[article]
| Titre : |
Brief report: A proof of concept study of altered magnocellular responses in autism spectrum disorder as assessed by contrasts functions for reversing checkerboards |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Jeffrey J. HUTSLER, Auteur |
| Article en page(s) : |
202573 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Visual evoked potentials (VEP) N75 P100 Peak amplitude Peak latency Autism spectrum disorders (ASD) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Alterations to early visual processing in autism spectrum disorder (ASD) may impact cognitive abilities and could serve as a potential neuromarker before behavioral symptoms appear. Behavioral research has suggested that visual alterations are linked to abnormalities in the magnocellular pathway. Methods Visual-evoked potentials (VEPs) were used to investigate early visual processing in adolescents with ASD. Two different-sized checkerboards (1° and .25°) displayed at four contrast levels (.025, .05, .1, and .98) were presented to seven ASD and eight neurotypical (NT) male subjects, between the ages of 10 to 15 years old. Peak amplitude and latency from the two earliest components-the N75 and P100-were analyzed. Results N75 amplitudes were largest at the highest contrast levels for both the small and large check sizes and did not differ according to diagnosis. For the P100, the ASD group consistently showed larger amplitudes than the NT subjects (p = .035), but there were no significant main effects or interactions involving diagnosis. Still, large effect sizes were found between ASD and NT subjects (d =.79-1.2) at the largest check size presented at lower contrast values. Latency differences between the subject groups were nonsignificant. Conclusions Group differences were most apparent at lower contrasts and large check sizes, pointing to a potential problem with early visual processing in the magnocellular pathway. Although additional research and a larger sample size is needed to confirm these findings, simple sensory measures may be useful as an indicator of ASD risk before the appearance of behavioral symptoms. |
| En ligne : |
https://doi.org/10.1016/j.reia.2025.202573 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 |
in Research in Autism > 123 (May 2025) . - 202573
[article] Brief report: A proof of concept study of altered magnocellular responses in autism spectrum disorder as assessed by contrasts functions for reversing checkerboards [Texte imprimé et/ou numérique] / Jeffrey J. HUTSLER, Auteur . - 202573. Langues : Anglais ( eng) in Research in Autism > 123 (May 2025) . - 202573
| Mots-clés : |
Visual evoked potentials (VEP) N75 P100 Peak amplitude Peak latency Autism spectrum disorders (ASD) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Alterations to early visual processing in autism spectrum disorder (ASD) may impact cognitive abilities and could serve as a potential neuromarker before behavioral symptoms appear. Behavioral research has suggested that visual alterations are linked to abnormalities in the magnocellular pathway. Methods Visual-evoked potentials (VEPs) were used to investigate early visual processing in adolescents with ASD. Two different-sized checkerboards (1° and .25°) displayed at four contrast levels (.025, .05, .1, and .98) were presented to seven ASD and eight neurotypical (NT) male subjects, between the ages of 10 to 15 years old. Peak amplitude and latency from the two earliest components-the N75 and P100-were analyzed. Results N75 amplitudes were largest at the highest contrast levels for both the small and large check sizes and did not differ according to diagnosis. For the P100, the ASD group consistently showed larger amplitudes than the NT subjects (p = .035), but there were no significant main effects or interactions involving diagnosis. Still, large effect sizes were found between ASD and NT subjects (d =.79-1.2) at the largest check size presented at lower contrast values. Latency differences between the subject groups were nonsignificant. Conclusions Group differences were most apparent at lower contrasts and large check sizes, pointing to a potential problem with early visual processing in the magnocellular pathway. Although additional research and a larger sample size is needed to confirm these findings, simple sensory measures may be useful as an indicator of ASD risk before the appearance of behavioral symptoms. |
| En ligne : |
https://doi.org/10.1016/j.reia.2025.202573 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 |
|
Brief report: A proof of concept study of altered magnocellular responses in autism spectrum disorder as assessed by contrasts functions for reversing checkerboards in Research in Autism, 123 (May 2025)
