[article] 
inJournal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.894-904

Titre :	Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Dorinde M. VAN ANDEL, Auteur ; Jan J. SPRENGERS, Auteur ; Marsh KÖNIGS, Auteur ; Maretha V. DE JONGE, Auteur ; Hilgo BRUINING, Auteur
Article en page(s) :	p.894-904
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism Medication and Biomarker' (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment (??1 mg twice-daily) in unmedicated children 7-15 years with ASD. Children with IQ???70 were analyzed for baseline deficits and treatment-effects on the intention-to-treat-population with generalized-linear-models, principal component analysis and network analysis. Ninety-two children were allocated to treatment and 83 eligible for analyses. Heterogeneous neurocognitive impairments were found that were unaffected by bumetanide treatment. Network analysis showed higher modularity after treatment (mean difference:-0.165, 95%CI:-0.317 to ??0.013,p = .034) and changes in the relative importance of response inhibition in the neurocognitive network (mean difference:-0.037, 95%CI:-0.073 to ??0.001,p = .042). This study offers perspectives to include neurocognitive tests in ASD trials.
En ligne :	https://doi.org/10.1007/s10803-022-05841-3
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

[article] Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial [Texte imprimé et/ou numérique] / Dorinde M. VAN ANDEL, Auteur ; Jan J. SPRENGERS, Auteur ; Marsh KÖNIGS, Auteur ; Maretha V. DE JONGE, Auteur ; Hilgo BRUINING, Auteur . - p.894-904.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.894-904

Index. décimale :	PER Périodiques
Résumé :	We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism Medication and Biomarker' (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment (??1 mg twice-daily) in unmedicated children 7-15 years with ASD. Children with IQ???70 were analyzed for baseline deficits and treatment-effects on the intention-to-treat-population with generalized-linear-models, principal component analysis and network analysis. Ninety-two children were allocated to treatment and 83 eligible for analyses. Heterogeneous neurocognitive impairments were found that were unaffected by bumetanide treatment. Network analysis showed higher modularity after treatment (mean difference:-0.165, 95%CI:-0.317 to ??0.013,p = .034) and changes in the relative importance of response inhibition in the neurocognitive network (mean difference:-0.037, 95%CI:-0.073 to ??0.001,p = .042). This study offers perspectives to include neurocognitive tests in ASD trials.
En ligne :	https://doi.org/10.1007/s10803-022-05841-3
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524