Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187 Titre : Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur Année de publication : 2010 Article en page(s) : p.180-187 Langues : Anglais (eng) Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20. Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S. Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant. Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 [article] Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur . - 2010 . - p.180-187. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187 Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20. Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S. Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant. Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941

Early-life adversity and risk for depression and anxiety: The role of interpersonal support / Allison V. METTS in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.863-875 Titre : Early-life adversity and risk for depression and anxiety: The role of interpersonal support Type de document : Texte imprimé et/ou numérique Auteurs : Allison V. METTS, Auteur ; Julia S. YARRINGTON, Auteur ; Richard ZINBARG, Auteur ; Constance HAMMEN, Auteur ; Susan MINEKA, Auteur ; Craig ENDERS, Auteur ; Michelle G. CRASKE, Auteur Article en page(s) : p.863-875 Langues : Anglais (eng) Mots-clés : anxiety  depression  early-life adversity  general benefits  interpersonal support Index. décimale : PER Périodiques Résumé : Early-life adversity is a major risk factor for psychopathology, but not all who experience adversity develop psychopathology. The current study evaluated whether the links between child and adolescent adversity and depression and anxiety were described by general benefits and/or buffering effects of interpersonal support. Data from 456 adolescents oversampled on neuroticism over a 5-year period were examined in a series of discrete-time survival analyses to predict subsequent disorder onsets. Models examined linear, quadratic, and interactive effects of interpersonal support over time, as measured by chronic interpersonal stress interview ratings. Results did not support buffering effects of interpersonal support against either child or adolescent adversity in predicting depression or anxiety. However, there was support for the general benefits model of interpersonal support as evidenced by follow-up analyses of significant quadratic effects of interpersonal support, demonstrating that higher interpersonal support led to decreased likelihood of depression and anxiety onsets. Secondary analyses demonstrated that effects of interpersonal support remained after accounting for baseline depression and anxiety diagnoses. Further, quadratic effects were driven by social domains as opposed to familial domains when considering child adversity. Implications for interventions and randomized controlled prevention trials regarding interpersonal relationships are discussed. En ligne : http://dx.doi.org/10.1017/S0954579422000116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Early-life adversity and risk for depression and anxiety: The role of interpersonal support [Texte imprimé et/ou numérique] / Allison V. METTS, Auteur ; Julia S. YARRINGTON, Auteur ; Richard ZINBARG, Auteur ; Constance HAMMEN, Auteur ; Susan MINEKA, Auteur ; Craig ENDERS, Auteur ; Michelle G. CRASKE, Auteur . - p.863-875. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.863-875 Mots-clés : anxiety  depression  early-life adversity  general benefits  interpersonal support Index. décimale : PER Périodiques Résumé : Early-life adversity is a major risk factor for psychopathology, but not all who experience adversity develop psychopathology. The current study evaluated whether the links between child and adolescent adversity and depression and anxiety were described by general benefits and/or buffering effects of interpersonal support. Data from 456 adolescents oversampled on neuroticism over a 5-year period were examined in a series of discrete-time survival analyses to predict subsequent disorder onsets. Models examined linear, quadratic, and interactive effects of interpersonal support over time, as measured by chronic interpersonal stress interview ratings. Results did not support buffering effects of interpersonal support against either child or adolescent adversity in predicting depression or anxiety. However, there was support for the general benefits model of interpersonal support as evidenced by follow-up analyses of significant quadratic effects of interpersonal support, demonstrating that higher interpersonal support led to decreased likelihood of depression and anxiety onsets. Secondary analyses demonstrated that effects of interpersonal support remained after accounting for baseline depression and anxiety diagnoses. Further, quadratic effects were driven by social domains as opposed to familial domains when considering child adversity. Implications for interventions and randomized controlled prevention trials regarding interpersonal relationships are discussed. En ligne : http://dx.doi.org/10.1017/S0954579422000116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 49-4 (April 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440 Titre : Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur Année de publication : 2008 Article en page(s) : p.433–440 Langues : Anglais (eng) Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed. Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles. Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20. Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur . - 2008 . - p.433–440. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440 Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed. Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles. Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20. Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

Genetic moderation of the association between adolescent romantic involvement and depression: Contributions of serotonin transporter gene polymorphism, chronic stress, and family discord / Lisa R. STARR in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.447-457 Titre : Genetic moderation of the association between adolescent romantic involvement and depression: Contributions of serotonin transporter gene polymorphism, chronic stress, and family discord Type de document : Texte imprimé et/ou numérique Auteurs : Lisa R. STARR, Auteur ; Constance HAMMEN, Auteur Article en page(s) : p.447-457 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies support a link between adolescent romantic involvement and depression. Adolescent romantic relationships may increase depression risk by introducing chronic stress, and genetic vulnerability to stress reactivity/emotion dysregulation may moderate these associations. We tested genetic moderation of longitudinal associations between adolescent romantic involvement and later depressive symptoms by a polymorphism in the serotonin transporter linked polymorphic region gene (5-HTTLPR) and examined contributory roles of chronic stress and family discord. Three hundred eighty-one youth participated at ages 15 and 20. The results indicated that 5-HTTLPR moderated the association between age 15 romantic involvement and age 20 depressive symptoms, with strongest effects for short homozygotes. Conditional process analysis revealed that chronic stress functioned as a moderated mediator of this association, fully accounting for the romantic involvement–depression link among short/short genotypes. Also, romantic involvement predicted later depressive symptoms most strongly among short-allele carriers with high family discord. The results have important implications for understanding the romantic involvement–depression link and the behavioral and emotional correlates of the 5-HTTLPR genotype. En ligne : http://dx.doi.org/10.1017/S0954579415000498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Genetic moderation of the association between adolescent romantic involvement and depression: Contributions of serotonin transporter gene polymorphism, chronic stress, and family discord [Texte imprimé et/ou numérique] / Lisa R. STARR, Auteur ; Constance HAMMEN, Auteur . - p.447-457. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.447-457 Index. décimale : PER Périodiques Résumé : Studies support a link between adolescent romantic involvement and depression. Adolescent romantic relationships may increase depression risk by introducing chronic stress, and genetic vulnerability to stress reactivity/emotion dysregulation may moderate these associations. We tested genetic moderation of longitudinal associations between adolescent romantic involvement and later depressive symptoms by a polymorphism in the serotonin transporter linked polymorphic region gene (5-HTTLPR) and examined contributory roles of chronic stress and family discord. Three hundred eighty-one youth participated at ages 15 and 20. The results indicated that 5-HTTLPR moderated the association between age 15 romantic involvement and age 20 depressive symptoms, with strongest effects for short homozygotes. Conditional process analysis revealed that chronic stress functioned as a moderated mediator of this association, fully accounting for the romantic involvement–depression link among short/short genotypes. Also, romantic involvement predicted later depressive symptoms most strongly among short-allele carriers with high family discord. The results have important implications for understanding the romantic involvement–depression link and the behavioral and emotional correlates of the 5-HTTLPR genotype. En ligne : http://dx.doi.org/10.1017/S0954579415000498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood / Brooke G. MCKENNA in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.122-134 Titre : HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.122-134 Langues : Anglais (eng) Mots-clés : HPA Axis  depression  fetal programming  polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood [Texte imprimé et/ou numérique] / Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur . - p.122-134. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.122-134 Mots-clés : HPA Axis  depression  fetal programming  polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study / Lisa R. STARR in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

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