[article]
| Titre : |
Reward-network connectivity in childhood predicts multi-domain dysregulation in adolescence |
| Type de document : |
texte imprimé |
| Auteurs : |
Eugenia GIAMPETRUZZI, Auteur ; Parmis KHOSRAVI, Auteur ; Katharina KIRCANSKI, Auteur ; Chase ANTONACCI, Auteur ; Daniel S. PINE, Auteur ; Ian H. GOTLIB, Auteur |
| Article en page(s) : |
p.1348-1360 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Dysregulation profile reward network connectivity adolescence |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Multi-domain dysregulation in adolescence, indexed by co-occurring affective, cognitive, and behavioural difficulties, is a robust transdiagnostic risk factor. However, its developmental course and neural antecedents are poorly understood. Given heightened emotional reactivity and impulsivity in adolescence, alterations in reward-network connectivity may represent an early neural marker of risk. Methods Adolescents completed four assessments approximately two years apart between ages 9?13 and 15?18?years. Multi-domain dysregulation was assessed at each wave using the Youth Self-Report Dysregulation Profile (YSR-DP), computed as the sum of the anxious/depressed, aggressive behaviour, and attention problems subscales. Resting-state fMRI was acquired at baseline (Mage?=?11.34?years). Piecewise linear mixed-effects models (N?=?211) characterized trajectories of YSR-DP scores across adolescence. Principal component scores indexing a Latent Dysregulation Factor were used to derive residualised change in dysregulation, and regression analyses (N?=?94) tested whether baseline reward-network connectivity predicted this change. Results YSR-DP scores declined from late childhood to early adolescence, increased from early to mid-adolescence, and then stabilized in late adolescence. Weaker connectivity within the reward network in late childhood predicted greater increases in the latent dysregulation factor from early to mid-adolescence, above and beyond baseline dysregulation. Connectivity in seven large-scale control networks did not predict changes in dysregulation. Conclusions Multi-domain dysregulation follows a nonlinear trajectory across adolescence, and weaker reward-network connectivity in childhood prospectively predicts subsequent escalation of this phenotype. Prevention and intervention efforts may benefit from targeting reward processing and regulatory skills in late childhood and early adolescence. |
| En ligne : |
https://doi.org/10.1111/jcpp.70143 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 |
in Journal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1348-1360
[article] Reward-network connectivity in childhood predicts multi-domain dysregulation in adolescence [texte imprimé] / Eugenia GIAMPETRUZZI, Auteur ; Parmis KHOSRAVI, Auteur ; Katharina KIRCANSKI, Auteur ; Chase ANTONACCI, Auteur ; Daniel S. PINE, Auteur ; Ian H. GOTLIB, Auteur . - p.1348-1360. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1348-1360
| Mots-clés : |
Dysregulation profile reward network connectivity adolescence |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Multi-domain dysregulation in adolescence, indexed by co-occurring affective, cognitive, and behavioural difficulties, is a robust transdiagnostic risk factor. However, its developmental course and neural antecedents are poorly understood. Given heightened emotional reactivity and impulsivity in adolescence, alterations in reward-network connectivity may represent an early neural marker of risk. Methods Adolescents completed four assessments approximately two years apart between ages 9?13 and 15?18?years. Multi-domain dysregulation was assessed at each wave using the Youth Self-Report Dysregulation Profile (YSR-DP), computed as the sum of the anxious/depressed, aggressive behaviour, and attention problems subscales. Resting-state fMRI was acquired at baseline (Mage?=?11.34?years). Piecewise linear mixed-effects models (N?=?211) characterized trajectories of YSR-DP scores across adolescence. Principal component scores indexing a Latent Dysregulation Factor were used to derive residualised change in dysregulation, and regression analyses (N?=?94) tested whether baseline reward-network connectivity predicted this change. Results YSR-DP scores declined from late childhood to early adolescence, increased from early to mid-adolescence, and then stabilized in late adolescence. Weaker connectivity within the reward network in late childhood predicted greater increases in the latent dysregulation factor from early to mid-adolescence, above and beyond baseline dysregulation. Connectivity in seven large-scale control networks did not predict changes in dysregulation. Conclusions Multi-domain dysregulation follows a nonlinear trajectory across adolescence, and weaker reward-network connectivity in childhood prospectively predicts subsequent escalation of this phenotype. Prevention and intervention efforts may benefit from targeting reward processing and regulatory skills in late childhood and early adolescence. |
| En ligne : |
https://doi.org/10.1111/jcpp.70143 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 |
|  |
Reward-network connectivity in childhood predicts multi-domain dysregulation in adolescence in Journal of Child Psychology and Psychiatry, 67-8 (August 2026)
