[article] 
inJournal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3648-3658

Titre :	Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Livia Nascimento RABELO, Auteur ; José Pablo Gonçalves QUEIROZ, Auteur ; Carla Cristina Miranda CASTRO, Auteur ; Sayonara Pereira SILVA, Auteur ; Laura Damasceno CAMPOS, Auteur ; Larissa Camila SILVA, Auteur ; Ezequiel Batista NASCIMENTO, Auteur ; Verónica MARTÍNEZ-CERDEÑO, Auteur ; Felipe Porto FIUZA, Auteur
Article en page(s) :	p.3648-3658
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	Autism spectrum disorder (ASD) is manifested by abnormal cell numbers and patches of gene expression disruption in higher-order brain regions. Here, we investigated whether layer-specific changes in glia/neuron ratios (GNR) characterize patches in the dorsolateral prefrontal cortex (DL-PFC) of children with ASD. We analyzed high-resolution digital images of postmortem human brains from 11 ASD and 11 non-ASD children obtained from the Autism Study of the Allen Human Brain Atlas. We found the GNR is overall reduced in the ASD DL-PFC. Moreover, layers II-III belonging to patches presented a lower GNR in comparison with layers V-VI. We here provide a new insight into how brain cells are arranged within patches that contributes to elucidate how neurodevelopmental programs are altered in ASD.
En ligne :	https://doi.org/10.1007/s10803-022-05626-8
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

[article] Layer-Specific Changes in the Prefrontal Glia/Neuron Ratio Characterizes Patches of Gene Expression Disorganization in Children with Autism [Texte imprimé et/ou numérique] / Livia Nascimento RABELO, Auteur ; José Pablo Gonçalves QUEIROZ, Auteur ; Carla Cristina Miranda CASTRO, Auteur ; Sayonara Pereira SILVA, Auteur ; Laura Damasceno CAMPOS, Auteur ; Larissa Camila SILVA, Auteur ; Ezequiel Batista NASCIMENTO, Auteur ; Verónica MARTÍNEZ-CERDEÑO, Auteur ; Felipe Porto FIUZA, Auteur . - p.3648-3658.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3648-3658

Index. décimale :	PER Périodiques
Résumé :	Autism spectrum disorder (ASD) is manifested by abnormal cell numbers and patches of gene expression disruption in higher-order brain regions. Here, we investigated whether layer-specific changes in glia/neuron ratios (GNR) characterize patches in the dorsolateral prefrontal cortex (DL-PFC) of children with ASD. We analyzed high-resolution digital images of postmortem human brains from 11 ASD and 11 non-ASD children obtained from the Autism Study of the Allen Human Brain Atlas. We found the GNR is overall reduced in the ASD DL-PFC. Moreover, layers II-III belonging to patches presented a lower GNR in comparison with layers V-VI. We here provide a new insight into how brain cells are arranged within patches that contributes to elucidate how neurodevelopmental programs are altered in ASD.
En ligne :	https://doi.org/10.1007/s10803-022-05626-8
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511