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Auteur Dan J. STEIN |
Documents disponibles écrits par cet auteur (2)



Externalizing behavior in preschool children in a South African birth cohort: Predictive pathways in a high-risk context / Susan MALCOLM-SMITH in Development and Psychopathology, 35-2 (May 2023)
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[article]
Titre : Externalizing behavior in preschool children in a South African birth cohort: Predictive pathways in a high-risk context Type de document : Texte imprimé et/ou numérique Auteurs : Susan MALCOLM-SMITH, Auteur ; Marilyn T. LAKE, Auteur ; Akhona KRWECE, Auteur ; Christopher P. DU PLOOY, Auteur ; Nadia HOFFMAN, Auteur ; Kirsten A. DONALD, Auteur ; Heather J. ZAR, Auteur ; Dan J. STEIN, Auteur Article en page(s) : p.982-999 Langues : Anglais (eng) Mots-clés : preschool mental health externalizing behavior LMIC South Africa birth cohort Index. décimale : PER Périodiques Résumé : Mental health problems often begin in early childhood. However, the associations of various individual and contextual risk factors with mental health in the preschool period are incompletely understood, particularly in low- to middle-income countries (LMICs) where multiple risk factors co-exist. To address this gap, we prospectively followed 981 children in a South African birth cohort, the Drakenstein Child Health Study, assessing pre-and postnatal exposures and risk factors. The predictive value of these factors for child mental health (assessed by the Child Behavior Checklist) was modeled using structural equation modeling. We identified two key pathways to greater externalizing behavior: (1) prenatal exposure to substances (alcohol and smoking) directly predicted increased externalizing behavior (? = 0.24, p < 0.001); this relationship was partially mediated by an aspect of infant temperament (negative emotionality; ? = 0.05, p = 0.016); (2) lower socioeconomic status and associated maternal prenatal depression predicted more coercive parenting, which in turn predicted increased externalizing behavior (? = 0.18, p = 0.001). Findings in this high-risk LMIC cohort cohere with research from higher income contexts, and indicate the need to introduce integrated screening and intervention strategies for maternal prenatal substance use and depression, and promoting positive parenting across the preschool period. En ligne : http://dx.doi.org/10.1017/S095457942200027X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504
in Development and Psychopathology > 35-2 (May 2023) . - p.982-999[article] Externalizing behavior in preschool children in a South African birth cohort: Predictive pathways in a high-risk context [Texte imprimé et/ou numérique] / Susan MALCOLM-SMITH, Auteur ; Marilyn T. LAKE, Auteur ; Akhona KRWECE, Auteur ; Christopher P. DU PLOOY, Auteur ; Nadia HOFFMAN, Auteur ; Kirsten A. DONALD, Auteur ; Heather J. ZAR, Auteur ; Dan J. STEIN, Auteur . - p.982-999.
Langues : Anglais (eng)
in Development and Psychopathology > 35-2 (May 2023) . - p.982-999
Mots-clés : preschool mental health externalizing behavior LMIC South Africa birth cohort Index. décimale : PER Périodiques Résumé : Mental health problems often begin in early childhood. However, the associations of various individual and contextual risk factors with mental health in the preschool period are incompletely understood, particularly in low- to middle-income countries (LMICs) where multiple risk factors co-exist. To address this gap, we prospectively followed 981 children in a South African birth cohort, the Drakenstein Child Health Study, assessing pre-and postnatal exposures and risk factors. The predictive value of these factors for child mental health (assessed by the Child Behavior Checklist) was modeled using structural equation modeling. We identified two key pathways to greater externalizing behavior: (1) prenatal exposure to substances (alcohol and smoking) directly predicted increased externalizing behavior (? = 0.24, p < 0.001); this relationship was partially mediated by an aspect of infant temperament (negative emotionality; ? = 0.05, p = 0.016); (2) lower socioeconomic status and associated maternal prenatal depression predicted more coercive parenting, which in turn predicted increased externalizing behavior (? = 0.18, p = 0.001). Findings in this high-risk LMIC cohort cohere with research from higher income contexts, and indicate the need to introduce integrated screening and intervention strategies for maternal prenatal substance use and depression, and promoting positive parenting across the preschool period. En ligne : http://dx.doi.org/10.1017/S095457942200027X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies / Sarah J. HEANY in Development and Psychopathology, 30-4 (October 2018)
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[article]
Titre : The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Sarah J. HEANY, Auteur ; Nynke A. GROENEWOLD, Auteur ; Anne UHLMANN, Auteur ; Shareefa DALVIE, Auteur ; Dan J. STEIN, Auteur ; Samantha J. BROOKS, Auteur Article en page(s) : p.1475-1485 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood maltreatment, including abuse and neglect, may have sustained effects on the integrity and functioning of the brain, alter neurophysiological responsivity later in life, and predispose individuals toward psychiatric conditions involving socioaffective disturbances. This meta-analysis aims to quantify associations between self-reported childhood maltreatment and brain function in response to socioaffective cues in adults. Seventeen functional magnetic resonance imaging studies reporting on data from 848 individuals examined with the Childhood Trauma Questionnaire were included in a meta-analysis of whole-brain findings, or a review of region of interest findings. The spatial consistency of peak activations associated with maltreatment exposure was tested using activation likelihood estimation, using a threshold of p < .05 corrected for multiple comparisons. Adults exposed to childhood maltreatment showed significantly increased activation in the left superior frontal gyrus and left middle temporal gyrus, and decreased activation in the left superior parietal lobule and the left hippocampus. Although hyperresponsivity to socioaffective cues in the amygdala and ventral anterior cingulate cortex in correlation with maltreatment severity is a replicated finding in region of interest studies, null results are reported as well. The findings suggest that childhood maltreatment has sustained effects on brain function into adulthood, and highlight potential mechanisms for conveying vulnerability to development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Development and Psychopathology > 30-4 (October 2018) . - p.1475-1485[article] The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies [Texte imprimé et/ou numérique] / Sarah J. HEANY, Auteur ; Nynke A. GROENEWOLD, Auteur ; Anne UHLMANN, Auteur ; Shareefa DALVIE, Auteur ; Dan J. STEIN, Auteur ; Samantha J. BROOKS, Auteur . - p.1475-1485.
Langues : Anglais (eng)
in Development and Psychopathology > 30-4 (October 2018) . - p.1475-1485
Index. décimale : PER Périodiques Résumé : Childhood maltreatment, including abuse and neglect, may have sustained effects on the integrity and functioning of the brain, alter neurophysiological responsivity later in life, and predispose individuals toward psychiatric conditions involving socioaffective disturbances. This meta-analysis aims to quantify associations between self-reported childhood maltreatment and brain function in response to socioaffective cues in adults. Seventeen functional magnetic resonance imaging studies reporting on data from 848 individuals examined with the Childhood Trauma Questionnaire were included in a meta-analysis of whole-brain findings, or a review of region of interest findings. The spatial consistency of peak activations associated with maltreatment exposure was tested using activation likelihood estimation, using a threshold of p < .05 corrected for multiple comparisons. Adults exposed to childhood maltreatment showed significantly increased activation in the left superior frontal gyrus and left middle temporal gyrus, and decreased activation in the left superior parietal lobule and the left hippocampus. Although hyperresponsivity to socioaffective cues in the amygdala and ventral anterior cingulate cortex in correlation with maltreatment severity is a replicated finding in region of interest studies, null results are reported as well. The findings suggest that childhood maltreatment has sustained effects on brain function into adulthood, and highlight potential mechanisms for conveying vulnerability to development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368