[article]
| Titre : |
Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders |
| Type de document : |
texte imprimé |
| Auteurs : |
Jill ESCHER, Auteur ; Wei YAN, Auteur ; Emilie F. RISSMAN, Auteur ; Hsiao-Lin V. WANG, Auteur ; Arturo HERNANDEZ, Auteur ; Victor G. CORCES, Auteur |
| Article en page(s) : |
p.4608-4624 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorder Epigenetics Gene expression Genetic toxicology Germ cells Non-genetic inheritance |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Investigations into the etiology of autism spectrum disorders have been largely confined to two realms: variations in DNA sequence and somatic developmental exposures. Here we suggest a third route-disruption of the germline epigenome induced by exogenous toxicants during a parent's gamete development. Similar to cases of germline mutation, these molecular perturbations may produce dysregulated transcription of brain-related genes during fetal and early development, resulting in abnormal neurobehavioral phenotypes in offspring. Many types of exposures may have these impacts, and here we discuss examples of anesthetic gases, tobacco components, synthetic steroids, and valproic acid. Alterations in parental germline could help explain some unsolved phenomena of autism, including increased prevalence, missing heritability, skewed sex ratio, and heterogeneity of neurobiology and behavior. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-021-05304-1 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 |
in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4608-4624
[article] Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders [texte imprimé] / Jill ESCHER, Auteur ; Wei YAN, Auteur ; Emilie F. RISSMAN, Auteur ; Hsiao-Lin V. WANG, Auteur ; Arturo HERNANDEZ, Auteur ; Victor G. CORCES, Auteur . - p.4608-4624. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4608-4624
| Mots-clés : |
Autism spectrum disorder Epigenetics Gene expression Genetic toxicology Germ cells Non-genetic inheritance |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Investigations into the etiology of autism spectrum disorders have been largely confined to two realms: variations in DNA sequence and somatic developmental exposures. Here we suggest a third route-disruption of the germline epigenome induced by exogenous toxicants during a parent's gamete development. Similar to cases of germline mutation, these molecular perturbations may produce dysregulated transcription of brain-related genes during fetal and early development, resulting in abnormal neurobehavioral phenotypes in offspring. Many types of exposures may have these impacts, and here we discuss examples of anesthetic gases, tobacco components, synthetic steroids, and valproic acid. Alterations in parental germline could help explain some unsolved phenomena of autism, including increased prevalence, missing heritability, skewed sex ratio, and heterogeneity of neurobiology and behavior. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-021-05304-1 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 |
|  |
Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders in Journal of Autism and Developmental Disorders, 52-10 (October 2022)
