology/psychology  Mexico/epidemiology  Neurodevelopmental Disorders/complications  Tandem Mass Spectrometry/methods  Autism spectrum disorders  Inborn errors of metabolism  Intellectual disabilities  Metabolic screening  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The objective of our study was to evaluate the frequency of treatable inborn errors of metabolism (IEM) in a clinical sample of Mexican children and adolescents with neurodevelopmental disorders (NDD). Amino acids and acylcarnitines in blood samples of 51 unrelated children and adolescents were analyzed by tandem mass spectrometry to detect treatable IEM of small molecules. One patient with isovaleric acidemia and autism spectrum disorder (ASD) and another with beta-ketothiolase deficiency and ASD/intellectual disability/attention-deficit/hyperactivity disorder (ADHD) were diagnosed, indicating an IEM frequency of 3.9% (1:26 subjects). The high frequency of treatable IEM indicates the need to perform a minimum metabolic screening as part of the diagnostic approach for patient with NDD, particularly when newborn screening programs are limited to a few disorders. En ligne : http://dx.doi.org/10.1007/s10803-020-04682-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Brief Report: Delayed Diagnosis of Treatable Inborn Errors of Metabolism in Children with Autism and Other Neurodevelopmental Disorders [texte imprimé] / María Elena MÁRQUEZ-CARAVEO, Auteur ; Isabel IBARRA-GONZÁLEZ, Auteur ; Rocío RODRÍGUEZ-VALENTÍN, Auteur ; Miguel Ángel RAMÍREZ-GARCÍA, Auteur ; Verónica PÉREZ-BARRÓN, Auteur ; Eduardo LAZCANO-PONCE, Auteur ; Marcela VELA-AMIEVA, Auteur . - p.2124-2131. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2124-2131 Mots-clés : Adolescent  Autism Spectrum Disorder/complications  Child  Delayed Diagnosis/statistics & numerical data  Female  Humans  Male  Metabolism, Inborn Errors/diagnosis/epidemiology/psychology  Mexico/epidemiology  Neurodevelopmental Disorders/complications  Tandem Mass Spectrometry/methods  Autism spectrum disorders  Inborn errors of metabolism  Intellectual disabilities  Metabolic screening  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The objective of our study was to evaluate the frequency of treatable inborn errors of metabolism (IEM) in a clinical sample of Mexican children and adolescents with neurodevelopmental disorders (NDD). Amino acids and acylcarnitines in blood samples of 51 unrelated children and adolescents were analyzed by tandem mass spectrometry to detect treatable IEM of small molecules. One patient with isovaleric acidemia and autism spectrum disorder (ASD) and another with beta-ketothiolase deficiency and ASD/intellectual disability/attention-deficit/hyperactivity disorder (ADHD) were diagnosed, indicating an IEM frequency of 3.9% (1:26 subjects). The high frequency of treatable IEM indicates the need to perform a minimum metabolic screening as part of the diagnostic approach for patient with NDD, particularly when newborn screening programs are limited to a few disorders. En ligne : http://dx.doi.org/10.1007/s10803-020-04682-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders / Jessica A. JIMÉNEZ in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders Type de document : texte imprimé Auteurs : Jessica A. JIMÉNEZ, Auteur ; Mark J. ZYLKA, Auteur Langues : Anglais (eng) Mots-clés : Animals  Female  Haploinsufficiency  Mice  Neurodevelopmental Disorders/chemically induced/genetics  Phenotype  Pregnancy  Reproducibility of Results  Animal models  Litter effect  Neurodevelopmental disorders  Rigor and reproducibility Index. décimale : PER Périodiques Résumé : Research with rodents is crucial for expanding our understanding of genetic and environmental risk factors for neurodevelopmental disorders (NDD). However, there is growing concern about the number of animal studies that are difficult to replicate, potentially undermining the validity of results. These concerns have prompted funding agencies and academic journals to implement more rigorous standards in an effort to increase reproducibility in research. However, these standards fail to address a major source of variability in rodent research brought on by the "litter effect," the fact that rodents from the same litter are phenotypically more similar to one other than rodents from different litters of the same strain. We show that the litter effect accounts for 30-60% of the variability associated with commonly studied phenotypes, including brain, placenta, and body weight. Moreover, we show how failure to control for litter-to-litter variation can mask a phenotype in Chd8(V986*/+) mice that model haploinsufficiency of CHD8, a high-confidence autism gene. Thus, if not properly controlled, the litter effect has the potential to negatively influence rigor and reproducibility of NDD research. While efforts have been made to educate scientists on the importance of controlling for litter effects in previous publications, our analysis of the recent literature (2015-2020) shows that the vast majority of NDD studies focused on genetic risks, including mutant mouse studies, and environmental risks, such as air pollution and valproic acid exposure, do not correct for litter effects or report information on the number of litters used. We outline best practices to help scientists minimize the impact of litter-to-litter variability and to enhance rigor and reproducibility in future NDD studies using rodent models. En ligne : https://dx.doi.org/10.1186/s11689-020-09353-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders [texte imprimé] / Jessica A. JIMÉNEZ, Auteur ; Mark J. ZYLKA, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Animals  Female  Haploinsufficiency  Mice  Neurodevelopmental Disorders/chemically induced/genetics  Phenotype  Pregnancy  Reproducibility of Results  Animal models  Litter effect  