[article]
| Titre : |
Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions |
| Type de document : |
texte imprimé |
| Auteurs : |
Seung Yun CHOI, Auteur ; Jinwoo LEE, Auteur ; Junghoon PARK, Auteur ; Eunji LEE, Auteur ; Bo-Gyeom KIM, Auteur ; Gakyung KIM, Auteur ; Yoonjung Yoonie JOO, Auteur ; Jiook CHA, Auteur |
| Article en page(s) : |
p.788-800 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Early-life stress ADHD gene-brain-environment vulnerability individual differences |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background This study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and resilience among children. Methods Utilizing longitudinal data from the Adolescent Brain Cognitive Development study (baseline: N?=?6,303, age?=?9.9), we applied Generalized Random Forest (GRF) to model the nonlinear relationships among genetic predispositions, brain features, and environmental factors. Results Significant individual variability was observed in children's ADHD symptoms post-stress, particularly at the 1-year and 2-year follow-ups. At the 1-year follow-up, increased vulnerability was indicated by heightened parental mental health problems and a lower polygenic risk score for smoking. By the 2-year follow-up, escalated parental mental health disorders, higher ADHD polygenic risk scores (PRS), and altered structural connectivity in the cognitive control network were significant contributors to individual differences. Conclusions These findings underscore the importance of integrating environmental, genetic, and neural variables to identify children vulnerable or resilient to developing ADHD symptoms following early-life stress. This study demonstrates how multimodal data combined with nonparametric machine learning can advance precision psychology and psychiatry, aiding targeted support for affected children. |
| En ligne : |
https://doi.org/10.1111/jcpp.70074 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 |
in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.788-800
[article] Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions [texte imprimé] / Seung Yun CHOI, Auteur ; Jinwoo LEE, Auteur ; Junghoon PARK, Auteur ; Eunji LEE, Auteur ; Bo-Gyeom KIM, Auteur ; Gakyung KIM, Auteur ; Yoonjung Yoonie JOO, Auteur ; Jiook CHA, Auteur . - p.788-800. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 67-5 (May 2026) . - p.788-800
| Mots-clés : |
Early-life stress ADHD gene-brain-environment vulnerability individual differences |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background This study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and resilience among children. Methods Utilizing longitudinal data from the Adolescent Brain Cognitive Development study (baseline: N?=?6,303, age?=?9.9), we applied Generalized Random Forest (GRF) to model the nonlinear relationships among genetic predispositions, brain features, and environmental factors. Results Significant individual variability was observed in children's ADHD symptoms post-stress, particularly at the 1-year and 2-year follow-ups. At the 1-year follow-up, increased vulnerability was indicated by heightened parental mental health problems and a lower polygenic risk score for smoking. By the 2-year follow-up, escalated parental mental health disorders, higher ADHD polygenic risk scores (PRS), and altered structural connectivity in the cognitive control network were significant contributors to individual differences. Conclusions These findings underscore the importance of integrating environmental, genetic, and neural variables to identify children vulnerable or resilient to developing ADHD symptoms following early-life stress. This study demonstrates how multimodal data combined with nonparametric machine learning can advance precision psychology and psychiatry, aiding targeted support for affected children. |
| En ligne : |
https://doi.org/10.1111/jcpp.70074 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 |
|  |
Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions in Journal of Child Psychology and Psychiatry, 67-5 (May 2026)
