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Détail de l'auteur
Auteur Angelica RONALD |
Documents disponibles écrits par cet auteur (19)



Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample / Fiona S. MCEWEN in Journal of Child Psychology and Psychiatry, 57-2 (February 2016)
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[article]
Titre : Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample Type de document : Texte imprimé et/ou numérique Auteurs : Fiona S. MCEWEN, Auteur ; Catherine S. STEWART, Auteur ; Emma COLVERT, Auteur ; Emma WOODHOUSE, Auteur ; Sarah CURRAN, Auteur ; Nicola GILLAN, Auteur ; Victoria HALLETT, Auteur ; Stephanie LIETZ, Auteur ; Tracy GARNETT, Auteur ; Angelica RONALD, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur Article en page(s) : p.161-170 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder adolescence assessment diagnosis Index. décimale : PER Périodiques Résumé : Background Increasing numbers of people are being referred for the assessment of autism spectrum disorder (ASD). The NICE (UK) and the American Academy of Pediatrics recommend gathering a developmental history using a tool that operationalises ICD/DSM criteria. However, the best-established diagnostic interview instruments are time consuming, costly and rarely used outside national specialist centres. What is needed is a brief, cost-effective measure validated in community settings. We tested the Development and Well-Being Assessment (DAWBA) for diagnosing ASD in a sample of children/adolescents representative of those presenting in community mental health settings. Methods A general population sample of twins (TEDS) was screened and 276 adolescents were selected as at low (CAST score < 12; n = 164) or high risk for ASD (CAST score ? 15 and/or parent reported that ASD suspected/previously diagnosed; n = 112). Parents completed the ASD module of the DAWBA interview by telephone or online. Families were visited at home: the ADI-R and autism diagnostic observation schedule (ADOS) were completed to allow a best-estimate research diagnosis of ASD to be made. Results Development and Well-Being Assessment ASD symptom scores correlated highly with ADI-R algorithm scores (? = .82, p < .001). Good sensitivity (0.88) and specificity (0.85) were achieved using DAWBA computerised algorithms. Clinician review of responses to DAWBA questions minimally changed sensitivity (0.86) and specificity (0.87). Positive (0.82–0.95) and negative (0.90) predictive values were high. Eighty-six per cent of children were correctly classified. Performance was improved by using it in conjunction with the ADOS. Conclusions The DAWBA is a brief structured interview that showed good sensitivity and specificity in this general population sample. It requires little training, is easy to administer (online or by interview) and diagnosis is aided by an algorithm. It holds promise as a tool for assisting with assessment in community settings and may help services implement the recommendations made by NICE and the American Academy of Pediatrics regarding diagnosis of young people on the autism spectrum. En ligne : http://dx.doi.org/10.1111/jcpp.12447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280
in Journal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.161-170[article] Diagnosing autism spectrum disorder in community settings using the Development and Well-Being Assessment: validation in a UK population-based twin sample [Texte imprimé et/ou numérique] / Fiona S. MCEWEN, Auteur ; Catherine S. STEWART, Auteur ; Emma COLVERT, Auteur ; Emma WOODHOUSE, Auteur ; Sarah CURRAN, Auteur ; Nicola GILLAN, Auteur ; Victoria HALLETT, Auteur ; Stephanie LIETZ, Auteur ; Tracy GARNETT, Auteur ; Angelica RONALD, Auteur ; Declan MURPHY, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur . - p.161-170.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-2 (February 2016) . - p.161-170
Mots-clés : Autism spectrum disorder adolescence assessment diagnosis Index. décimale : PER Périodiques Résumé : Background Increasing numbers of people are being referred for the assessment of autism spectrum disorder (ASD). The NICE (UK) and the American Academy of Pediatrics recommend gathering a developmental history using a tool that operationalises ICD/DSM criteria. However, the best-established diagnostic interview instruments are time consuming, costly and rarely used outside national specialist centres. What is needed is a brief, cost-effective measure validated in community settings. We tested the Development and Well-Being Assessment (DAWBA) for diagnosing ASD in a sample of children/adolescents representative of those presenting in community mental health settings. Methods A general population sample of twins (TEDS) was screened and 276 adolescents were selected as at low (CAST score < 12; n = 164) or high risk for ASD (CAST score ? 