Neurodevelopmental disorders  Rigor and reproducibility Index. décimale : PER Périodiques Résumé : Research with rodents is crucial for expanding our understanding of genetic and environmental risk factors for neurodevelopmental disorders (NDD). However, there is growing concern about the number of animal studies that are difficult to replicate, potentially undermining the validity of results. These concerns have prompted funding agencies and academic journals to implement more rigorous standards in an effort to increase reproducibility in research. However, these standards fail to address a major source of variability in rodent research brought on by the "litter effect," the fact that rodents from the same litter are phenotypically more similar to one other than rodents from different litters of the same strain. We show that the litter effect accounts for 30-60% of the variability associated with commonly studied phenotypes, including brain, placenta, and body weight. Moreover, we show how failure to control for litter-to-litter variation can mask a phenotype in Chd8(V986*/+) mice that model haploinsufficiency of CHD8, a high-confidence autism gene. Thus, if not properly controlled, the litter effect has the potential to negatively influence rigor and reproducibility of NDD research. While efforts have been made to educate scientists on the importance of controlling for litter effects in previous publications, our analysis of the recent literature (2015-2020) shows that the vast majority of NDD studies focused on genetic risks, including mutant mouse studies, and environmental risks, such as air pollution and valproic acid exposure, do not correct for litter effects or report information on the number of litters used. We outline best practices to help scientists minimize the impact of litter-to-litter variability and to enhance rigor and reproducibility in future NDD studies using rodent models. En ligne : https://dx.doi.org/10.1186/s11689-020-09353-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Early manifestations of genetic risk for neurodevelopmental disorders / Ragna Bugge ASKELAND in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819 Titre : Early manifestations of genetic risk for neurodevelopmental disorders Type de document : texte imprimé Auteurs : Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth C. CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål R. NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur Article en page(s) : p.810-819 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with  Hyperactivity/complications/epidemiology/genetics  Autism Spectrum Disorder/complications/epidemiology/genetics  Child  Child, Preschool  Cohort Studies  Female  Humans  Male  Mothers  Neurodevelopmental Disorders/complications/epidemiology/genetics  Risk Factors  Adhd  MoBa  Polygenic risk score  autism  hyperactivity  inattention  language and motor difficulties  neurodevelopmental disorders  repetitive behavior  schizophrenia  social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15 205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18 months, 3, 5 and 8 years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8 years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18 months, motor difficulties at 36 months, and hyperactivity and inattention at 8 years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18 months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Early manifestations of genetic risk for neurodevelopmental disorders [texte imprimé] / Ragna Bugge ASKELAND, Auteur ; Laurie J. HANNIGAN, Auteur ; Helga ASK, Auteur ; Ziada AYORECH, Auteur ; Martin TESLI, Auteur ; Elizabeth C. CORFIELD, Auteur ; Per MAGNUS, Auteur ; Pål R. NJØLSTAD, Auteur ; Ole A. ANDREASSEN, Auteur ; George DAVEY SMITH, Auteur ; Ted REICHBORN-KJENNERUD, Auteur ; Alexandra HAVDAHL, Auteur . - p.810-819. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.810-819 Mots-clés : Attention Deficit Disorder with  Hyperactivity/complications/epidemiology/genetics  Autism Spectrum Disorder/complications/epidemiology/genetics  Child  Child, Preschool  Cohort Studies  Female  Humans  Male  Mothers  Neurodevelopmental Disorders/complications/epidemiology/genetics  Risk Factors  Adhd  MoBa  Polygenic risk score  autism  hyperactivity  inattention  language and motor difficulties  neurodevelopmental disorders  repetitive behavior  schizophrenia  social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important to increase our understanding of how the polygenic risk for neurodevelopmental disorders manifests during childhood in boys and girls. METHODS: Polygenic risk scores (PRS) for ADHD, autism and schizophrenia were calculated in a subsample of 15 205 children from the Norwegian Mother, Father and Child Cohort Study (MoBa). Mother-reported traits of repetitive behavior, social communication, language and motor difficulties, hyperactivity and inattention were measured in children at 6 and 18 months, 3, 5 and 8 years. Linear regression models in a multigroup framework were used to investigate associations between the three PRS and dimensional trait measures in MoBa, using sex as a grouping variable. RESULTS: Before the age of 2, the ADHD PRS was robustly associated with hyperactivity and inattention, with increasing strength up to 8 years, and with language difficulties at age 5 and 8. The autism PRS was robustly associated with language difficulties at 18 months, motor difficulties at 36 months, and hyperactivity and inattention at 8 years. We did not identify robust associations for the schizophrenia PRS. In general, the PRS associations were similar in boys and girls. The association between ADHD PRS and hyperactivity at 18 months was, however, stronger in boys. CONCLUSIONS: Polygenic risk for autism and ADHD in the general population manifests early in childhood and