[article]
| Titre : |
Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome |
| Type de document : |
texte imprimé |
| Auteurs : |
M. G. MARISCAL, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Joseph D. BUXBAUM, Auteur ; L. E. ETHRIDGE, Auteur ; R. FILIP-DHIMA, Auteur ; J. H. FOSS-FEIG, Auteur ; A. KOLEVZON, Auteur ; M. E. MODI, Auteur ; M. W. MOSCONI, Auteur ; C. A. NELSON, Auteur ; C. M. POWELL, Auteur ; P. M. SIPER, Auteur ; L. SOORYA, Auteur ; A. THALIATH, Auteur ; A. THURM, Auteur ; B. ZHANG, Auteur ; M. SAHIN, Auteur ; A. R. LEVIN, Auteur |
| Article en page(s) : |
29 p. |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Cross-frequency coupling Eeg Phase bias Phelan-McDermid syndrome Power |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS. METHODS: Here, we analyze EEG data collected across multiple sites in individuals with PMS (n = 26) and typically developing individuals (n = 15). We quantify oscillatory power, alpha-gamma phase-amplitude coupling strength, and phase bias, a measure of the phase of cross frequency coupling thought to reflect the balance of feedforward (bottom-up) and feedback (top-down) activity. RESULTS: We find individuals with PMS display increased alpha-gamma phase bias (U = 3.841, p < 0.0005), predominantly over posterior electrodes. Most individuals with PMS demonstrate positive overall phase bias while most typically developing individuals demonstrate negative overall phase bias. Among individuals with PMS, strength of alpha-gamma phase-amplitude coupling was associated with Sameness, Ritualistic, and Compulsive behaviors as measured by the Repetitive Behavior Scales-Revised (Beta = 0.545, p = 0.011). CONCLUSIONS: Increased phase bias suggests potential circuit-level mechanisms underlying phenotype in PMS, offering opportunities for back-translation of findings into animal models and targeting in clinical trials. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-020-00411-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 |
in Molecular Autism > 12 (2021) . - 29 p.
[article] Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome [texte imprimé] / M. G. MARISCAL, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Joseph D. BUXBAUM, Auteur ; L. E. ETHRIDGE, Auteur ; R. FILIP-DHIMA, Auteur ; J. H. FOSS-FEIG, Auteur ; A. KOLEVZON, Auteur ; M. E. MODI, Auteur ; M. W. MOSCONI, Auteur ; C. A. NELSON, Auteur ; C. M. POWELL, Auteur ; P. M. SIPER, Auteur ; L. SOORYA, Auteur ; A. THALIATH, Auteur ; A. THURM, Auteur ; B. ZHANG, Auteur ; M. SAHIN, Auteur ; A. R. LEVIN, Auteur . - 29 p. Langues : Anglais ( eng) in Molecular Autism > 12 (2021) . - 29 p.
| Mots-clés : |
Cross-frequency coupling Eeg Phase bias Phelan-McDermid syndrome Power |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS. METHODS: Here, we analyze EEG data collected across multiple sites in individuals with PMS (n = 26) and typically developing individuals (n = 15). We quantify oscillatory power, alpha-gamma phase-amplitude coupling strength, and phase bias, a measure of the phase of cross frequency coupling thought to reflect the balance of feedforward (bottom-up) and feedback (top-down) activity. RESULTS: We find individuals with PMS display increased alpha-gamma phase bias (U = 3.841, p < 0.0005), predominantly over posterior electrodes. Most individuals with PMS demonstrate positive overall phase bias while most typically developing individuals demonstrate negative overall phase bias. Among individuals with PMS, strength of alpha-gamma phase-amplitude coupling was associated with Sameness, Ritualistic, and Compulsive behaviors as measured by the Repetitive Behavior Scales-Revised (Beta = 0.545, p = 0.011). CONCLUSIONS: Increased phase bias suggests potential circuit-level mechanisms underlying phenotype in PMS, offering opportunities for back-translation of findings into animal models and targeting in clinical trials. |
| En ligne : |
http://dx.doi.org/10.1186/s13229-020-00411-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 |
|  |
Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome in Molecular Autism, 12 (2021)
