[article] 
inJournal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1197-1210

Titre :	Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Katharina DWORZYNSKI, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur
Année de publication :	2009
Article en page(s) :	p.1197-1210
Langues :	Anglais (eng)
Mots-clés :	Autism-spectrum-disorders Symptom-domains Twins
Index. décimale :	PER Périodiques
Résumé :	Factor structure and relationship between core features of autism (social impairments, communication difficulties, and restricted, repetitive behaviours or interests (RRBIs)) were explored in 189 children from the Twins Early Development Study, diagnosed with autistic spectrum disorders (ASDs) using the Development and Wellbeing Assessment (DAWBA; Goodman et al. in J Child Psychol Psyc 41:645–655, 2000). A bottom-up approach (analysis 1) used principal component factor analysis of DAWBA items indicating five factors, the first three mapping on the triad. In analysis 2, applying top-down DSM-IV criteria, correlations between domains were modest, strongest between social and communication difficulties. Cross-twin cross-trait correlations suggested small shared genetic effects between RRBIs and other symptoms. These findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-009-0736-1
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789

[article] Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study [Texte imprimé et/ou numérique] / Katharina DWORZYNSKI, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur ; Angelica RONALD, Auteur . - 2009 . - p.1197-1210.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1197-1210

Mots-clés :	Autism-spectrum-disorders Symptom-domains Twins
Index. décimale :	PER Périodiques
Résumé :	Factor structure and relationship between core features of autism (social impairments, communication difficulties, and restricted, repetitive behaviours or interests (RRBIs)) were explored in 189 children from the Twins Early Development Study, diagnosed with autistic spectrum disorders (ASDs) using the Development and Wellbeing Assessment (DAWBA; Goodman et al. in J Child Psychol Psyc 41:645–655, 2000). A bottom-up approach (analysis 1) used principal component factor analysis of DAWBA items indicating five factors, the first three mapping on the triad. In analysis 2, applying top-down DSM-IV criteria, correlations between domains were modest, strongest between social and communication difficulties. Cross-twin cross-trait correlations suggested small shared genetic effects between RRBIs and other symptoms. These findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-009-0736-1
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789