Developmental aspects of focal epilepsies of childhood treated by neurosurgery / Janet LINDSAY in Developmental Medicine & Child Neurology, 26-5 (October 1984)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 26-5 (October 1984) . - p.574-587 Titre : Developmental aspects of focal epilepsies of childhood treated by neurosurgery Type de document : Texte imprimé et/ou numérique Auteurs : Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur ; Gilbert H. GLASER, Auteur Année de publication : 1984 Article en page(s) : p.574-587 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Data on 50 patients treated surgically for intractable focal epilepsy were analysed. There were 10 hemispherectomies, 32 temporal lobectomies and eight operations to other areas of the brain. The median age at operation was 14 years. 29 patients were found to have mesial temporal sclerosis or sclerotic hemispheres and 17 had alien tissue and one sclerosis with heterotopia. No lesion was found in three cases. The nature of the first seizure was found to relate significantly to pathology. 30 patients had suffered an early convulsion. Between the convulsive insult and the onset of focal epilepsy there was a silent interval, the duration of which was biased by sex and side of lesion. The remaining 20 patients, of whom a highly significant number had alien tissue, had not had an early convulsion before the onset of focal epilepsy. The importance of accurate clinical histories is stressed. Clinical considerations alone predicted the pathology and laterality of the lesion in more than half the series. Regular EEG recordings and repeat scanning were found to be important investigations. Major disorders of behaviour had occurred in 44 patients. As adults, the series were free of severe psychiatric symptoms, but many required years of careful rehabilitation. 31 children had been excluded from normal schools before operation. Postoperatively, many patients continued their education in normal schools. Some required basic remedial teaching, others successfully undertook higher education and training. 49 patients benefited over-all from neurosurgical treatment. 34 had no more habitual epilepsy at all. Full global gains often took at least five years to achieve. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582 [article] Developmental aspects of focal epilepsies of childhood treated by neurosurgery [Texte imprimé et/ou numérique] / Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur ; Gilbert H. GLASER, Auteur . - 1984 . - p.574-587. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 26-5 (October 1984) . - p.574-587 Index. décimale : PER Périodiques Résumé : Data on 50 patients treated surgically for intractable focal epilepsy were analysed. There were 10 hemispherectomies, 32 temporal lobectomies and eight operations to other areas of the brain. The median age at operation was 14 years. 29 patients were found to have mesial temporal sclerosis or sclerotic hemispheres and 17 had alien tissue and one sclerosis with heterotopia. No lesion was found in three cases. The nature of the first seizure was found to relate significantly to pathology. 30 patients had suffered an early convulsion. Between the convulsive insult and the onset of focal epilepsy there was a silent interval, the duration of which was biased by sex and side of lesion. The remaining 20 patients, of whom a highly significant number had alien tissue, had not had an early convulsion before the onset of focal epilepsy. The importance of accurate clinical histories is stressed. Clinical considerations alone predicted the pathology and laterality of the lesion in more than half the series. Regular EEG recordings and repeat scanning were found to be important investigations. Major disorders of behaviour had occurred in 44 patients. As adults, the series were free of severe psychiatric symptoms, but many required years of careful rehabilitation. 31 children had been excluded from normal schools before operation. Postoperatively, many patients continued their education in normal schools. Some required basic remedial teaching, others successfully undertook higher education and training. 49 patients benefited over-all from neurosurgical treatment. 34 had no more habitual epilepsy at all. Full global gains often took at least five years to achieve. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582

Hemispherectomy for childhood epilepsy: a 36-year study / Janet LINDSAY in Developmental Medicine & Child Neurology, 29-5 (October 1987)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 29-5 (October 1987) . - p.592-600 Titre : Hemispherectomy for childhood epilepsy: a 36-year study Type de document : Texte imprimé et/ou numérique Auteurs : Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur Année de publication : 1987 Article en page(s) : p.592-600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Between 1950 and the present day 17 patients who had been treated for hemiplegic epilepsy by hemispherectomy were followed up. The outcomes of surgery in terms of survival, arrest of dementia, relief from gross disorders of behaviour and from habitual epilepsy were uniformly good. It is concluded that hemispherectomy has an enduring rôle in the treatment of hemiplegic epilepsy for patients who are carefully selected, prepared and postoperatively rehabilitated. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=628 [article] Hemispherectomy for childhood epilepsy: a 36-year study [Texte imprimé et/ou numérique] / Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur . - 1987 . - p.592-600. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 29-5 (October 1987) . - p.592-600 Index. décimale : PER Périodiques Résumé : Between 1950 and the present day 17 patients who had been treated for hemiplegic epilepsy by hemispherectomy were followed up. The outcomes of surgery in terms of survival, arrest of dementia, relief from gross disorders of behaviour and from habitual epilepsy were uniformly good. It is concluded that hemispherectomy has an enduring rôle in the treatment of hemiplegic epilepsy for patients who are carefully selected, prepared and postoperatively rehabilitated. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=628