15 and/or parent reported that ASD suspected/previously diagnosed; n = 112). Parents completed the ASD module of the DAWBA interview by telephone or online. Families were visited at home: the ADI-R and autism diagnostic observation schedule (ADOS) were completed to allow a best-estimate research diagnosis of ASD to be made. Results Development and Well-Being Assessment ASD symptom scores correlated highly with ADI-R algorithm scores (? = .82, p < .001). Good sensitivity (0.88) and specificity (0.85) were achieved using DAWBA computerised algorithms. Clinician review of responses to DAWBA questions minimally changed sensitivity (0.86) and specificity (0.87). Positive (0.82–0.95) and negative (0.90) predictive values were high. Eighty-six per cent of children were correctly classified. Performance was improved by using it in conjunction with the ADOS. Conclusions The DAWBA is a brief structured interview that showed good sensitivity and specificity in this general population sample. It requires little training, is easy to administer (online or by interview) and diagnosis is aided by an algorithm. It holds promise as a tool for assisting with assessment in community settings and may help services implement the recommendations made by NICE and the American Academy of Pediatrics regarding diagnosis of young people on the autism spectrum. En ligne : http://dx.doi.org/10.1111/jcpp.12447 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 Editorial: Polygenic scores in child and adolescent psychiatry - strengths, weaknesses, opportunities and threats / Angelica RONALD in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)
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Titre : Editorial: Polygenic scores in child and adolescent psychiatry - strengths, weaknesses, opportunities and threats Type de document : Texte imprimé et/ou numérique Auteurs : Angelica RONALD, Auteur Article en page(s) : p.519-521 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Polygenic scores estimate an individual's genetic liability for a particular disorder or trait. They are based on current knowledge of the trait's genetic architecture and focus on common genetic variants. In this editorial, I will discuss some of the strengths, weaknesses, opportunities and threats (SWOT) to polygenic scores within the context of child and adolescent psychiatry. I consider how the potential application of polygenic scores in health settings has some parallels with existing practices, but that polygenic scores also undoubtedly raise unique challenges. This SWOT analysis is accompanied by discussion of some new findings using polygenic scores in this issue of Journal of Child Psychology and Psychiatry. En ligne : http://dx.doi.org/10.1111/jcpp.13246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.519-521[article] Editorial: Polygenic scores in child and adolescent psychiatry - strengths, weaknesses, opportunities and threats [Texte imprimé et/ou numérique] / Angelica RONALD, Auteur . - p.519-521.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.519-521
Index. décimale : PER Périodiques Résumé : Polygenic scores estimate an individual's genetic liability for a particular disorder or trait. They are based on current knowledge of the trait's genetic architecture and focus on common genetic variants. In this editorial, I will discuss some of the strengths, weaknesses, opportunities and threats (SWOT) to polygenic scores within the context of child and adolescent psychiatry. I consider how the potential application of polygenic scores in health settings has some parallels with existing practices, but that polygenic scores also undoubtedly raise unique challenges. This SWOT analysis is accompanied by discussion of some new findings using polygenic scores in this issue of Journal of Child Psychology and Psychiatry. En ligne : http://dx.doi.org/10.1111/jcpp.13246 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 Editorial: Transdiagnostic research: transitory or transformative? / Angelica RONALD in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)
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Editorial: What's in a name? Drawing on the examples of autism and schizophrenia, some reflections on diagnostic labels and their future role in child and adolescent psychiatry / Angelica RONALD in Journal of Child Psychology and Psychiatry, 64-7 (July 2023)
