[article]
| Titre : |
Age-Dependent Effects of Loss of Contactin-Associated Protein-Like 2, an Autism-Associated Gene, on the Acquisition and Recall of Fear Memory |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
A. BERNS, Auteur ; M. JONES, Auteur ; A. TOWNSEND, Auteur ; A. K. EAGEN, Auteur ; Sarah L. FERRI, Auteur ; D. R. LANGBEHN, Auteur ; H. JANOUSCHEK, Auteur |
| Article en page(s) : |
p.1011-1023 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
anxiety autism spectrum disorder CASPR2 Cntnap2 development fear fear conditioning memory |
| Index. décimale : |
PER Périodiques |
| Résumé : |
ABSTRACT The contactin-associated protein-like 2 (Cntnap2) gene is relevant to autism spectrum disorder (ASD), which is associated with age-specific structural alterations in limbic brain regions. The Cntnap2 gene encodes for the contactin-associated protein-like 2 (CASPR2) protein, and CASPR2 protein levels are high in the amygdala, a limbic region that is essential for the processing of fear and anxiety. In humans, reduced levels of this protein arising from CNTNAP2 mutations could potentially account for the autism-associated increase in fear and anxiety. Here, we report the extent to which loss of CASPR2 in mice contributes to the development of fear- and anxiety-related behaviors. Pavlovian fear conditioning experiments revealed that loss of CASPR2 has age-dependent effects on the acquisition of fear memory, recall of both cue-evoked and context-related fear memory, and stability of cue-evoked fear memory. Additionally, data from the elevated zero maze suggest that CASPR2 deficiency contributes to anxiety-related behaviors, especially in juvenile (29-day old) mice. These are the first reports of age-dependent effects of CASPR2 deficiency on fear and anxiety-related behaviors, and they set the stage for a better understanding of developmental alterations of fear and anxiety in ASD. |
| En ligne : |
https://doi.org/10.1002/aur.70034 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 |
in Autism Research > 18-5 (May 2025) . - p.1011-1023
[article] Age-Dependent Effects of Loss of Contactin-Associated Protein-Like 2, an Autism-Associated Gene, on the Acquisition and Recall of Fear Memory [Texte imprimé et/ou numérique] / A. BERNS, Auteur ; M. JONES, Auteur ; A. TOWNSEND, Auteur ; A. K. EAGEN, Auteur ; Sarah L. FERRI, Auteur ; D. R. LANGBEHN, Auteur ; H. JANOUSCHEK, Auteur . - p.1011-1023. Langues : Anglais ( eng) in Autism Research > 18-5 (May 2025) . - p.1011-1023
| Mots-clés : |
anxiety autism spectrum disorder CASPR2 Cntnap2 development fear fear conditioning memory |
| Index. décimale : |
PER Périodiques |
| Résumé : |
ABSTRACT The contactin-associated protein-like 2 (Cntnap2) gene is relevant to autism spectrum disorder (ASD), which is associated with age-specific structural alterations in limbic brain regions. The Cntnap2 gene encodes for the contactin-associated protein-like 2 (CASPR2) protein, and CASPR2 protein levels are high in the amygdala, a limbic region that is essential for the processing of fear and anxiety. In humans, reduced levels of this protein arising from CNTNAP2 mutations could potentially account for the autism-associated increase in fear and anxiety. Here, we report the extent to which loss of CASPR2 in mice contributes to the development of fear- and anxiety-related behaviors. Pavlovian fear conditioning experiments revealed that loss of CASPR2 has age-dependent effects on the acquisition of fear memory, recall of both cue-evoked and context-related fear memory, and stability of cue-evoked fear memory. Additionally, data from the elevated zero maze suggest that CASPR2 deficiency contributes to anxiety-related behaviors, especially in juvenile (29-day old) mice. These are the first reports of age-dependent effects of CASPR2 deficiency on fear and anxiety-related behaviors, and they set the stage for a better understanding of developmental alterations of fear and anxiety in ASD. |
| En ligne : |
https://doi.org/10.1002/aur.70034 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 |
|
Age-Dependent Effects of Loss of Contactin-Associated Protein-Like 2, an Autism-Associated Gene, on the Acquisition and Recall of Fear Memory in Autism Research, 18-5 (May 2025)
