Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course / Ilia N. KARATOREOS in Journal of Child Psychology and Psychiatry, 54-4 (April 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-4 (April 2013) . - p.337-347 Titre : Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course Type de document : Texte imprimé et/ou numérique Auteurs : Ilia N. KARATOREOS, Auteur ; Bruce S. MCEWEN, Auteur Article en page(s) : p.337-347 Mots-clés : Allostasis  hormones  neurobiology  aging  brain development Index. décimale : PER Périodiques Résumé : Background Adaptation is key to survival. An organism must adapt to environmental challenges in order to be able to thrive in the environment in which they find themselves. Resilience can be thought of as a measure of the ability of an organism to adapt, and to withstand challenges to its stability. In higher animals, the brain is a key player in this process of adaptation and resilience, and through a process known as “allostasis” can obtain “stability through change”; protecting homeostasis in the face of stressors in the environment. Mediators of allostasis, such as glucocorticoids, can cause changes in the structure and function of neural circuits, clearly impacting behavior. How developmental stage interacts with stress and leads to long-lasting changes is a key question addressed in this review. Scope and Methods We discuss the concept of allostasis, its role in resilience, the neural and physiological systems mediating these responses, the modulatory role of development, and the consequences for adult functioning. We present this in the context of mediators the brain and body engage to protect against threats to homeostasis. The review has been informed by comprehensive searches on PubMed and Scopus through November 2012. Findings Stressors in the environment can have long lasting effects on development, depending upon the stage of life at which they are experienced. As such, adverse childhood experiences can alter resilience of individuals, making it more difficult for them to respond normally to adverse situations in adulthood, but the brain maintains the capacity to re-enter a more plastic state where such effects can be mitigated. Conclusions The brain regulates responses that allow for adaptation to challenges in the environment. The capacity of the brain and body to withstand challenges to stability can be considered as “resilience”. While adverse childhood experiences can have long-term negative consequences, under the right circumstances, the brain can re-enter plastic states, and negative outcomes may be mitigated, even later in life. En ligne : http://dx.doi.org/10.1111/jcpp.12054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Annual Research Review: The neurobiology and physiology of resilience and adaptation across the life course [Texte imprimé et/ou numérique] / Ilia N. KARATOREOS, Auteur ; Bruce S. MCEWEN, Auteur . - p.337-347. in Journal of Child Psychology and Psychiatry > 54-4 (April 2013) . - p.337-347 Mots-clés : Allostasis  hormones  neurobiology  aging  brain development Index. décimale : PER Périodiques Résumé : Background Adaptation is key to survival. An organism must adapt to environmental challenges in order to be able to thrive in the environment in which they find themselves. Resilience can be thought of as a measure of the ability of an organism to adapt, and to withstand challenges to its stability. In higher animals, the brain is a key player in this process of adaptation and resilience, and through a process known as “allostasis” can obtain “stability through change”; protecting homeostasis in the face of stressors in the environment. Mediators of allostasis, such as glucocorticoids, can cause changes in the structure and function of neural circuits, clearly impacting behavior. How developmental stage interacts with stress and leads to long-lasting changes is a key question addressed in this review. Scope and Methods We discuss the concept of allostasis, its role in resilience, the neural and physiological systems mediating these responses, the modulatory role of development, and the consequences for adult functioning. We present this in the context of mediators the brain and body engage to protect against threats to homeostasis. The review has been informed by comprehensive searches on PubMed and Scopus through November 2012. Findings Stressors in the environment can have long lasting effects on development, depending upon the stage of life at which they are experienced. As such, adverse childhood experiences can alter resilience of individuals, making it more difficult for them to respond normally to adverse situations in adulthood, but the brain maintains the capacity to re-enter a more plastic state where such effects can be mitigated. Conclusions The brain regulates responses that allow for adaptation to challenges in the environment. The capacity of the brain and body to withstand challenges to stability can be considered as “resilience”. While adverse childhood experiences can have long-term negative consequences, under the right circumstances, the brain can re-enter plastic states, and negative outcomes may be mitigated, even later in life. En ligne : http://dx.doi.org/10.1111/jcpp.12054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

The Brain as a Target for Steroid Hormone Action / Bruce S. MCEWEN in Annual Review of Neuroscience, 2 (1979)

Public ISBD [article]  inAnnual Review of Neuroscience > 2 (1979) . - p.65-112 Titre : The Brain as a Target for Steroid Hormone Action Type de document : Texte imprimé et/ou numérique Auteurs : Bruce S. MCEWEN, Auteur ; Paula G. DAVIS, Auteur ; Bruce PARSONS, Auteur ; Donald W. PFAFF, Auteur Année de publication : 1979 Article en page(s) : p.65-112 Langues : Anglais (eng) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] The Brain as a Target for Steroid Hormone Action [Texte imprimé et/ou numérique] / Bruce S. MCEWEN, Auteur ; Paula G. DAVIS, Auteur ; Bruce PARSONS, Auteur ; Donald W. PFAFF, Auteur . - 1979 . - p.65-112. Langues : Anglais (eng) in Annual Review of Neuroscience > 2 (1979) . - p.65-112 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development / Robert-Paul JUSTER in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.725-776 Titre : A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development Type de document : Texte imprimé et/ou numérique Auteurs : Robert-Paul JUSTER, Auteur ; Gustav BIZIK, Auteur ; Martin PICARD, Auteur ; Genevieve ARSENAULT-LAPIERRE, Auteur ; Shireen SINDI, Auteur ; Lyane TREPANIER, Auteur ; Marie-France MARIN, Auteur ; Nathalie WAN, Auteur ; Zoran SEKEROVIC, Auteur ; Catherine LORD, Auteur ; Alexandra J. FIOCCO, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Bruce S. MCEWEN, Auteur ; Sonia J. LUPIEN, Auteur Année de publication : 2011 Article en page(s) : p.725-776 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress–disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health. En ligne : http://dx.doi.org/10.1017/S0954579411000289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development [Texte imprimé et/ou numérique] / Robert-Paul JUSTER, Auteur ; Gustav BIZIK, Auteur ; Martin PICARD, Auteur ; Genevieve ARSENAULT-LAPIERRE, Auteur ; Shireen SINDI, Auteur ; Lyane TREPANIER, Auteur ; Marie-France MARIN, Auteur ; Nathalie WAN, Auteur ; Zoran SEKEROVIC, Auteur ; Catherine LORD, Auteur ; Alexandra J. FIOCCO, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Bruce S. MCEWEN, Auteur ; Sonia J. LUPIEN, Auteur . - 2011 . - p.725-776. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.725-776 Index. décimale : PER Périodiques Résumé : The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress–disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health. En ligne : http://dx.doi.org/10.1017/S0954579411000289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

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