[article]
| Titre : |
Oxytocin Exposure in Labor and its Relationship with Cognitive Impairment and the Genetic Architecture of Autism |
| Type de document : |
texte imprimé |
| Auteurs : |
Alicia GARCIA-ALCON, Auteur ; Javier GONZALEZ-PENAS, Auteur ; Elisa WECKX, Auteur ; M. J. PENZOL, Auteur ; Xaquin GURRIARAN, Auteur ; Javier COSTAS, Auteur ; Covadonga M. DIAZ-CANEJA, Auteur ; Carmen MORENO, Auteur ; Patricia HERNANDEZ, Auteur ; Celso ARANGO, Auteur ; Mara PARELLADA, Auteur |
| Article en page(s) : |
p.66-79 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Whether there is a relationship between oxytocin (OXT) use in labor and the risk of autism (ASD), and the nature of such relationship, is unclear. By integrating genetic and clinical data in a sample of 176 ASD participants, we tested the hypothesis that OXT is a marker for abnormal prenatal development which leads to impairments in the process of labor. OXT-exposed ASD had more obstetric complications (P=0.031), earlier onset of symptoms (P=0.027), poorer cognitive development (P=0.011), higher mutation burden across neurodevelopment genes (P=0.020; OR=5.33) and lower transmission of polygenic risk for ASD (P=0.0319), than non-exposed ASD. OXT seems to constitute a risk indicator rather than a risk factor for ASD, which is relevant for diagnostic and genetic counselling. |
| En ligne : |
https://doi.org/10.1007/s10803-021-05409-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 |
in Journal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.66-79
[article] Oxytocin Exposure in Labor and its Relationship with Cognitive Impairment and the Genetic Architecture of Autism [texte imprimé] / Alicia GARCIA-ALCON, Auteur ; Javier GONZALEZ-PENAS, Auteur ; Elisa WECKX, Auteur ; M. J. PENZOL, Auteur ; Xaquin GURRIARAN, Auteur ; Javier COSTAS, Auteur ; Covadonga M. DIAZ-CANEJA, Auteur ; Carmen MORENO, Auteur ; Patricia HERNANDEZ, Auteur ; Celso ARANGO, Auteur ; Mara PARELLADA, Auteur . - p.66-79. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.66-79
| Index. décimale : |
PER Périodiques |
| Résumé : |
Whether there is a relationship between oxytocin (OXT) use in labor and the risk of autism (ASD), and the nature of such relationship, is unclear. By integrating genetic and clinical data in a sample of 176 ASD participants, we tested the hypothesis that OXT is a marker for abnormal prenatal development which leads to impairments in the process of labor. OXT-exposed ASD had more obstetric complications (P=0.031), earlier onset of symptoms (P=0.027), poorer cognitive development (P=0.011), higher mutation burden across neurodevelopment genes (P=0.020; OR=5.33) and lower transmission of polygenic risk for ASD (P=0.0319), than non-exposed ASD. OXT seems to constitute a risk indicator rather than a risk factor for ASD, which is relevant for diagnostic and genetic counselling. |
| En ligne : |
https://doi.org/10.1007/s10803-021-05409-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 |
|  |
Oxytocin Exposure in Labor and its Relationship with Cognitive Impairment and the Genetic Architecture of Autism in Journal of Autism and Developmental Disorders, 53-1 (January 2023)
