Early indicators of response to transdiagnostic treatment of pediatric anxiety and depression / Michelle ROZENMAN ; Araceli GONZALEZ ; David A. BRENT ; Giovanna PORTA ; Frances L. LYNCH ; John F. DICKERSON ; V. Robin WEERSING in Journal of Child Psychology and Psychiatry, 64-12 (December 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1689-1698 Titre : Early indicators of response to transdiagnostic treatment of pediatric anxiety and depression Type de document : Texte imprimé et/ou numérique Auteurs : Michelle ROZENMAN, Auteur ; Araceli GONZALEZ, Auteur ; David A. BRENT, Auteur ; Giovanna PORTA, Auteur ; Frances L. LYNCH, Auteur ; John F. DICKERSON, Auteur ; V. Robin WEERSING, Auteur Article en page(s) : p.1689-1698 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Pediatric anxiety and depression are prevalent, impairing, and highly comorbid. Available evidence-based treatments have an average response rate of 60%. One path to increasing response may be to identify likely non-responders midway through treatment to adjust course prior to completing an episode of care. The aims of this study, thus, were to identify predictors of post-intervention response assessing (a) mid-treatment symptom severity, (b) session-by-session treatment process factors, and (c) a model optimizing the combination of these. Method Data were drawn from the treatment arm (N=95, ages 8-16) of a randomized transdiagnostic intervention trial (Msessions=11.2). Mid-point measures of youth- and parent-reported anxiety and depression were collected, and therapists rated homework completion, youth and parent engagement, and youth therapeutic alliance at each session. Logistic regression was used to predict response on the Clinical Global Impression Improvement Scale (CGI-I ?2) rated by independent evaluators masked to treatment condition. Results Mid-point symptom measures were significant predictors of treatment response, as were therapist-ratings of youth and parent engagement, therapeutic alliance, and homework completion. Therapist ratings were significant when tested as mean ratings summing across the first eight sessions of treatment (all ps<.004) and at individual session points (all ps?<0.05). A combined prediction model included youth-reported anxiety, parent-reported depression, youth engagement at Session 2, and parent engagement at Session 8. This model correctly classified 76.5% of youth as non-responders and 91.3% as responders at post-treatment (Nagelkerke R2=.59, ?2 (4, 80)=46.54, p<.001). Conclusion This study provides initial evidence that response to transdiagnostic intervention for pediatric anxiety and depression may be reliably predicted by mid-point. These data may serve as foundational evidence to develop adaptive treatment strategies to personalize intervention, correct treatment course, and optimize outcomes for youth with anxiety and depression. En ligne : https://doi.org/10.1111/jcpp.13881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Early indicators of response to transdiagnostic treatment of pediatric anxiety and depression [Texte imprimé et/ou numérique] / Michelle ROZENMAN, Auteur ; Araceli GONZALEZ, Auteur ; David A. BRENT, Auteur ; Giovanna PORTA, Auteur ; Frances L. LYNCH, Auteur ; John F. DICKERSON, Auteur ; V. Robin WEERSING, Auteur . - p.1689-1698. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-12 (December 2023) . - p.1689-1698 Index. décimale : PER Périodiques Résumé : Background Pediatric anxiety and depression are prevalent, impairing, and highly comorbid. Available evidence-based treatments have an average response rate of 60%. One path to increasing response may be to identify likely non-responders midway through treatment to adjust course prior to completing an episode of care. The aims of this study, thus, were to identify predictors of post-intervention response assessing (a) mid-treatment symptom severity, (b) session-by-session treatment process factors, and (c) a model optimizing the combination of these. Method Data were drawn from the treatment arm (N=95, ages 8-16) of a randomized transdiagnostic intervention trial (Msessions=11.2). Mid-point measures of youth- and parent-reported anxiety and depression were collected, and therapists rated homework completion, youth and parent engagement, and youth therapeutic alliance at each session. Logistic regression was used to predict response on the Clinical Global Impression Improvement Scale (CGI-I ?2) rated by independent evaluators masked to treatment condition. Results Mid-point symptom measures were significant predictors of treatment response, as were therapist-ratings of youth and parent engagement, therapeutic alliance, and homework completion. Therapist ratings were significant when tested as mean ratings summing across the first eight sessions of treatment (all ps<.004) and at individual session points (all ps?