Is theory of mind related to social dysfunction and emotional problems in 22q11.2 deletion syndrome (velo-cardio-facial syndrome)? / Linda E. CAMPBELL in Journal of Neurodevelopmental Disorders, 3-2 (June 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-2 (June 2011) . - p.152-61 Titre : Is theory of mind related to social dysfunction and emotional problems in 22q11.2 deletion syndrome (velo-cardio-facial syndrome)? Type de document : Texte imprimé et/ou numérique Auteurs : Linda E. CAMPBELL, Auteur ; A. F. STEVENS, Auteur ; K. MCCABE, Auteur ; L. CRUICKSHANK, Auteur ; R. G. MORRIS, Auteur ; D. G. MURPHY, Auteur ; K. C. MURPHY, Auteur Article en page(s) : p.152-61 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Social dysfunction is intrinsically involved in severe psychiatric disorders such as depression and psychosis and linked with poor theory of mind. Children with 22q11.2 deletion syndrome (22q11DS, or velo-cardio-facial syndrome) have poor social competence and are also at a particularly high risk of developing mood (40%) and psychotic (up to 30%) disorders in adolescence and young adulthood. However, it is unknown if these problems are associated with theory of mind skills, including underlying social-cognitive and social-perceptual mechanisms. The present cross-sectional study included classic social-cognitive false-belief and mentalising tasks and social-perceptual face processing tasks. The performance of 50 children with 22q11DS was compared with 31 age-matched typically developing sibling controls. Key findings indicated that, while younger children with 22q11DS showed impaired acquisition of social-cognitive skills, older children with 22q11DS were not significantly impaired compared with sibling controls. However, children with 22q11DS were found to have social-perceptual deficits, as demonstrated by difficulties in matching faces on the basis of identity, emotion, facial speech and gaze compared with sibling controls. Furthermore, performance on the tasks was associated with age, language ability and parentally rated social competence and emotional problems. These results are discussed in relation to the importance of a better delineation of social competence in this population. En ligne : http://dx.doi.org/10.1007/s11689-011-9082-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343 [article] Is theory of mind related to social dysfunction and emotional problems in 22q11.2 deletion syndrome (velo-cardio-facial syndrome)? [Texte imprimé et/ou numérique] / Linda E. CAMPBELL, Auteur ; A. F. STEVENS, Auteur ; K. MCCABE, Auteur ; L. CRUICKSHANK, Auteur ; R. G. MORRIS, Auteur ; D. G. MURPHY, Auteur ; K. C. MURPHY, Auteur . - p.152-61. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-2 (June 2011) . - p.152-61 Index. décimale : PER Périodiques Résumé : Social dysfunction is intrinsically involved in severe psychiatric disorders such as depression and psychosis and linked with poor theory of mind. Children with 22q11.2 deletion syndrome (22q11DS, or velo-cardio-facial syndrome) have poor social competence and are also at a particularly high risk of developing mood (40%) and psychotic (up to 30%) disorders in adolescence and young adulthood. However, it is unknown if these problems are associated with theory of mind skills, including underlying social-cognitive and social-perceptual mechanisms. The present cross-sectional study included classic social-cognitive false-belief and mentalising tasks and social-perceptual face processing tasks. The performance of 50 children with 22q11DS was compared with 31 age-matched typically developing sibling controls. Key findings indicated that, while younger children with 22q11DS showed impaired acquisition of social-cognitive skills, older children with 22q11DS were not significantly impaired compared with sibling controls. However, children with 22q11DS were found to have social-perceptual deficits, as demonstrated by difficulties in matching faces on the basis of identity, emotion, facial speech and gaze compared with sibling controls. Furthermore, performance on the tasks was associated with age, language ability and parentally rated social competence and emotional problems. These results are discussed in relation to the importance of a better delineation of social competence in this population. En ligne : http://dx.doi.org/10.1007/s11689-011-9082-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343

Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study / R. AZUMA in Journal of Neurodevelopmental Disorders, 1-1 (March 2009)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.46-60 Titre : Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study Type de document : Texte imprimé et/ou numérique Auteurs : R. AZUMA, Auteur ; Eileen DALY, Auteur ; Linda E. CAMPBELL, Auteur ; A. F. STEVENS, Auteur ; Quinton DEELEY, Auteur ; V. GIAMPIETRO, Auteur ; Michael BRAMMER, Auteur ; B. GLASER, Auteur ; F. Z. AMBERY, Auteur ; R. G. MORRIS, Auteur ; S. C. WILLIAMS, Auteur ; M. J. OWEN, Auteur ; D. G. MURPHY, Auteur ; K. C. MURPHY, Auteur Article en page(s) : p.46-60 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an age-related decrease in anterior regions, the 22q11DS children showed the opposite pattern. Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-009-9008-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341 [article] Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study [Texte imprimé et/ou numérique] / R. AZUMA, Auteur ; Eileen DALY, Auteur ; Linda E. CAMPBELL, Auteur ; A. F. STEVENS, Auteur ; Quinton DEELEY, Auteur ; V. GIAMPIETRO, Auteur ; Michael BRAMMER, Auteur ; B. GLASER, Auteur ; F. Z. AMBERY, Auteur ; R. G. MORRIS, Auteur ; S. C. WILLIAMS, Auteur ; M. J. OWEN, Auteur ; D. G. MURPHY, Auteur ; K. C. MURPHY, Auteur . - p.46-60. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 1-1 (March 2009) . - p.46-60 Index. décimale : PER Périodiques Résumé : 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with a microdeletion of chromosome 22q11. In addition to high rates of neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder, children with 22q11DS have a specific neuropsychological profile with particular deficits in visuospatial and working memory. However, the neurobiological substrate underlying these deficits is poorly understood. We investigated brain function during a visuospatial working memory (SWM) task in eight children with 22q11DS and 13 healthy controls, using fMRI. Both groups showed task-related activation in dorsolateral prefrontal cortex (DLPFC) and bilateral parietal association cortices. Controls activated parietal and occipital regions significantly more than those with 22q11DS but there was no significant between-group difference in DLPFC. In addition, while controls had a significant age-related increase in the activation of posterior brain regions and an age-related decrease in anterior regions, the 22q11DS children showed the opposite pattern. Genetically determined differences in the development of specific brain systems may underpin the cognitive deficits in 22q11DS, and may contribute to the later development of neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1007/s11689-009-9008-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=341

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