[article] 
inDevelopment and Psychopathology > 20-3 (Summer 2008) . - p.745-774

Titre :	Ten good reasons to consider biological processes in prevention and intervention research
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Theodore P. BEAUCHAINE, Auteur ; Sharon L. BRENNER, Auteur ; Emily NEUHAUS, Auteur ; Lisa GATZKE-KOPP, Auteur
Année de publication :	2008
Article en page(s) :	p.745-774
Langues :	Anglais (eng)
Index. décimale :	PER Périodiques
Résumé :	Most contemporary accounts of psychopathology acknowledge the importance of both biological and environmental influences on behavior. In developmental psychopathology, multiple etiological mechanisms for psychiatric disturbance are well recognized, including those operating at genetic, neurobiological, and environmental levels of analysis. However, neuroscientific principles are rarely considered in current approaches to prevention or intervention. In this article, we explain why a deeper understanding of the genetic and neural substrates of behavior is essential for the next generation of preventive interventions, and we outline 10 specific reasons why considering biological processes can improve treatment efficacy. Among these, we discuss (a) the role of biomarkers and endophenotypes in identifying those most in need of prevention; (b) implications for treatment of genetic and neural mechanisms of homotypic comorbidity, heterotypic comorbidity, and heterotypic continuity; (c) ways in which biological vulnerabilities moderate the effects of environmental experience; (d) situations in which Biology × Environment interactions account for more variance in key outcomes than main effects; and (e) sensitivity of neural systems, via epigenesis, programming, and neural plasticity, to environmental moderation across the life span. For each of the 10 reasons outlined we present an example from current literature and discuss critical implications for prevention.
En ligne :	http://dx.doi.org/10.1017/s0954579408000369
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543

[article] Ten good reasons to consider biological processes in prevention and intervention research [Texte imprimé et/ou numérique] / Theodore P. BEAUCHAINE, Auteur ; Sharon L. BRENNER, Auteur ; Emily NEUHAUS, Auteur ; Lisa GATZKE-KOPP, Auteur . - 2008 . - p.745-774.
Langues : Anglais (eng)
in Development and Psychopathology > 20-3 (Summer 2008) . - p.745-774

Index. décimale :	PER Périodiques
Résumé :	Most contemporary accounts of psychopathology acknowledge the importance of both biological and environmental influences on behavior. In developmental psychopathology, multiple etiological mechanisms for psychiatric disturbance are well recognized, including those operating at genetic, neurobiological, and environmental levels of analysis. However, neuroscientific principles are rarely considered in current approaches to prevention or intervention. In this article, we explain why a deeper understanding of the genetic and neural substrates of behavior is essential for the next generation of preventive interventions, and we outline 10 specific reasons why considering biological processes can improve treatment efficacy. Among these, we discuss (a) the role of biomarkers and endophenotypes in identifying those most in need of prevention; (b) implications for treatment of genetic and neural mechanisms of homotypic comorbidity, heterotypic comorbidity, and heterotypic continuity; (c) ways in which biological vulnerabilities moderate the effects of environmental experience; (d) situations in which Biology × Environment interactions account for more variance in key outcomes than main effects; and (e) sensitivity of neural systems, via epigenesis, programming, and neural plasticity, to environmental moderation across the life span. For each of the 10 reasons outlined we present an example from current literature and discuss critical implications for prevention.
En ligne :	http://dx.doi.org/10.1017/s0954579408000369
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=543