<0.05). A combined prediction model included youth-reported anxiety, parent-reported depression, youth engagement at Session 2, and parent engagement at Session 8. This model correctly classified 76.5% of youth as non-responders and 91.3% as responders at post-treatment (Nagelkerke R2=.59, ?2 (4, 80)=46.54, p<.001). Conclusion This study provides initial evidence that response to transdiagnostic intervention for pediatric anxiety and depression may be reliably predicted by mid-point. These data may serve as foundational evidence to develop adaptive treatment strategies to personalize intervention, correct treatment course, and optimize outcomes for youth with anxiety and depression. En ligne : https://doi.org/10.1111/jcpp.13881 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

The transdiagnostic origins of anxiety and depression during the pediatric period: Linking NIMH research domain criteria (RDoC) constructs to ecological systems / Jenalee R. DOOM in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1599-1619 Titre : The transdiagnostic origins of anxiety and depression during the pediatric period: Linking NIMH research domain criteria (RDoC) constructs to ecological systems Type de document : Texte imprimé et/ou numérique Auteurs : Jenalee R. DOOM, Auteur ; Michelle ROZENMAN, Auteur ; Kathryn R. FOX, Auteur ; Tiffany PHU, Auteur ; Anni R. SUBAR, Auteur ; Deborah SEOK, Auteur ; Kenia M. RIVERA, Auteur Article en page(s) : p.1599-1619 Langues : Anglais (eng) Mots-clés : anxiety  depression  ecological systems theory  RDoC  youth Index. décimale : PER Périodiques Résumé : In the last decade, an abundance of research has utilized the National Institute of Mental Health (NIMH) research domain criteria (RDoC) framework to examine mechanisms underlying anxiety and depression in youth. However, relatively little work has examined how these mechanistic intrapersonal processes intersect with context during childhood and adolescence. The current paper covers reviews and meta-analyses that have linked RDoC-relevant constructs to ecological systems in internalizing problems in youth. Specifically, cognitive, biological, and affective factors within the RDoC framework were examined. Based on these reviews and some of the original empirical research they cover, we highlight the integral role of ecological factors to the RDoC framework in predicting onset and maintenance of internalizing problems in youth. Specific recommendations are provided for researchers using the RDoC framework to inform future research integrating ecological systems and development. We advocate for future research and research funding to focus on better integration of the environment and development into the RDoC framework. En ligne : http://dx.doi.org/10.1017/S0954579421000559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] The transdiagnostic origins of anxiety and depression during the pediatric period: Linking NIMH research domain criteria (RDoC) constructs to ecological systems [Texte imprimé et/ou numérique] / Jenalee R. DOOM, Auteur ; Michelle ROZENMAN, Auteur ; Kathryn R. FOX, Auteur ; Tiffany PHU, Auteur ; Anni R. SUBAR, Auteur ; Deborah SEOK, Auteur ; Kenia M. RIVERA, Auteur . - p.1599-1619. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1599-1619 Mots-clés : anxiety  depression  ecological systems theory  RDoC  youth Index. décimale : PER Périodiques Résumé : In the last decade, an abundance of research has utilized the National Institute of Mental Health (NIMH) research domain criteria (RDoC) framework to examine mechanisms underlying anxiety and depression in youth. However, relatively little work has examined how these mechanistic intrapersonal processes intersect with context during childhood and adolescence. The current paper covers reviews and meta-analyses that have linked RDoC-relevant constructs to ecological systems in internalizing problems in youth. Specifically, cognitive, biological, and affective factors within the RDoC framework were examined. Based on these reviews and some of the original empirical research they cover, we highlight the integral role of ecological factors to the RDoC framework in predicting onset and maintenance of internalizing problems in youth. Specific recommendations are provided for researchers using the RDoC framework to inform future research integrating ecological systems and development. We advocate for future research and research funding to focus on better integration of the environment and development into the RDoC framework. En ligne : http://dx.doi.org/10.1017/S0954579421000559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

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