Initially intact neural responses to pain in autism are diminished during sustained pain / M. D. FAILLA in Autism, 22-6 (August 2018)  

Public ISBD [article]  inAutism > 22-6 (August 2018) . - p.669-683 Titre : Initially intact neural responses to pain in autism are diminished during sustained pain Type de document : Texte imprimé et/ou numérique Auteurs : M. D. FAILLA, Auteur ; E. J. MOANA-FILHO, Auteur ; G. K. ESSICK, Auteur ; Grace T. BARANEK, Auteur ; B. P. ROGERS, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : p.669-683 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  functional magnetic resonance imaging  pain  repetitive behaviors  self-injury  sensory Index. décimale : PER Périodiques Résumé : Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reduction in autism spectrum disorder. Intact early responses, followed by diminished late responses to sustained pain, may reflect altered pain coping or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to initial versus protracted pain may clarify the coexistence of both hypo- and hyperresponsiveness to pain in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317696043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Initially intact neural responses to pain in autism are diminished during sustained pain [Texte imprimé et/ou numérique] / M. D. FAILLA, Auteur ; E. J. MOANA-FILHO, Auteur ; G. K. ESSICK, Auteur ; Grace T. BARANEK, Auteur ; B. P. ROGERS, Auteur ; Carissa J. CASCIO, Auteur . - p.669-683. Langues : Anglais (eng) in Autism > 22-6 (August 2018) . - p.669-683 Mots-clés : autism spectrum disorder  functional magnetic resonance imaging  pain  repetitive behaviors  self-injury  sensory Index. décimale : PER Périodiques Résumé : Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reduction in autism spectrum disorder. Intact early responses, followed by diminished late responses to sustained pain, may reflect altered pain coping or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to initial versus protracted pain may clarify the coexistence of both hypo- and hyperresponsiveness to pain in autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317696043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Response of neural reward regions to food cues in autism spectrum disorders / Carissa J. CASCIO in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.9 Titre : Response of neural reward regions to food cues in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Carissa J. CASCIO, Auteur ; J. H. FOSS-FEIG, Auteur ; J. L. HEACOCK, Auteur ; C. R. NEWSOM, Auteur ; R. L. COWAN, Auteur ; M. M. BENNINGFIELD, Auteur ; B. P. ROGERS, Auteur ; A. CAO, Auteur Article en page(s) : p.9 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: One hypothesis for the social deficits that characterize autism spectrum disorders (ASD) is diminished neural reward response to social interaction and attachment. Prior research using established monetary reward paradigms as a test of non-social reward to compare with social reward may involve confounds in the ability of individuals with ASD to utilize symbolic representation of money and the abstraction required to interpret monetary gains. Thus, a useful addition to our understanding of neural reward circuitry in ASD includes a characterization of the neural response to primary rewards. METHOD: We asked 17 children with ASD and 18 children without ASD to abstain from eating for at least four hours before an MRI scan in which they viewed images of high-calorie foods. We assessed the neural reward network for increases in the blood oxygenation level dependent (BOLD) signal in response to the food images RESULTS: We found very similar patterns of increased BOLD signal to these images in the two groups; both groups showed increased BOLD signal in the bilateral amygdala, as well as in the nucleus accumbens, orbitofrontal cortex, and insula. Direct group comparisons revealed that the ASD group showed a stronger response to food cues in bilateral insula along the anterior-posterior gradient and in the anterior cingulate cortex than the control group, whereas there were no neural reward regions that showed higher activation for controls than for ASD. CONCLUSION: These results suggest that neural response to primary rewards is not diminished but in fact shows an aberrant enhancement in children with ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Response of neural reward regions to food cues in autism spectrum disorders [Texte imprimé et/ou numérique] / Carissa J. CASCIO, Auteur ; J. H. FOSS-FEIG, Auteur ; J. L. HEACOCK, Auteur ; C. R. NEWSOM, Auteur ; R. L. COWAN, Auteur ; M. M. BENNINGFIELD, Auteur ; B. P. ROGERS, Auteur ; A. CAO, Auteur . - p.9. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.9 Index. décimale : PER Périodiques Résumé : BACKGROUND: One hypothesis for the social deficits that characterize autism spectrum disorders (ASD) is diminished neural reward response to social interaction and attachment. Prior research using established monetary reward paradigms as a test of non-social reward to compare with social reward may involve confounds in the ability of individuals with ASD to utilize symbolic representation of money and the abstraction required to interpret monetary gains. Thus, a useful addition to our understanding of neural reward circuitry in ASD includes a characterization of the neural response to primary rewards. METHOD: We asked 17 children with ASD and 18 children without ASD to abstain from eating for at least four hours before an MRI scan in which they viewed images of high-calorie foods. We assessed the neural reward network for increases in the blood oxygenation level dependent (BOLD) signal in response to the food images RESULTS: We found very similar patterns of increased BOLD signal to these images in the two groups; both groups showed increased BOLD signal in the bilateral amygdala, as well as in the nucleus accumbens, orbitofrontal cortex, and insula. Direct group comparisons revealed that the ASD group showed a stronger response to food cues in bilateral insula along the anterior-posterior gradient and in the anterior cingulate cortex than the control group, whereas there were no neural reward regions that showed higher activation for controls than for ASD. CONCLUSION: These results suggest that neural response to primary rewards is not diminished but in fact shows an aberrant enhancement in children with ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

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