Long-term outcome in children with temporal lobe seizures. I: Social outcome and childhood factors / Janet LINDSAY in Developmental Medicine & Child Neurology, 21-3 (June 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-3 (June 1979) . - p.285-298 Titre : Long-term outcome in children with temporal lobe seizures. I: Social outcome and childhood factors Type de document : Texte imprimé et/ou numérique Auteurs : Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur Année de publication : 1979 Article en page(s) : p.285-298 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One-hundred children, diagnosed as having temporal lobe epilepsy and reported on in 1966, have been followed into adult life. In this 1977 survey they have been coded into four social outcome categories, A, B, C and D. A: 33 per cent are found to be seizure-free and independent; B: 21 per cent are socially and economically independent but are receiving anticonvulsant treatment and are not necessarily seizure-free; C: O9 per cent are dependent either on their parents or in institutions; D: 5 per cent died under the age of 15. Biological factors ascertained and coded in childhood are related to adult outcome. Eight adverse factors emerged: an IQ below 90, onset of seizures before 2 years 4 months, five or more grand mal attacks, temporal lobe seizure frequency of one per day or more, a left-sided focus, the hyperkinetic syndrome, catastrophic rage and special schooling. The presence of first-degree relatives with seizure disorders was a good prognostic sign. Disorderly homes in childhood did not significantly affect adult outcome. All but one of those achieving Group A status had received normal schooling. In general, the prognosis for children with limbic seizures is clear before the end of adolescence. A simple count of the number of childhood adverse factors predicts adult outcome at a high level of significance. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 [article] Long-term outcome in children with temporal lobe seizures. I: Social outcome and childhood factors [Texte imprimé et/ou numérique] / Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur . - 1979 . - p.285-298. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-3 (June 1979) . - p.285-298 Index. décimale : PER Périodiques Résumé : One-hundred children, diagnosed as having temporal lobe epilepsy and reported on in 1966, have been followed into adult life. In this 1977 survey they have been coded into four social outcome categories, A, B, C and D. A: 33 per cent are found to be seizure-free and independent; B: 21 per cent are socially and economically independent but are receiving anticonvulsant treatment and are not necessarily seizure-free; C: O9 per cent are dependent either on their parents or in institutions; D: 5 per cent died under the age of 15. Biological factors ascertained and coded in childhood are related to adult outcome. Eight adverse factors emerged: an IQ below 90, onset of seizures before 2 years 4 months, five or more grand mal attacks, temporal lobe seizure frequency of one per day or more, a left-sided focus, the hyperkinetic syndrome, catastrophic rage and special schooling. The presence of first-degree relatives with seizure disorders was a good prognostic sign. Disorderly homes in childhood did not significantly affect adult outcome. All but one of those achieving Group A status had received normal schooling. In general, the prognosis for children with limbic seizures is clear before the end of adolescence. A simple count of the number of childhood adverse factors predicts adult outcome at a high level of significance. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495

Long-term outcome in children with temporal lobe seizures. II: Marriage, parenthood and sexual indifference / Janet LINDSAY in Developmental Medicine & Child Neurology, 21-4 (August 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-4 (August 1979) . - p.433-440 Titre : Long-term outcome in children with temporal lobe seizures. II: Marriage, parenthood and sexual indifference Type de document : Texte imprimé et/ou numérique Auteurs : Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur Année de publication : 1979 Article en page(s) : p.433-440 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One-hundred unselected children with clinical and EEG evidence of temporal lobe seizures were followed into adult life. Data related to marriage and reproduction are analysed. Female survivors, if not totally handicapped, are nearly all married; surviving males who are not totally handicapped more often remain single. Early remission of seizures in males is associated with marriage: seizures continuing through adolescence are associated with sexual appetitive indifference. The female probands have produced children at a rate three times greater than the male probands. The findings have implications for understanding the development of male secual appetite. The epidemiology and genetics of these forms of seizures must take account of much greater fitness on the distaff side of the pedigree. The likelihood of marriage and parenthood would appear to rest on a few biological factors usually recognisable before the end of childhood. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=497 [article] Long-term outcome in children with temporal lobe seizures. II: Marriage, parenthood and sexual indifference [Texte imprimé et/ou numérique] / Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur . - 1979 . - p.433-440. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-4 (August 1979) . - p.433-440 Index. décimale : PER Périodiques Résumé : One-hundred unselected children with clinical and EEG evidence of temporal lobe seizures were followed into adult life. Data related to marriage and reproduction are analysed. Female survivors, if not totally handicapped, are nearly all married; surviving males who are not totally handicapped more often remain single. Early remission of seizures in males is associated with marriage: seizures continuing through adolescence are associated with sexual appetitive indifference. The female probands have produced children at a rate three times greater than the male probands. The findings have implications for understanding the development of male secual appetite. The epidemiology and genetics of these forms of seizures must take account of much greater fitness on the distaff side of the pedigree. The likelihood of marriage and parenthood would appear to rest on a few biological factors usually recognisable before the end of childhood. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=497

