Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder / Chen BAI in Autism Research, 16-6 (June 2023)  

Public ISBD [article]  inAutism Research > 16-6 (June 2023) . - p.1124-1137 Titre : Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chen BAI, Auteur ; Yunlei Wang, Auteur ; Yan ZHANG, Auteur ; Xianna Wang, Auteur ; Zhenbo Chen, Auteur ; Weiyong Yu, Auteur ; Haojie Zhang, Auteur ; Xingzhu Li, Auteur ; Kaixuan Zhu, Auteur ; Yuxiang Wang, Auteur ; Tong Zhang, Auteur Article en page(s) : p.1124-1137 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  functional connectivity  gray matter volume  support vector machine Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is associated with abnormal brain imaging findings, but descriptions thereof are inconsistent. The aim of the present study was to investigate brain abnormalities in young children with ASD using a combination of structural and functional brain magnetic resonance imaging (MRI). Structural and resting-state functional MRI was performed in 67 children with ASD (aged 2?7?years) and 39 age-matched typically developing (TD) controls. Voxel-based morphometry was used to evaluate differences in brain structure between groups. Topologic parameters of the functional brain network were compared by graph theoretic analysis and network connectomes were compared with network-based statistics. A support vector machine (SVM) was used to discriminate between ASD and TD groups. Results demonstrated young children with ASD had increased gray matter volumes (GMVs) in the right medial superior frontal gyrus and left fusiform gyrus compared with the TD group. The ASD group had altered subnetwork connectivity in frontal and temporal lobes and other social cognition-related brain regions. Functional connectivity in the left superior temporal gyrus and left temporal pole of the middle temporal gyrus was positively correlated with adaptability and language developmental quotient (DQ) in children with ASD. The combination of the brain structural and functional features had 86.2% accuracy in discriminating between ASD and TD. The present study shows that young children with ASD have altered GMVs and functional networks in social cognition-related brain regions, which are potential neuroimaging biomarkers for ASD. En ligne : https://doi.org/10.1002/aur.2936 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 [article] Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder [Texte imprimé et/ou numérique] / Chen BAI, Auteur ; Yunlei Wang, Auteur ; Yan ZHANG, Auteur ; Xianna Wang, Auteur ; Zhenbo Chen, Auteur ; Weiyong Yu, Auteur ; Haojie Zhang, Auteur ; Xingzhu Li, Auteur ; Kaixuan Zhu, Auteur ; Yuxiang Wang, Auteur ; Tong Zhang, Auteur . - p.1124-1137. Langues : Anglais (eng) in Autism Research > 16-6 (June 2023) . - p.1124-1137 Mots-clés : autism spectrum disorder  functional connectivity  gray matter volume  support vector machine Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is associated with abnormal brain imaging findings, but descriptions thereof are inconsistent. The aim of the present study was to investigate brain abnormalities in young children with ASD using a combination of structural and functional brain magnetic resonance imaging (MRI). Structural and resting-state functional MRI was performed in 67 children with ASD (aged 2?7?years) and 39 age-matched typically developing (TD) controls. Voxel-based morphometry was used to evaluate differences in brain structure between groups. Topologic parameters of the functional brain network were compared by graph theoretic analysis and network connectomes were compared with network-based statistics. A support vector machine (SVM) was used to discriminate between ASD and TD groups. Results demonstrated young children with ASD had increased gray matter volumes (GMVs) in the right medial superior frontal gyrus and left fusiform gyrus compared with the TD group. The ASD group had altered subnetwork connectivity in frontal and temporal lobes and other social cognition-related brain regions. Functional connectivity in the left superior temporal gyrus and left temporal pole of the middle temporal gyrus was positively correlated with adaptability and language developmental quotient (DQ) in children with ASD. The combination of the brain structural and functional features had 86.2% accuracy in discriminating between ASD and TD. The present study shows that young children with ASD have altered GMVs and functional networks in social cognition-related brain regions, which are potential neuroimaging biomarkers for ASD. En ligne : https://doi.org/10.1002/aur.2936 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507

