Role of Environmental Exposure to Toxins and Microbial Infections in Autism / Rajendram V. RAJNARAYANAN in Autism Insights, (February 2014)  

Public ISBD [article]  inAutism Insights > (February 2014) . - p.15-25 Titre : Role of Environmental Exposure to Toxins and Microbial Infections in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Rajendram V. RAJNARAYANAN, Auteur ; Nataliya KOSTYUK, Auteur ; Hari H.P. COHLY, Auteur Article en page(s) : p.15-25 Langues : Anglais (eng) Mots-clés : environmental chemicals  toxins  microbial infections  autism Index. décimale : PER Périodiques Résumé : Autism is a complex developmental neurological disorder causing impaired function and structure of brain development. According to a recent report from the Centers for Disease Control and Prevention (CDC), autism is estimated to affect 1 in 88 children in USA.1 In spite of several reports linking prenatal exposure to environmental toxins and to microbial agents via infections to a spectrum of autism and autism-like disorders, to date, neither the associated risk factor nor the pathophysiological mechanisms have been established unequivocally. The impact of these environmental agents is believed to be similar to that of other neuropsychiatric disorders. Earlier, we have reported the impact and immunological implications of mercury and viral infections in autism. In this review, we highlight the current incidence of autism, discuss brain development in autism, present the prominent features of neuroanatomy in autism, describe neurodegenerative findings in autistic individuals, summarize the hypotheses to explain autism, and provide a perspective of the molecular events in autism and autism spectrum disorders (ASD). The early events that trigger this complex cluster of neurological disorders may involve the breach of cellular interface, which leads to the influx of water which in turn damages the developing neurons during the early stages of brain development. Alternatively, neurodegenerative disorders can be caused by the interaction of environmental agents like heavy metals with transport proteins like aquaporins and gap junction protein complexes embedded in the neuronal network during synaptogenesis. En ligne : https://dx.doi.org/10.4137/AUI.S13839 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Role of Environmental Exposure to Toxins and Microbial Infections in Autism [Texte imprimé et/ou numérique] / Rajendram V. RAJNARAYANAN, Auteur ; Nataliya KOSTYUK, Auteur ; Hari H.P. COHLY, Auteur . - p.15-25. Langues : Anglais (eng) in Autism Insights > (February 2014) . - p.15-25 Mots-clés : environmental chemicals  toxins  microbial infections  autism Index. décimale : PER Périodiques Résumé : Autism is a complex developmental neurological disorder causing impaired function and structure of brain development. According to a recent report from the Centers for Disease Control and Prevention (CDC), autism is estimated to affect 1 in 88 children in USA.1 In spite of several reports linking prenatal exposure to environmental toxins and to microbial agents via infections to a spectrum of autism and autism-like disorders, to date, neither the associated risk factor nor the pathophysiological mechanisms have been established unequivocally. The impact of these environmental agents is believed to be similar to that of other neuropsychiatric disorders. Earlier, we have reported the impact and immunological implications of mercury and viral infections in autism. In this review, we highlight the current incidence of autism, discuss brain development in autism, present the prominent features of neuroanatomy in autism, describe neurodegenerative findings in autistic individuals, summarize the hypotheses to explain autism, and provide a perspective of the molecular events in autism and autism spectrum disorders (ASD). The early events that trigger this complex cluster of neurological disorders may involve the breach of cellular interface, which leads to the influx of water which in turn damages the developing neurons during the early stages of brain development. Alternatively, neurodegenerative disorders can be caused by the interaction of environmental agents like heavy metals with transport proteins like aquaporins and gap junction protein complexes embedded in the neuronal network during synaptogenesis. En ligne : https://dx.doi.org/10.4137/AUI.S13839 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

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