[article]
Titre : |
Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Wen-Xiong CHEN, Auteur ; Yi-Ru CHEN, Auteur ; Min-Zhi PENG, Auteur ; Xian LIU, Auteur ; Yan-Na CAI, Auteur ; Zhi-Fang HUANG, Auteur ; Si-Yuan YANG, Auteur ; Jing-Yu HUANG, Auteur ; Ruo-Han WANG, Auteur ; Peng YI, Auteur ; Li LIU, Auteur |
Article en page(s) : |
p.1567-1581 |
Langues : |
Anglais (eng) |
Index. décimale : |
PER Périodiques |
Résumé : |
To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression. Compared with the control group, autistic children had significantly elevated glutamate, ?-Amino-n-butyric acid, glutamine, sarcosine, ?-aminolevulinic acid, glycine and citrulline. In contrast, their plasma level of ethanolamine, phenylalanine, tryptophan, homocysteine, pyroglutamic acid, hydroxyproline, ornithine, histidine, lysine, and glutathione were significantly lower. Elevated neuroactive amino acids (glutamate) and decreased essential amino acids were mostly distinct characteristics of PAAs of autistic children. Increased level of tryptophan might be associated with severity of autism. |
En ligne : |
https://doi.org/10.1007/s10803-022-05829-z |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 |
in Journal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1567-1581
[article] Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases [Texte imprimé et/ou numérique] / Wen-Xiong CHEN, Auteur ; Yi-Ru CHEN, Auteur ; Min-Zhi PENG, Auteur ; Xian LIU, Auteur ; Yan-Na CAI, Auteur ; Zhi-Fang HUANG, Auteur ; Si-Yuan YANG, Auteur ; Jing-Yu HUANG, Auteur ; Ruo-Han WANG, Auteur ; Peng YI, Auteur ; Li LIU, Auteur . - p.1567-1581. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 54-4 (April 2024) . - p.1567-1581
Index. décimale : |
PER Périodiques |
Résumé : |
To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression. Compared with the control group, autistic children had significantly elevated glutamate, ?-Amino-n-butyric acid, glutamine, sarcosine, ?-aminolevulinic acid, glycine and citrulline. In contrast, their plasma level of ethanolamine, phenylalanine, tryptophan, homocysteine, pyroglutamic acid, hydroxyproline, ornithine, histidine, lysine, and glutathione were significantly lower. Elevated neuroactive amino acids (glutamate) and decreased essential amino acids were mostly distinct characteristics of PAAs of autistic children. Increased level of tryptophan might be associated with severity of autism. |
En ligne : |
https://doi.org/10.1007/s10803-022-05829-z |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 |
|