Long-term outcome in children with temporal lobe seizures. III: Psychiatric aspects in childhood and adult life / Janet LINDSAY in Developmental Medicine & Child Neurology, 21-5 (October 1979)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 21-5 (October 1979) . - p.630-636 Titre : Long-term outcome in children with temporal lobe seizures. III: Psychiatric aspects in childhood and adult life Type de document : Texte imprimé et/ou numérique Auteurs : Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur Année de publication : 1979 Article en page(s) : p.630-636 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One hundred children with temporal lobe epilepsy were followed into adult life. 85 per cent had had psychiatric problems in childhood. The occurrence of overt psychiatric disorder in adult life was low: of those survivors who were not gravely mentally retarded, 70 per cent were regarded as psychiatrically healthy. Overt schizophreniform psychosis has developed in 10 per cent of survivors. Males with continuing epilepsy and left-sided foci were at special risk: 30 per cent of such patients had become psychotic. No patient coded as having a right-sided focus in 1964 had become psychotic by 1977. Though 26 patients had had grossly disordered childhood homes, this factor had no significant relation to adult psychiatric disorder. Antisocial conduct marked the adult life of 12 patients. Their childhood codes showed that male sex, a focus contralateral to the preferred hand, and unremittent epilepsy marked this group. Low intelligence and childhood rages were also prominent. Treated neurotic and depressive illness was quite uncommon. Only five survivors have fallen into this category. Those patients escaping psychiatric ill-health are often notably extraverted and successful. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Long-term outcome in children with temporal lobe seizures. III: Psychiatric aspects in childhood and adult life [Texte imprimé et/ou numérique] / Janet LINDSAY, Auteur ; Christopher OUNSTED, Auteur ; Peronelle RICHARDS, Auteur . - 1979 . - p.630-636. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 21-5 (October 1979) . - p.630-636 Index. décimale : PER Périodiques Résumé : One hundred children with temporal lobe epilepsy were followed into adult life. 85 per cent had had psychiatric problems in childhood. The occurrence of overt psychiatric disorder in adult life was low: of those survivors who were not gravely mentally retarded, 70 per cent were regarded as psychiatrically healthy. Overt schizophreniform psychosis has developed in 10 per cent of survivors. Males with continuing epilepsy and left-sided foci were at special risk: 30 per cent of such patients had become psychotic. No patient coded as having a right-sided focus in 1964 had become psychotic by 1977. Though 26 patients had had grossly disordered childhood homes, this factor had no significant relation to adult psychiatric disorder. Antisocial conduct marked the adult life of 12 patients. Their childhood codes showed that male sex, a focus contralateral to the preferred hand, and unremittent epilepsy marked this group. Low intelligence and childhood rages were also prominent. Treated neurotic and depressive illness was quite uncommon. Only five survivors have fallen into this category. Those patients escaping psychiatric ill-health are often notably extraverted and successful. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Long-term outcome in children with temporal lobe seizures. IV: Genetic factors, febrile convulsions and the remission of seizures / Janet LINDSAY in Developmental Medicine & Child Neurology, 22-4 (August 1980)

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Long-term outcome in children with temporal lobe seizures. V: Indications and contra-indications for neurosurgery / Janet LINDSAY in Developmental Medicine & Child Neurology, 26-1 (February 1984)

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Preventing febrile convulsions / Christopher OUNSTED in Developmental Medicine & Child Neurology, 20-6 (December 1978)

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Single-cause Attribution / Christopher OUNSTED in Developmental Medicine & Child Neurology, 30-2 (April 1988)

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