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HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood / Brooke G. MCKENNA in Development and Psychopathology, 33-1 (February 2021)
[article]
Titre : HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.122-134 Langues : Anglais (eng) Mots-clés : HPA Axis depression fetal programming polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Development and Psychopathology > 33-1 (February 2021) . - p.122-134[article] HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood [Texte imprimé et/ou numérique] / Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur . - p.122-134.
Langues : Anglais (eng)
in Development and Psychopathology > 33-1 (February 2021) . - p.122-134
Mots-clés : HPA Axis depression fetal programming polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 Prenatal maternal stress programs infant stress regulation / Elysia POGGI DAVIS in Journal of Child Psychology and Psychiatry, 52-2 (February 2011)
[article]
Titre : Prenatal maternal stress programs infant stress regulation Type de document : Texte imprimé et/ou numérique Auteurs : Elysia POGGI DAVIS, Auteur ; Laura M. GLYNN, Auteur ; Feizal WAFFARN, Auteur ; Curt A. SANDMAN, Auteur Année de publication : 2011 Article en page(s) : p.119-129 Langues : Anglais (eng) Mots-clés : Pregnancy stress cortisol development glucocorticoids prenatal anxiety depression infancy fetal programming Index. décimale : PER Périodiques Résumé : Objective: Prenatal exposure to inappropriate levels of glucocorticoids (GCs) and maternal stress are putative mechanisms for the fetal programming of later health outcomes. The current investigation examined the influence of prenatal maternal cortisol and maternal psychosocial stress on infant physiological and behavioral responses to stress.
Methods: The study sample comprised 116 women and their full term infants. Maternal plasma cortisol and report of stress, anxiety and depression were assessed at 15, 19, 25, 31 and 36 + weeks’ gestational age. Infant cortisol and behavioral responses to the painful stress of a heel-stick blood draw were evaluated at 24 hours after birth. The association between prenatal maternal measures and infant cortisol and behavioral stress responses was examined using hierarchical linear growth curve modeling.
Results: A larger infant cortisol response to the heel-stick procedure was associated with exposure to elevated concentrations of maternal cortisol during the late second and third trimesters. Additionally, a slower rate of behavioral recovery from the painful stress of a heel-stick blood draw was predicted by elevated levels of maternal cortisol early in pregnancy as well as prenatal maternal psychosocial stress throughout gestation. These associations could not be explained by mode of delivery, prenatal medical history, socioeconomic status or child race, sex or birth order.
Conclusions: These data suggest that exposure to maternal cortisol and psychosocial stress exerts programming influences on the developing fetus with consequences for infant stress regulation.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02314.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.119-129[article] Prenatal maternal stress programs infant stress regulation [Texte imprimé et/ou numérique] / Elysia POGGI DAVIS, Auteur ; Laura M. GLYNN, Auteur ; Feizal WAFFARN, Auteur ; Curt A. SANDMAN, Auteur . - 2011 . - p.119-129.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.119-129
Mots-clés : Pregnancy stress cortisol development glucocorticoids prenatal anxiety depression infancy fetal programming Index. décimale : PER Périodiques Résumé : Objective: Prenatal exposure to inappropriate levels of glucocorticoids (GCs) and maternal stress are putative mechanisms for the fetal programming of later health outcomes. The current investigation examined the influence of prenatal maternal cortisol and maternal psychosocial stress on infant physiological and behavioral responses to stress.
Methods: The study sample comprised 116 women and their full term infants. Maternal plasma cortisol and report of stress, anxiety and depression were assessed at 15, 19, 25, 31 and 36 + weeks’ gestational age. Infant cortisol and behavioral responses to the painful stress of a heel-stick blood draw were evaluated at 24 hours after birth. The association between prenatal maternal measures and infant cortisol and behavioral stress responses was examined using hierarchical linear growth curve modeling.
Results: A larger infant cortisol response to the heel-stick procedure was associated with exposure to elevated concentrations of maternal cortisol during the late second and third trimesters. Additionally, a slower rate of behavioral recovery from the painful stress of a heel-stick blood draw was predicted by elevated levels of maternal cortisol early in pregnancy as well as prenatal maternal psychosocial stress throughout gestation. These associations could not be explained by mode of delivery, prenatal medical history, socioeconomic status or child race, sex or birth order.
Conclusions: These data suggest that exposure to maternal cortisol and psychosocial stress exerts programming influences on the developing fetus with consequences for infant stress regulation.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02314.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development / Leah A. GRANDE in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development Type de document : Texte imprimé et/ou numérique Auteurs : Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur Article en page(s) : p.1376-1385 Langues : Anglais (eng) Mots-clés : Child Development Child, Preschool Depression/psychology Female Humans Mothers/psychology Pregnancy Prenatal Exposure Delayed Effects/psychology Psychological Distress Stress, Psychological/psychology cognitive function depression fetal programming maternal care parenting prenatal stress resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Development and Psychopathology > 34-4 (October 2022) . - p.1376-1385[article] Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development [Texte imprimé et/ou numérique] / Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur . - p.1376-1385.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1376-1385
Mots-clés : Child Development Child, Preschool Depression/psychology Female Humans Mothers/psychology Pregnancy Prenatal Exposure Delayed Effects/psychology Psychological Distress Stress, Psychological/psychology cognitive function depression fetal programming maternal care parenting prenatal stress resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488