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Titre : Editorial: What's in a name? Drawing on the examples of autism and schizophrenia, some reflections on diagnostic labels and their future role in child and adolescent psychiatry Type de document : Texte imprimé et/ou numérique Auteurs : Angelica RONALD, Auteur Article en page(s) : p.977-979 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Ten years have passed since the release of DSM-5, which brought with it some notable changes in diagnostic labels. In this editorial, the impact of labels, and the changes in labels used in child and adolescent psychiatry, are discussed, with examples drawn from autism and schizophrenia. The diagnostic labels that children and adolescents receive feed into their treatment access and future potential but also to their self-identities. Outside of medicine, extensive budgets and time are spent to test how consumers identify with the labels of products. Diagnoses are not commercial products, of course, but the choice of labels used in child and adolescent psychiatry should remain a priority, in light of their impact on translational science, treatment and on individuals, alongside the ever-evolving nature of language itself. En ligne : https://doi.org/10.1111/jcpp.13839 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.977-979[article] Editorial: What's in a name? Drawing on the examples of autism and schizophrenia, some reflections on diagnostic labels and their future role in child and adolescent psychiatry [Texte imprimé et/ou numérique] / Angelica RONALD, Auteur . - p.977-979.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-7 (July 2023) . - p.977-979
Index. décimale : PER Périodiques Résumé : Ten years have passed since the release of DSM-5, which brought with it some notable changes in diagnostic labels. In this editorial, the impact of labels, and the changes in labels used in child and adolescent psychiatry, are discussed, with examples drawn from autism and schizophrenia. The diagnostic labels that children and adolescents receive feed into their treatment access and future potential but also to their self-identities. Outside of medicine, extensive budgets and time are spent to test how consumers identify with the labels of products. Diagnoses are not commercial products, of course, but the choice of labels used in child and adolescent psychiatry should remain a priority, in light of their impact on translational science, treatment and on individuals, alongside the ever-evolving nature of language itself. En ligne : https://doi.org/10.1111/jcpp.13839 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample / Angelica RONALD in Journal of Child Psychology and Psychiatry, 49-5 (May 2008)
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Titre : Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample Type de document : Texte imprimé et/ou numérique Auteurs : Angelica RONALD, Auteur ; Emily SIMONOFF, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Robert PLOMIN, Auteur Année de publication : 2008 Article en page(s) : p.535–542 Langues : Anglais (eng) Mots-clés : ADD/ADHD autistic-disorder comorbidity genetics twins Index. décimale : PER Périodiques Résumé : Background: High levels of clinical comorbidity have been reported between autistic spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). This study takes an individual differences approach to determine the degree of phenotypic and aetiological overlap between autistic traits and ADHD behaviours in the general population.
Methods: The Twins Early Development Study is a community sample born in England and Wales. Families with twins born in 1994–6 were invited to join; 6,771 families participated in the study when the twins were 8 years old. Parents completed the Childhood Asperger Syndrome Test and the Conners’ DSM-IV subscales. Teacher data were also collected on a sub-sample. High scores on the Conners’ subscales were used to identify possible ADHD cases. Potential ASD cases were interviewed using the Development and Well-Being Assessment. Multivariate structural equation model-fitting was employed, as well as DeFries Fulker extremes analysis and liability threshold model-fitting.
Results: Significant correlations were found between autistic and ADHD traits in the general population (.54 for parent data, .51 for teacher data). In the bivariate models, all genetic correlations were >.50, indicating a moderate degree of overlap in genetic influences on autistic and ADHD traits, both throughout the general population and at the quantitative extreme. This phenotypic and genetic overlap still held when sex, IQ and conduct problems were controlled for, for both parent and teacher data. There was also substantial overlap in suspected cases (41% of children who met criteria for an ASD had suspected ADHD; 22% with suspected ADHD met criteria for an ASD).