broadly across behavioral measures of neurodevelopmental traits. En ligne : http://dx.doi.org/10.1111/jcpp.13528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury / Ana G. CRISTANCHO in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury Type de document : texte imprimé Auteurs : Ana G. CRISTANCHO, Auteur ; Eric D. MARSH, Auteur Langues : Anglais (eng) Mots-clés : Brain  Child  DNA Methylation  Epigenesis, Genetic  Humans  Hypoxia  Infant, Newborn  Neurodevelopmental Disorders  Brain development  Epigenetics  Histone modification  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: The fetal brain is adapted to the hypoxic conditions present during normal in utero development. Relatively more hypoxic states, either chronic or acute, are pathologic and can lead to significant long-term neurodevelopmental sequelae. In utero hypoxic injury is associated with neonatal mortality and millions of lives lived with varying degrees of disability. MAIN BODY: Genetic studies of children with neurodevelopmental disease indicate that epigenetic modifiers regulating DNA methylation and histone remodeling are critical for normal brain development. Epigenetic modifiers are also regulated by environmental stimuli, such as hypoxia. Indeed, epigenetic modifiers that are mutated in children with genetic neurodevelopmental diseases are regulated by hypoxia in a number of preclinical models and may be part of the mechanism for the long-term neurodevelopmental sequelae seem in children with hypoxic brain injury. Thus, a comprehensive understanding the role of DNA methylation and histone modifications in hypoxic injury is critical for developing novel strategies to treat children with hypoxic injury. CONCLUSIONS: This review focuses on our current understanding of the intersection between epigenetics, brain development, and hypoxia. Opportunities for the use of epigenetics as biomarkers of neurodevelopmental disease after hypoxic injury and potential clinical epigenetics targets to improve outcomes after injury are also discussed. While there have been many published studies on the epigenetics of hypoxia, more are needed in the developing brain in order to determine which epigenetic pathways may be most important for mitigating the long-term consequences of hypoxic brain injury. En ligne : https://dx.doi.org/10.1186/s11689-020-09344-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury [texte imprimé] / Ana G. CRISTANCHO, Auteur ; Eric D. MARSH, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Brain  Child  DNA Methylation  Epigenesis, Genetic  Humans  Hypoxia  Infant, Newborn  Neurodevelopmental Disorders  Brain development  Epigenetics  Histone modification  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: The fetal brain is adapted to the hypoxic conditions present during normal in utero development. Relatively more hypoxic states, either chronic or acute, are pathologic and can lead to significant long-term neurodevelopmental sequelae. In utero hypoxic injury is associated with neonatal mortality and millions of lives lived with varying degrees of disability. MAIN BODY: Genetic studies of children with neurodevelopmental disease indicate that epigenetic modifiers regulating DNA methylation and histone remodeling are critical for normal brain development. Epigenetic modifiers are also regulated by environmental stimuli, such as hypoxia. Indeed, epigenetic modifiers that are mutated in children with genetic neurodevelopmental diseases are regulated by hypoxia in a number of preclinical models and may be part of the mechanism for the long-term neurodevelopmental sequelae seem in children with hypoxic brain injury. Thus, a comprehensive understanding the role of DNA methylation and histone modifications in hypoxic injury is critical for developing novel strategies to treat children with hypoxic injury. CONCLUSIONS: This review focuses on our current understanding of the intersection between epigenetics, brain development, and hypoxia. Opportunities for the use of epigenetics as biomarkers of neurodevelopmental disease after hypoxic injury and potential clinical epigenetics targets to improve outcomes after injury are also discussed. While there have been many published studies on the epigenetics of hypoxia, more are needed in the developing brain in order to determine which epigenetic pathways may be most important for mitigating the long-term consequences of hypoxic brain injury. En ligne : https://dx.doi.org/10.1186/s11689-020-09344-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Familial and genetic associations between autism spectrum disorder and other neurodevelopmental and psychiatric disorders / Laura GHIRARDI in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

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Genetic Testing in Patients with Neurodevelopmental Disorders: Experience of 511 Patients at Cincinnati Children's Hospital Medical Center / Xiaoli DU in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

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Longitudinal trajectories of mental health and loneliness for Australian adolescents with-or-without neurodevelopmental disorders: the impact of COVID-19 school lockdowns / Stephen HOUGHTON in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

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Reflections on the genetics-first approach to advancements in molecular genetic and neurobiological research on neurodevelopmental disorders / Anne B. ARNETT in Journal of Neurodevelopmental Disorders, 13 (2021)  

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Risk of neurodevelopmental disorders in children born from different ART treatments: a systematic review and meta-analysis / Tono DJUWANTONO in Journal of Neurodevelopmental Disorders, 12 (2020)  

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