[article] inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454
| Titre : |
Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur |
| Année de publication : |
1979 |
| Article en page(s) : |
p.448-454 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 |
[article] Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique [Texte imprimé et/ou numérique] / W. I. FORSYTHE, Auteur ; M. P. PRENDERGAST, Auteur ; C. TOOTHILL, Auteur ; P. M. G. BROUGHTON, Auteur . - 1979 . - p.448-454. Langues : Anglais ( eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.448-454
| Index. décimale : |
PER Périodiques |
| Résumé : |
The enzyme multiple immuno-assay technique (EMIT) was used to study phenytoin serum levels in 50 children with seizures. It was found that: (1) a single dose of phenytoin suspension or capsules (5mg/kg/day) produced inadequate serum levels 16 and 24 hours after ingestion, and for this reason single dosage is not recommended; (2) twice-daily dosage of phenytoin suspension or capsules (5mg/kg/day) produced adequate serum levels in most children throughout the 24 hours, and this dosage is recommended; (3) 12 children continued to have seizures but when the dose was increased to 10mg/kg/day six of the 12 obtained control of seizures; (4) phenytoin reached equilibrium in the serum in five days provided the child had not previously been taking phenobarbitone; (5) of 13 children who had been taking phenobarbitone, 10 did not achieve equilibrium of phenytoin in serum for one to four weeks; (6) phenytoin suspension given twice-daily produced satisfactory serum levels provided the bottle was shaken well before dispensing; (7) apart from minor variations, phenytoin maintained its level in serum during the 14 to 30 months follow-up period, whether 5mg or 10mg/kg/day of phenytoin was given. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 |
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Phenytoin serum levels in children with epilepsy: a micro immuno-assay technique in Developmental Medicine & Child Neurology, 21-4 (August 1979)