An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social–emotional mediators / Amy L. BYRD in Development and Psychopathology, 33-4 (October 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1248-1263 Titre : An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social–emotional mediators Type de document : texte imprimé Auteurs : Amy L. BYRD, Auteur ; Irene TUNG, Auteur ; Stephen D. MANUCK, Auteur ; Vera VINE, Auteur ; Michelle HORNER, Auteur ; Alison E. HIPWELL, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.1248-1263 Langues : Anglais (eng) Mots-clés : callousness  emotion dysregulation  maltreatment  oxytocin  psychopathology Index. décimale : PER Périodiques Résumé : Early threat exposure is a transdiagnostic risk factor for psychopathology, and evidence suggests that genetic variation in the oxytocin receptor (OXTR) moderates this association. However, it is unclear if this gene-by-environment (G×E) interaction is tied to unique risk for disorder-specific outcomes or instead increases shared risk for general psychopathology. Moreover, little is known about how this G×E interaction increases risk. The current study utilized a prospective, longitudinal sample of females (n = 2,020) to examine: (a) whether the interaction between early threat exposure and OXTR variation (rs53576, rs2254298) confers risk for disorder-specific outcomes (depression, anxiety, borderline and antisocial personality disorders) and/or general psychopathology in early adulthood; and (b) whether social–emotional deficits (emotion dysregulation, callousness, attachment quality) during adolescence constitute mediating mechanisms. Consistent with hypotheses, the interactive effects of early threat exposure and OXTR variation (rs53576) predicted general psychopathology, with threat-exposed women carrying at least one copy of the rs53576 A-allele at greatest risk. This interaction was mediated via emotional dysregulation in adolescence, with threat-exposed A-allele carriers demonstrating greater emotion dysregulation, and greater emotion dysregulation predicting general psychopathology in early adulthood. Findings suggest that this G×E places women at risk for a broad range of psychopathology via effects on emotion dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579420000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social–emotional mediators [texte imprimé] / Amy L. BYRD, Auteur ; Irene TUNG, Auteur ; Stephen D. MANUCK, Auteur ; Vera VINE, Auteur ; Michelle HORNER, Auteur ; Alison E. HIPWELL, Auteur ; Stephanie D. STEPP, Auteur . - p.1248-1263. Langues : Anglais (eng) in Development and Psychopathology > 33-4 (October 2021) . - p.1248-1263 Mots-clés : callousness  emotion dysregulation  maltreatment  oxytocin  psychopathology Index. décimale : PER Périodiques Résumé : Early threat exposure is a transdiagnostic risk factor for psychopathology, and evidence suggests that genetic variation in the oxytocin receptor (OXTR) moderates this association. However, it is unclear if this gene-by-environment (G×E) interaction is tied to unique risk for disorder-specific outcomes or instead increases shared risk for general psychopathology. Moreover, little is known about how this G×E interaction increases risk. The current study utilized a prospective, longitudinal sample of females (n = 2,020) to examine: (a) whether the interaction between early threat exposure and OXTR variation (rs53576, rs2254298) confers risk for disorder-specific outcomes (depression, anxiety, borderline and antisocial personality disorders) and/or general psychopathology in early adulthood; and (b) whether social–emotional deficits (emotion dysregulation, callousness, attachment quality) during adolescence constitute mediating mechanisms. Consistent with hypotheses, the interactive effects of early threat exposure and OXTR variation (rs53576) predicted general psychopathology, with threat-exposed women carrying at least one copy of the rs53576 A-allele at greatest risk. This interaction was mediated via emotional dysregulation in adolescence, with threat-exposed A-allele carriers demonstrating greater emotion dysregulation, and greater emotion dysregulation predicting general psychopathology in early adulthood. Findings suggest that this G×E places women at risk for a broad range of psychopathology via effects on emotion dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579420000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Momentary borderline personality disorder symptoms in youth as a function of parental invalidation and youth-perceived support / Salome VANWOERDEN in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.178-186 Titre : Momentary borderline personality disorder symptoms in youth as a function of parental invalidation and youth-perceived support Type de document : texte imprimé Auteurs : Salome VANWOERDEN, Auteur ; Amy L. BYRD, Auteur ; Vera VINE, Auteur ; Joseph E. BEENEY, Auteur ; Lori N. SCOTT, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.178-186 Langues : Anglais (eng) Mots-clés : Borderline personality disorder  adolescence  ecological momentary assessment  parental invalidation Index. décimale : PER Périodiques Résumé : BACKGROUND: Parental invalidation is central to etiological models of borderline personality disorder (BPD). Previous studies relied on retrospective accounts or laboratory observations to examine these associations. There is a dearth of research assessing these constructs in daily life, and limited studies have tested the effect of parental invalidation on BPD symptoms during early adolescence, when BPD onsets. The current study took a dynamic approach to assess parents' validating and invalidating behavior and its effect on youths' BPD symptom expression in daily life, while accounting for parent-perceived helpfulness of these behaviors and youth-perceived support. METHODS: A psychiatric sample of 162 early adolescents (age range = 10-14 years; 47% female) and their parent completed a four-day ecological momentary assessment study. Parents reported on the use of validating and invalidating (e.g. punishing and ignoring) behaviors during parent-child conflict, as well as perceived helpfulness of these behaviors. Youth reported on their BPD symptoms and perceived parental support. Multilevel models were used to test the between- and within-person effects of parents' validating and invalidating behaviors, parent-perceived helpfulness and youth-perceived support, and their interaction on youth's momentary expression of BPD symptoms. RESULTS: At the between-person level, invalidating behaviors, specifically punishing behaviors, were related to greater BPD symptoms in daily life, while ignoring behaviors were associated with fewer BPD symptoms. Youth-perceived support predicted fewer BPD symptoms. CONCLUSIONS: Results underscore the importance of parental invalidation for the expression of BPD symptoms in daily life and also highlight the importance of youth's subjective experience of parental support. Findings are discussed in terms of etiological and intervention models that emphasize a dyadic framework. En ligne : http://dx.doi.org/10.1111/jcpp.13443 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Momentary borderline personality disorder symptoms in youth as a function of parental invalidation and youth-perceived support [texte imprimé] / Salome VANWOERDEN, Auteur ; Amy L. BYRD, Auteur ; Vera VINE, Auteur ; Joseph E. BEENEY, Auteur ; Lori N. SCOTT, Auteur ; Stephanie D. STEPP, Auteur . - p.178-186. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.178-186 Mots-clés : Borderline personality disorder  adolescence  ecological momentary assessment  parental invalidation Index. décimale : PER Périodiques Résumé : BACKGROUND: Parental invalidation is central to etiological models of borderline personality disorder (BPD). Previous studies relied on retrospective accounts or laboratory observations to examine these associations. There is a dearth of research assessing these constructs in daily life, and limited studies have tested the effect of parental invalidation on BPD symptoms during early adolescence, when BPD onsets. The current study took a dynamic approach to assess parents' validating and invalidating behavior and its effect on youths' BPD symptom expression in daily life, while accounting for parent-perceived helpfulness of these behaviors and youth-perceived support. METHODS: A psychiatric sample of 162 early adolescents (age range = 10-14 years; 47% female) and their parent completed a four-day ecological momentary assessment study. Parents reported on the use of validating and invalidating (e.g. punishing and ignoring) behaviors during parent-child conflict, as well as perceived helpfulness of these behaviors. Youth reported on their BPD symptoms and perceived parental support. Multilevel models were used to test the between- and within-person effects of parents' validating and invalidating behaviors, parent-perceived helpfulness and youth-perceived support, and their interaction on youth's momentary expression of BPD symptoms. RESULTS: At the between-person level, invalidating behaviors, specifically punishing behaviors, were related to greater BPD symptoms in daily life, while ignoring behaviors were associated with fewer BPD symptoms. Youth-perceived support predicted fewer BPD symptoms. CONCLUSIONS: Results underscore the importance of parental invalidation for the expression of BPD symptoms in daily life and also highlight the importance of youth's subjective experience of parental support. Findings are discussed in terms of etiological and intervention models that emphasize a dyadic framework. En ligne : http://dx.doi.org/10.1111/jcpp.13443 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

