[article]
| Titre : |
Prenatal and perinatal risk profiles of autism spectrum disorder with regression: Clinical, developmental, and phenotypic correlates |
| Type de document : |
texte imprimé |
| Auteurs : |
Ayşegül EFE, Auteur ; Duygu KABA, Auteur |
| Article en page(s) : |
202835 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorder Regression Perinatal risk factors Robson classification Developmental quotient Regression phenotypes |
| Résumé : |
Autism spectrum disorder with regression (ASD-R), defined by the loss of previously acquired skills, remains poorly understood yet crucial for early detection and intervention. This study examined prenatal, perinatal, neonatal, and parental psychosocial factors, along with developmental and phenotypic differences, in ASD-R compared with non-regressive ASD (ASD-NR) and neurotypical controls (NC). Participants (n = 164; aged 2–6 years) were consecutively referred and assessed using a standardized multidisciplinary protocol including direct observation, developmental testing, and structured caregiver interviews. Risk factors were extracted from medical records and classified using standardized systems, including the Robson classification. Maternal stress during pregnancy, postpartum psychiatric disorders, and comorbid global developmental delay significantly predicted ASD-R, whereas well-managed obstetric complications did not increase regression risk. ASD-R cases exhibited greater autism severity, distinctive stereotypy patterns—particularly in imitation, body use, and sensory responses—and lower developmental quotients at a younger mean age than previously reported. Regression patterns were heterogeneous: language-only regression was rare (10 %), combined language and social regression was common (52 %), and multidimensional regression occurred in 38 % of cases, supporting a broader conceptualization beyond language loss. Findings support a multifactorial model in which genetic susceptibility interacts with prenatal and perinatal stressors, potentially via immune and neuroinflammatory mechanisms, to shape regression trajectories. Early identification of these risk profiles could guide precision screening and targeted intervention strategies. Longitudinal, cross-cultural studies incorporating biological and environmental measures are needed to clarify causal mechanisms and optimize developmental outcomes for children with ASD-R. |
| En ligne : |
https://doi.org/10.1016/j.reia.2026.202835 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 |
in Research in Autism > 132 (April 2026) . - 202835
[article] Prenatal and perinatal risk profiles of autism spectrum disorder with regression: Clinical, developmental, and phenotypic correlates [texte imprimé] / Ayşegül EFE, Auteur ; Duygu KABA, Auteur . - 202835. Langues : Anglais ( eng) in Research in Autism > 132 (April 2026) . - 202835
| Mots-clés : |
Autism spectrum disorder Regression Perinatal risk factors Robson classification Developmental quotient Regression phenotypes |
| Résumé : |
Autism spectrum disorder with regression (ASD-R), defined by the loss of previously acquired skills, remains poorly understood yet crucial for early detection and intervention. This study examined prenatal, perinatal, neonatal, and parental psychosocial factors, along with developmental and phenotypic differences, in ASD-R compared with non-regressive ASD (ASD-NR) and neurotypical controls (NC). Participants (n = 164; aged 2–6 years) were consecutively referred and assessed using a standardized multidisciplinary protocol including direct observation, developmental testing, and structured caregiver interviews. Risk factors were extracted from medical records and classified using standardized systems, including the Robson classification. Maternal stress during pregnancy, postpartum psychiatric disorders, and comorbid global developmental delay significantly predicted ASD-R, whereas well-managed obstetric complications did not increase regression risk. ASD-R cases exhibited greater autism severity, distinctive stereotypy patterns—particularly in imitation, body use, and sensory responses—and lower developmental quotients at a younger mean age than previously reported. Regression patterns were heterogeneous: language-only regression was rare (10 %), combined language and social regression was common (52 %), and multidimensional regression occurred in 38 % of cases, supporting a broader conceptualization beyond language loss. Findings support a multifactorial model in which genetic susceptibility interacts with prenatal and perinatal stressors, potentially via immune and neuroinflammatory mechanisms, to shape regression trajectories. Early identification of these risk profiles could guide precision screening and targeted intervention strategies. Longitudinal, cross-cultural studies incorporating biological and environmental measures are needed to clarify causal mechanisms and optimize developmental outcomes for children with ASD-R. |
| En ligne : |
https://doi.org/10.1016/j.reia.2026.202835 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 |
|  |
Prenatal and perinatal risk profiles of autism spectrum disorder with regression: Clinical, developmental, and phenotypic correlates in Research in Autism, 132 (April 2026)
