Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life / Carmen Maria SCHRODER in Journal of Autism and Developmental Disorders, 49-8 (August 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3218-3230 Titre : Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life Type de document : Texte imprimé et/ou numérique Auteurs : Carmen Maria SCHRODER, Auteur ; B. A. MALOW, Auteur ; A. MARAS, Auteur ; R. D. MELMED, Auteur ; R. L. FINDLING, Auteur ; J. BREDDY, Auteur ; T. NIR, Auteur ; S. SHAHMOON, Auteur ; N. ZISAPEL, Auteur ; P. GRINGRAS, Auteur Article en page(s) : p.3218-3230 Langues : Anglais (eng) Mots-clés : Autism  Behavior  Children (pediatric)  Prolonged-release melatonin  Sleep Index. décimale : PER Périodiques Résumé : A randomized, 13-weeks, placebo-controlled double-blind study in 125 subjects aged 2-17.5 years with Autism Spectrum Disorder or Smith-Magenis syndrome and insomnia demonstrated efficacy and safety of easily-swallowed prolonged-release melatonin mini-tablets (PedPRM; 2-5 mg) in improving sleep duration and onset. Treatment effects on child behavior and caregiver's quality of life were evaluated. PedPRM treatment resulted in significant improvement in externalizing but not internalizing behavior (Strengths and Difficulties questionnaire; SDQ) compared to placebo (p = 0.021) with clinically-relevant improvements in 53.7% of PedPRM-treated versus 27.6% of placebo-treated subjects (p = 0.008). Caregivers' quality of life also improved with PedPRM versus placebo (p = 0.010) and correlated with the change in total SDQ (p = 0.0005). PedPRM alleviates insomnia-related difficulties, particularly externalizing behavior in the children, subsequently improving caregivers' quality of life. En ligne : http://dx.doi.org/10.1007/s10803-019-04046-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life [Texte imprimé et/ou numérique] / Carmen Maria SCHRODER, Auteur ; B. A. MALOW, Auteur ; A. MARAS, Auteur ; R. D. MELMED, Auteur ; R. L. FINDLING, Auteur ; J. BREDDY, Auteur ; T. NIR, Auteur ; S. SHAHMOON, Auteur ; N. ZISAPEL, Auteur ; P. GRINGRAS, Auteur . - p.3218-3230. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3218-3230 Mots-clés : Autism  Behavior  Children (pediatric)  Prolonged-release melatonin  Sleep Index. décimale : PER Périodiques Résumé : A randomized, 13-weeks, placebo-controlled double-blind study in 125 subjects aged 2-17.5 years with Autism Spectrum Disorder or Smith-Magenis syndrome and insomnia demonstrated efficacy and safety of easily-swallowed prolonged-release melatonin mini-tablets (PedPRM; 2-5 mg) in improving sleep duration and onset. Treatment effects on child behavior and caregiver's quality of life were evaluated. PedPRM treatment resulted in significant improvement in externalizing but not internalizing behavior (Strengths and Difficulties questionnaire; SDQ) compared to placebo (p = 0.021) with clinically-relevant improvements in 53.7% of PedPRM-treated versus 27.6% of placebo-treated subjects (p = 0.008). Caregivers' quality of life also improved with PedPRM versus placebo (p = 0.010) and correlated with the change in total SDQ (p = 0.0005). PedPRM alleviates insomnia-related difficulties, particularly externalizing behavior in the children, subsequently improving caregivers' quality of life. En ligne : http://dx.doi.org/10.1007/s10803-019-04046-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

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