The role of youths' cardiac autonomic balance and parental responses to youth emotion in vulnerability to borderline personality disorder development / Vera VINE ; Amy L. BYRD ; J. Richard JENNINGS ; Stephanie D. STEPP in Development and Psychopathology, 36-2 (May 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-2 (May 2024) . - p.993-1004 Titre : The role of youths' cardiac autonomic balance and parental responses to youth emotion in vulnerability to borderline personality disorder development Type de document : texte imprimé Auteurs : Vera VINE, Auteur ; Amy L. BYRD, Auteur ; J. Richard JENNINGS, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.993-1004 Langues : Anglais (eng) Mots-clés : adolescence  borderline personality disorder  cardiac autonomic balance  cardiac regulatory capacity  emotion socialization Index. décimale : PER Périodiques Résumé : Developmental models of borderline personality disorder (BPD) emphasize the effects of youths' biological vulnerabilities and their experiences of parental responses to emotion, as well as the interaction between these two elements. The current study evaluated the independent and interactive effects of two indices of autonomic nervous system response and parental responses to youth negative emotions on severity and exacerbation of youths' BPD features during the transition to adolescence. The sample consisted of 162 psychiatric youth (10-14 years; 47.2% female) and their parents. At baseline, youth and their parents completed a lab-based conflict discussion during which parasympathetic and sympathetic nervous system response were measured and indices of sympathetic-parasympathetic balance and coactivation/coinhibition were calculated. Youth also reported on supportive and non-supportive parental responses. At baseline and after 9 months, youth self-reported on their BPD features. Results demonstrated that shifting toward sympathetic dominance independently predicted exacerbation of BPD across 9 months. Additionally, fewer experiences of supportive parental responses and more non-supportive parental responses were associated with greater severity of BPD features in youth. This study highlights the role of autonomic response to parent-child conflict as well as the significance of parental responses to youth emotion for the development of BPD during this developmental window. En ligne : https://dx.doi.org/10.1017/S095457942300024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 [article] The role of youths' cardiac autonomic balance and parental responses to youth emotion in vulnerability to borderline personality disorder development [texte imprimé] / Vera VINE, Auteur ; Amy L. BYRD, Auteur ; J. Richard JENNINGS, Auteur ; Stephanie D. STEPP, Auteur . - p.993-1004. Langues : Anglais (eng) in Development and Psychopathology > 36-2 (May 2024) . - p.993-1004 Mots-clés : adolescence  borderline personality disorder  cardiac autonomic balance  cardiac regulatory capacity  emotion socialization Index. décimale : PER Périodiques Résumé : Developmental models of borderline personality disorder (BPD) emphasize the effects of youths' biological vulnerabilities and their experiences of parental responses to emotion, as well as the interaction between these two elements. The current study evaluated the independent and interactive effects of two indices of autonomic nervous system response and parental responses to youth negative emotions on severity and exacerbation of youths' BPD features during the transition to adolescence. The sample consisted of 162 psychiatric youth (10-14 years; 47.2% female) and their parents. At baseline, youth and their parents completed a lab-based conflict discussion during which parasympathetic and sympathetic nervous system response were measured and indices of sympathetic-parasympathetic balance and coactivation/coinhibition were calculated. Youth also reported on supportive and non-supportive parental responses. At baseline and after 9 months, youth self-reported on their BPD features. Results demonstrated that shifting toward sympathetic dominance independently predicted exacerbation of BPD across 9 months. Additionally, fewer experiences of supportive parental responses and more non-supportive parental responses were associated with greater severity of BPD features in youth. This study highlights the role of autonomic response to parent-child conflict as well as the significance of parental responses to youth emotion for the development of BPD during this developmental window. En ligne : https://dx.doi.org/10.1017/S095457942300024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

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