Effects of sex, race, and ethnicity on primary and subspecialty healthcare use by autistic children in Florida: A longitudinal retrospective cohort study (2012?2018) / Amber M. ANGELL in Research in Autism Spectrum Disorders, 94 (June 2022)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 94 (June 2022) . - 101951 Titre : Effects of sex, race, and ethnicity on primary and subspecialty healthcare use by autistic children in Florida: A longitudinal retrospective cohort study (2012?2018) Type de document : Texte imprimé et/ou numérique Auteurs : Amber M. ANGELL, Auteur ; Deepthi S. VARMA, Auteur ; Alexis DEAVENPORT-SAMAN, Auteur ; Larry YIN, Auteur ; Olga SOLOMON, Auteur ; Chen BAI, Auteur ; Baiming ZOU, Auteur Article en page(s) : 101951 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Sex/gender  Healthcare utilization Index. décimale : PER Périodiques Résumé : Background Autistic children and youth have high rates of co-occurring conditions,but little is known about how autism subgroups (girls, non-White children) access healthcare to treat them. The purpose of this longitudinal retrospective cohort study was to investigate differences by sex, race, and ethnicity in non-acute (primary and subspecialty) healthcare use by autistic children and youth. Method We used the OneFlorida Data Trust to measure healthcare use for 82,566 autistic children ages 1?21 (2012?2018). We investigated (1) the odds of using any healthcare and (2) annual healthcare usage rates. We adopted a logistic regression and multiple linear regression for each of the dependent variables (total non-acute, primary care, gastroenterology (GI), developmental-behavioral pediatrics (DBP), psychiatry/psychology, neurology, and total subspecialty visits), adjusting for potential confounders (sex, race, ethnicity, age at visit, insurance type, urbanicity, and co-occurring conditions). Results Autistic boys had significantly higher odds of any neurology and psychiatry/psychology visits, but lower annual rates of primary care, GI, and neurology visits. Black/African American autistic children had significantly higher odds of any primary care, DBP, and neurology visits, but lower odds of any GI visits, and lower annual rates of primary care, GI, DBP, and neurology visits. Hispanic/Latinx autistic children had significantly higher odds of any primary care, DBP, and neurology visits, but lower odds of psychiatry/psychology visits; and higher annual rates of neurology visits, but lower annual rates of GI, DBP, and psychiatry/psychology visits. Conclusions We found significant differences by sex, race, and ethnicity in non-acute healthcare use by autistic children. En ligne : https://doi.org/10.1016/j.rasd.2022.101951 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Effects of sex, race, and ethnicity on primary and subspecialty healthcare use by autistic children in Florida: A longitudinal retrospective cohort study (2012?2018) [Texte imprimé et/ou numérique] / Amber M. ANGELL, Auteur ; Deepthi S. VARMA, Auteur ; Alexis DEAVENPORT-SAMAN, Auteur ; Larry YIN, Auteur ; Olga SOLOMON, Auteur ; Chen BAI, Auteur ; Baiming ZOU, Auteur . - 101951. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 94 (June 2022) . - 101951 Mots-clés : Autism spectrum disorders  Sex/gender  Healthcare utilization Index. décimale : PER Périodiques Résumé : Background Autistic children and youth have high rates of co-occurring conditions,but little is known about how autism subgroups (girls, non-White children) access healthcare to treat them. The purpose of this longitudinal retrospective cohort study was to investigate differences by sex, race, and ethnicity in non-acute (primary and subspecialty) healthcare use by autistic children and youth. Method We used the OneFlorida Data Trust to measure healthcare use for 82,566 autistic children ages 1?21 (2012?2018). We investigated (1) the odds of using any healthcare and (2) annual healthcare usage rates. We adopted a logistic regression and multiple linear regression for each of the dependent variables (total non-acute, primary care, gastroenterology (GI), developmental-behavioral pediatrics (DBP), psychiatry/psychology, neurology, and total subspecialty visits), adjusting for potential confounders (sex, race, ethnicity, age at visit, insurance type, urbanicity, and co-occurring conditions). Results Autistic boys had significantly higher odds of any neurology and psychiatry/psychology visits, but lower annual rates of primary care, GI, and neurology visits. Black/African American autistic children had significantly higher odds of any primary care, DBP, and neurology visits, but lower odds of any GI visits, and lower annual rates of primary care, GI, DBP, and neurology visits. Hispanic/Latinx autistic children had significantly higher odds of any primary care, DBP, and neurology visits, but lower odds of psychiatry/psychology visits; and higher annual rates of neurology visits, but lower annual rates of GI, DBP, and psychiatry/psychology visits. Conclusions We found significant differences by sex, race, and ethnicity in non-acute healthcare use by autistic children. En ligne : https://doi.org/10.1016/j.rasd.2022.101951 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

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