An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social–emotional mediators / Amy L. BYRD in Development and Psychopathology, 33-4 (October 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1248-1263 Titre : An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social–emotional mediators Type de document : Texte imprimé et/ou numérique Auteurs : Amy L. BYRD, Auteur ; Irene TUNG, Auteur ; Stephen D. MANUCK, Auteur ; Vera VINE, Auteur ; Michelle HORNER, Auteur ; Alison E. HIPWELL, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.1248-1263 Langues : Anglais (eng) Mots-clés : callousness  emotion dysregulation  maltreatment  oxytocin  psychopathology Index. décimale : PER Périodiques Résumé : Early threat exposure is a transdiagnostic risk factor for psychopathology, and evidence suggests that genetic variation in the oxytocin receptor (OXTR) moderates this association. However, it is unclear if this gene-by-environment (G×E) interaction is tied to unique risk for disorder-specific outcomes or instead increases shared risk for general psychopathology. Moreover, little is known about how this G×E interaction increases risk. The current study utilized a prospective, longitudinal sample of females (n = 2,020) to examine: (a) whether the interaction between early threat exposure and OXTR variation (rs53576, rs2254298) confers risk for disorder-specific outcomes (depression, anxiety, borderline and antisocial personality disorders) and/or general psychopathology in early adulthood; and (b) whether social–emotional deficits (emotion dysregulation, callousness, attachment quality) during adolescence constitute mediating mechanisms. Consistent with hypotheses, the interactive effects of early threat exposure and OXTR variation (rs53576) predicted general psychopathology, with threat-exposed women carrying at least one copy of the rs53576 A-allele at greatest risk. This interaction was mediated via emotional dysregulation in adolescence, with threat-exposed A-allele carriers demonstrating greater emotion dysregulation, and greater emotion dysregulation predicting general psychopathology in early adulthood. Findings suggest that this G×E places women at risk for a broad range of psychopathology via effects on emotion dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579420000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social–emotional mediators [Texte imprimé et/ou numérique] / Amy L. BYRD, Auteur ; Irene TUNG, Auteur ; Stephen D. MANUCK, Auteur ; Vera VINE, Auteur ; Michelle HORNER, Auteur ; Alison E. HIPWELL, Auteur ; Stephanie D. STEPP, Auteur . - p.1248-1263. Langues : Anglais (eng) in Development and Psychopathology > 33-4 (October 2021) . - p.1248-1263 Mots-clés : callousness  emotion dysregulation  maltreatment  oxytocin  psychopathology Index. décimale : PER Périodiques Résumé : Early threat exposure is a transdiagnostic risk factor for psychopathology, and evidence suggests that genetic variation in the oxytocin receptor (OXTR) moderates this association. However, it is unclear if this gene-by-environment (G×E) interaction is tied to unique risk for disorder-specific outcomes or instead increases shared risk for general psychopathology. Moreover, little is known about how this G×E interaction increases risk. The current study utilized a prospective, longitudinal sample of females (n = 2,020) to examine: (a) whether the interaction between early threat exposure and OXTR variation (rs53576, rs2254298) confers risk for disorder-specific outcomes (depression, anxiety, borderline and antisocial personality disorders) and/or general psychopathology in early adulthood; and (b) whether social–emotional deficits (emotion dysregulation, callousness, attachment quality) during adolescence constitute mediating mechanisms. Consistent with hypotheses, the interactive effects of early threat exposure and OXTR variation (rs53576) predicted general psychopathology, with threat-exposed women carrying at least one copy of the rs53576 A-allele at greatest risk. This interaction was mediated via emotional dysregulation in adolescence, with threat-exposed A-allele carriers demonstrating greater emotion dysregulation, and greater emotion dysregulation predicting general psychopathology in early adulthood. Findings suggest that this G×E places women at risk for a broad range of psychopathology via effects on emotion dysregulation. En ligne : http://dx.doi.org/10.1017/S0954579420000462 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

The role of youths' cardiac autonomic balance and parental responses to youth emotion in vulnerability to borderline personality disorder development / Vera VINE ; Amy L. BYRD ; J. Richard JENNINGS ; Stephanie D. STEPP in Development and Psychopathology, 36-2 (May 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-2 (May 2024) . - p.993-1004 Titre : The role of youths' cardiac autonomic balance and parental responses to youth emotion in vulnerability to borderline personality disorder development Type de document : Texte imprimé et/ou numérique Auteurs : Vera VINE, Auteur ; Amy L. BYRD, Auteur ; J. Richard JENNINGS, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.993-1004 Langues : Anglais (eng) Mots-clés : adolescence  borderline personality disorder  cardiac autonomic balance  cardiac regulatory capacity  emotion socialization Index. décimale : PER Périodiques Résumé : Developmental models of borderline personality disorder (BPD) emphasize the effects of youths' biological vulnerabilities and their experiences of parental responses to emotion, as well as the interaction between these two elements. The current study evaluated the independent and interactive effects of two indices of autonomic nervous system response and parental responses to youth negative emotions on severity and exacerbation of youths' BPD features during the transition to adolescence. The sample consisted of 162 psychiatric youth (10-14 years; 47.2% female) and their parents. At baseline, youth and their parents completed a lab-based conflict discussion during which parasympathetic and sympathetic nervous system response were measured and indices of sympathetic-parasympathetic balance and coactivation/coinhibition were calculated. Youth also reported on supportive and non-supportive parental responses. At baseline and after 9 months, youth self-reported on their BPD features. Results demonstrated that shifting toward sympathetic dominance independently predicted exacerbation of BPD across 9 months. Additionally, fewer experiences of supportive parental responses and more non-supportive parental responses were associated with greater severity of BPD features in youth. This study highlights the role of autonomic response to parent-child conflict as well as the significance of parental responses to youth emotion for the development of BPD during this developmental window. En ligne : https://dx.doi.org/10.1017/S095457942300024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 [article] The role of youths' cardiac autonomic balance and parental responses to youth emotion in vulnerability to borderline personality disorder development [Texte imprimé et/ou numérique] / Vera VINE, Auteur ; Amy L. BYRD, Auteur ; J. Richard JENNINGS, Auteur ; Stephanie D. STEPP, Auteur . - p.993-1004. Langues : Anglais (eng) in Development and Psychopathology > 36-2 (May 2024) . - p.993-1004 Mots-clés : adolescence  borderline personality disorder  cardiac autonomic balance  cardiac regulatory capacity  emotion socialization Index. décimale : PER Périodiques Résumé : Developmental models of borderline personality disorder (BPD) emphasize the effects of youths' biological vulnerabilities and their experiences of parental responses to emotion, as well as the interaction between these two elements. The current study evaluated the independent and interactive effects of two indices of autonomic nervous system response and parental responses to youth negative emotions on severity and exacerbation of youths' BPD features during the transition to adolescence. The sample consisted of 162 psychiatric youth (10-14 years; 47.2% female) and their parents. At baseline, youth and their parents completed a lab-based conflict discussion during which parasympathetic and sympathetic nervous system response were measured and indices of sympathetic-parasympathetic balance and coactivation/coinhibition were calculated. Youth also reported on supportive and non-supportive parental responses. At baseline and after 9 months, youth self-reported on their BPD features. Results demonstrated that shifting toward sympathetic dominance independently predicted exacerbation of BPD across 9 months. Additionally, fewer experiences of supportive parental responses and more non-supportive parental responses were associated with greater severity of BPD features in youth. This study highlights the role of autonomic response to parent-child conflict as well as the significance of parental responses to youth emotion for the development of BPD during this developmental window. En ligne : https://dx.doi.org/10.1017/S095457942300024X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

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