Efficacy of very early interventions on neurodevelopmental outcomes for infants and toddlers at increased likelihood of or diagnosed with autism: A systematic review and meta-analysis / Andrea McGlade in Autism Research, 16-6 (June 2023)  

Public ISBD [article]  inAutism Research > 16-6 (June 2023) . - p.1145-1160 Titre : Efficacy of very early interventions on neurodevelopmental outcomes for infants and toddlers at increased likelihood of or diagnosed with autism: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Andrea McGlade, Auteur ; Koa WHITTINGHAM, Auteur ; Jacqui Barfoot, Auteur ; Leisa Taylor, Auteur ; Roslyn N. BOYD, Auteur Article en page(s) : p.1145-1160 Langues : Anglais (eng) Mots-clés : behavioral intervention  biomarker  developmental psychology  early intervention  infants Index. décimale : PER Périodiques Résumé : Abstract The aim of this systematic review was to determine the efficacy of very early interventions for infants and toddlers at increased likelihood of or diagnosed with autism for autism symptomatology, developmental outcomes and/or neurocognitive markers. Eight databases were searched (14 April 2022) with inclusion criteria: (i) RCTs with care as usual (CAU) comparison group, (ii) participants at increased likelihood of or diagnosed with autism and aged <24?months corrected age (CA), (iii) parent-mediated and/or clinician directed interventions, and (iv) outcome measures were autism symptomatology, cognition, language, adaptive skills, or neurocognitive assessments (EEG and eye tracking). Quality was assessed using Risk of Bias 2 and GRADE. Nineteen publications from 12 studies reported on 715 infants and toddlers. There was low to moderate certainty evidence that clinician-assessed outcomes did not show significant treatment effects for: autism symptomatology (ADOS CSS: MD ?0.08, 95% CI ?0.61, 0.44, p?=?0.75), cognitive outcome (Mullen Scales of Early Learning-Early Learning Composite (MSEL-ELC): SMD 0.05, 95% CI ?0.19, 0.29, p?=?0.67), receptive language (MSEL?Receptive Language: SMD 0.04, 95% CI ?0.21, 0.3, p?=?0.74) or expressive language (MSEL-Expressive Language: SMD 0.06, 95% CI ?0.1, 0.23, p?=?0.45). Neurocognitive outcomes (EEG and eye tracking) were heterogeneous, with inconsistent findings. There is low to moderate certainty evidence that very early interventions have limited impact on neurodevelopmental outcomes by age 3?years. En ligne : https://doi.org/10.1002/aur.2924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 [article] Efficacy of very early interventions on neurodevelopmental outcomes for infants and toddlers at increased likelihood of or diagnosed with autism: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Andrea McGlade, Auteur ; Koa WHITTINGHAM, Auteur ; Jacqui Barfoot, Auteur ; Leisa Taylor, Auteur ; Roslyn N. BOYD, Auteur . - p.1145-1160. Langues : Anglais (eng) in Autism Research > 16-6 (June 2023) . - p.1145-1160 Mots-clés : behavioral intervention  biomarker  developmental psychology  early intervention  infants Index. décimale : PER Périodiques Résumé : Abstract The aim of this systematic review was to determine the efficacy of very early interventions for infants and toddlers at increased likelihood of or diagnosed with autism for autism symptomatology, developmental outcomes and/or neurocognitive markers. Eight databases were searched (14 April 2022) with inclusion criteria: (i) RCTs with care as usual (CAU) comparison group, (ii) participants at increased likelihood of or diagnosed with autism and aged <24?months corrected age (CA), (iii) parent-mediated and/or clinician directed interventions, and (iv) outcome measures were autism symptomatology, cognition, language, adaptive skills, or neurocognitive assessments (EEG and eye tracking). Quality was assessed using Risk of Bias 2 and GRADE. Nineteen publications from 12 studies reported on 715 infants and toddlers. There was low to moderate certainty evidence that clinician-assessed outcomes did not show significant treatment effects for: autism symptomatology (ADOS CSS: MD ?0.08, 95% CI ?0.61, 0.44, p?=?0.75), cognitive outcome (Mullen Scales of Early Learning-Early Learning Composite (MSEL-ELC): SMD 0.05, 95% CI ?0.19, 0.29, p?=?0.67), receptive language (MSEL?Receptive Language: SMD 0.04, 95% CI ?0.21, 0.3, p?=?0.74) or expressive language (MSEL-Expressive Language: SMD 0.06, 95% CI ?0.1, 0.23, p?=?0.45). Neurocognitive outcomes (EEG and eye tracking) were heterogeneous, with inconsistent findings. There is low to moderate certainty evidence that very early interventions have limited impact on neurodevelopmental outcomes by age 3?years. En ligne : https://doi.org/10.1002/aur.2924 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507

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