Handedness and corpus callosal morphology in Williams syndrome / Marilee A. MARTENS in Development and Psychopathology, 25-1 (February 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-1 (February 2013) . - p.253-260 Titre : Handedness and corpus callosal morphology in Williams syndrome Type de document : texte imprimé Auteurs : Marilee A. MARTENS, Auteur ; Sarah J. WILSON, Auteur ; Jian CHEN, Auteur ; Amanda G. WOOD, Auteur ; David C. REUTENS, Auteur Article en page(s) : p.253-260 Index. décimale : PER Périodiques Résumé : Williams syndrome is a neurodevelopmental genetic disorder caused by a hemizygous deletion on chromosome 7q11.23, resulting in atypical brain structure and function, including abnormal morphology of the corpus callosum. An influence of handedness on the size of the corpus callosum has been observed in studies of typical individuals, but handedness has not been taken into account in studies of callosal morphology in Williams syndrome. We hypothesized that callosal area is smaller and the size of the splenium and isthmus is reduced in individuals with Williams syndrome compared to healthy controls, and examined age, sex, and handedness effects on corpus callosal area. Structural magnetic resonance imaging scans were obtained on 25 individuals with Williams syndrome (18 right-handed, 7 left-handed) and 25 matched controls. We found that callosal thickness was significantly reduced in the splenium of Williams syndrome individuals compared to controls. We also found novel evidence that the callosal area was smaller in left-handed participants with Williams syndrome than their right-handed counterparts, with opposite findings observed in the control group. This novel finding may be associated with LIM-kinase hemizygosity, a characteristic of Williams syndrome. The findings may have significant clinical implications in future explorations of the Williams syndrome cognitive phenotype. En ligne : http://dx.doi.org/10.1017/S0954579412001009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190 [article] Handedness and corpus callosal morphology in Williams syndrome [texte imprimé] / Marilee A. MARTENS, Auteur ; Sarah J. WILSON, Auteur ; Jian CHEN, Auteur ; Amanda G. WOOD, Auteur ; David C. REUTENS, Auteur . - p.253-260. in Development and Psychopathology > 25-1 (February 2013) . - p.253-260 Index. décimale : PER Périodiques Résumé : Williams syndrome is a neurodevelopmental genetic disorder caused by a hemizygous deletion on chromosome 7q11.23, resulting in atypical brain structure and function, including abnormal morphology of the corpus callosum. An influence of handedness on the size of the corpus callosum has been observed in studies of typical individuals, but handedness has not been taken into account in studies of callosal morphology in Williams syndrome. We hypothesized that callosal area is smaller and the size of the splenium and isthmus is reduced in individuals with Williams syndrome compared to healthy controls, and examined age, sex, and handedness effects on corpus callosal area. Structural magnetic resonance imaging scans were obtained on 25 individuals with Williams syndrome (18 right-handed, 7 left-handed) and 25 matched controls. We found that callosal thickness was significantly reduced in the splenium of Williams syndrome individuals compared to controls. We also found novel evidence that the callosal area was smaller in left-handed participants with Williams syndrome than their right-handed counterparts, with opposite findings observed in the control group. This novel finding may be associated with LIM-kinase hemizygosity, a characteristic of Williams syndrome. The findings may have significant clinical implications in future explorations of the Williams syndrome cognitive phenotype. En ligne : http://dx.doi.org/10.1017/S0954579412001009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190

Research Review: Williams syndrome: a critical review of the cognitive, behavioral, and neuroanatomical phenotype / Marilee A. MARTENS in Journal of Child Psychology and Psychiatry, 49-6 (June 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-6 (June 2008) . - p.576-608 Titre : Research Review: Williams syndrome: a critical review of the cognitive, behavioral, and neuroanatomical phenotype Type de document : texte imprimé Auteurs : Marilee A. MARTENS, Auteur ; Sarah J. WILSON, Auteur ; David C. REUTENS, Auteur Année de publication : 2008 Article en page(s) : p.576-608 Langues : Anglais (eng) Mots-clés : Williams-syndrome review phenotype cognition language music social-behavior Index. décimale : PER Périodiques Résumé : This review critically examines the research findings which characterize the cognitive, behavioral, and neuroanatomical features of Williams syndrome (WS). This article analyzes 178 published studies in the WS literature covering the following areas: 1) General intelligence, 2) Language skills, 3) Visuospatial and face processing skills, 4) Behavior patterns and hypersociability, 5) Musical abilities, and 6) Brain structure and function. We identify methodological issues relating to small sample size, use and type of control groups, and multiple measures of task performance. Previously described ‘peaks’ within the cognitive profile are closely examined to assess their veracity. This review highlights the need for methodologically sound studies that utilize multiple comparison groups, developmental trajectories, and longitudinal analyses to examine the WS phenotype, as well as those that link brain structure and function to the cognitive and behavioral phenotype of WS individuals. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01887.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Research Review: Williams syndrome: a critical review of the cognitive, behavioral, and neuroanatomical phenotype [texte imprimé] / Marilee A. MARTENS, Auteur ; Sarah J. WILSON, Auteur ; David C. REUTENS, Auteur . - 2008 . - p.576-608. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-6 (June 2008) . - p.576-608 Mots-clés : Williams-syndrome review phenotype cognition language music social-behavior Index. décimale : PER Périodiques Résumé : This review critically examines the research findings which characterize the cognitive, behavioral, and neuroanatomical features of Williams syndrome (WS). This article analyzes 178 published studies in the WS literature covering the following areas: 1) General intelligence, 2) Language skills, 3) Visuospatial and face processing skills, 4) Behavior patterns and hypersociability, 5) Musical abilities, and 6) Brain structure and function. We identify methodological issues relating to small sample size, use and type of control groups, and multiple measures of task performance. Previously described ‘peaks’ within the cognitive profile are closely examined to assess their veracity. This review highlights the need for methodologically sound studies that utilize multiple comparison groups, developmental trajectories, and longitudinal analyses to examine the WS phenotype, as well as those that link brain structure and function to the cognitive and behavioral phenotype of WS individuals. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01887.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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