[article]
| Titre : |
Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Johan F. SCHOEMAN, Auteur ; E. M. BRETT, Auteur ; A. A. ELYAS, Auteur ; P. T. LASCELLES, Auteur |
| Année de publication : |
1984 |
| Article en page(s) : |
p.749-755 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy. Children stabilised on standard doses of CBZ alone showed a ratio of CBZ-10,11-EPOX/CBZ of 18.92 +/- 8.08, expressed as a percentage of the CBZ concentration, while those on multiple-drug therapy (with the exception of benzodiazepines and phenobarbitone) showed both increased values of CBZ-10,11-EPOX/CBZ ratio and increased absolute concentrations of CBZ-10,11-EPOX in plasma. These changes correlated with clinical side-effects which could not be attributed to CBZ itself or to the other drugs administered concurrently. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 |
in Developmental Medicine & Child Neurology > 26-6 (December 1994) . - p.749-755
[article] Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug [Texte imprimé et/ou numérique] / Johan F. SCHOEMAN, Auteur ; E. M. BRETT, Auteur ; A. A. ELYAS, Auteur ; P. T. LASCELLES, Auteur . - 1984 . - p.749-755. Langues : Anglais ( eng) in Developmental Medicine & Child Neurology > 26-6 (December 1994) . - p.749-755
| Index. décimale : |
PER Périodiques |
| Résumé : |
A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy. Children stabilised on standard doses of CBZ alone showed a ratio of CBZ-10,11-EPOX/CBZ of 18.92 +/- 8.08, expressed as a percentage of the CBZ concentration, while those on multiple-drug therapy (with the exception of benzodiazepines and phenobarbitone) showed both increased values of CBZ-10,11-EPOX/CBZ ratio and increased absolute concentrations of CBZ-10,11-EPOX in plasma. These changes correlated with clinical side-effects which could not be attributed to CBZ itself or to the other drugs administered concurrently. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 |
|
Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug in Developmental Medicine & Child Neurology, 26-6 (December 1994)