Conclusions: These results suggest there are some common genetic influences operating across autistic traits and ADHD behaviours throughout normal variation and at the extreme. This is relevant for molecular genetic research, as well as for psychiatrists and psychologists, who may have assumed these two sets of behaviours are independent.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01857.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386
in Journal of Child Psychology and Psychiatry > 49-5 (May 2008) . - p.535–542[article] Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample [Texte imprimé et/ou numérique] / Angelica RONALD, Auteur ; Emily SIMONOFF, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Robert PLOMIN, Auteur . - 2008 . - p.535–542.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 49-5 (May 2008) . - p.535–542
Mots-clés : ADD/ADHD autistic-disorder comorbidity genetics twins Index. décimale : PER Périodiques Résumé : Background: High levels of clinical comorbidity have been reported between autistic spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). This study takes an individual differences approach to determine the degree of phenotypic and aetiological overlap between autistic traits and ADHD behaviours in the general population.
Methods: The Twins Early Development Study is a community sample born in England and Wales. Families with twins born in 1994–6 were invited to join; 6,771 families participated in the study when the twins were 8 years old. Parents completed the Childhood Asperger Syndrome Test and the Conners’ DSM-IV subscales. Teacher data were also collected on a sub-sample. High scores on the Conners’ subscales were used to identify possible ADHD cases. Potential ASD cases were interviewed using the Development and Well-Being Assessment. Multivariate structural equation model-fitting was employed, as well as DeFries Fulker extremes analysis and liability threshold model-fitting.
Results: Significant correlations were found between autistic and ADHD traits in the general population (.54 for parent data, .51 for teacher data). In the bivariate models, all genetic correlations were >.50, indicating a moderate degree of overlap in genetic influences on autistic and ADHD traits, both throughout the general population and at the quantitative extreme. This phenotypic and genetic overlap still held when sex, IQ and conduct problems were controlled for, for both parent and teacher data. There was also substantial overlap in suspected cases (41% of children who met criteria for an ASD had suspected ADHD; 22% with suspected ADHD met criteria for an ASD).
Conclusions: These results suggest there are some common genetic influences operating across autistic traits and ADHD behaviours throughout normal variation and at the extreme. This is relevant for molecular genetic research, as well as for psychiatrists and psychologists, who may have assumed these two sets of behaviours are independent.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01857.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 Explaining the influence of non-shared environment (NSE) on symptoms of behaviour problems from preschool to adulthood: mind the missing NSE gap / Agnieszka GIDZIELA in Journal of Child Psychology and Psychiatry, 64-5 (May 2023)
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PermalinkExploring anxiety symptoms in a large-scale twin study of children with autism spectrum disorders, their co-twins and controls / Victoria HALLETT in Journal of Child Psychology and Psychiatry, 54-11 (November 2013)
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PermalinkIs quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample / Simone J. CAPP in Journal of Autism and Developmental Disorders, 53-9 (September 2023)
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PermalinkA longitudinal twin study of the association between childhood autistic traits and psychotic experiences in adolescence / Mark J. TAYLOR in Molecular Autism, (July 2015)
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PermalinkA multivariate genetic analysis of anxiety sensitivity, environmental sensitivity and reported life events in adolescents / Alicia J. PEEL in Journal of Child Psychology and Psychiatry, 64-2 (February 2023)
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PermalinkNo major effect of twinning on autistic traits / Sarah CURRAN in Autism Research, 4-5 (October 2011)
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PermalinkPathological demand avoidance: Exploring the behavioural profile / Elizabeth O’NIONS in Autism, 18-5 (July 2014)
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PermalinkPreferential looking to eyes versus mouth in early infancy: heritability and link to concurrent and later development / Charlotte VIKTORSSON in Journal of Child Psychology and Psychiatry, 64-2 (February 2023)
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PermalinkPupil size and pupillary light reflex in early infancy: heritability and link to genetic liability to schizophrenia / Ana Maria PORTUGAL in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)
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PermalinkRelationship between special abilities and autistic-like traits in a large population-based sample of 8-year-olds / Pedro M. VITAL in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)
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