Age effects on autism heritability and etiological stability of autistic traits / Agnieszka BUTWICKA ; Ebba DU RIETZ ; Aleksandra KANINA ; Mina A. ROSENQVIST ; Henrik LARSSON ; Paul LICHTENSTEIN ; Mark J. TAYLOR in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Titre : Age effects on autism heritability and etiological stability of autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.1135-1144 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Age effects on autism heritability and etiological stability of autistic traits [Texte imprimé et/ou numérique] / Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur . - p.1135-1144. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

A twin study of genetic and environmental contributions to attention-deficit/hyperactivity disorder over time / Mark J. TAYLOR in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1608-1616 Titre : A twin study of genetic and environmental contributions to attention-deficit/hyperactivity disorder over time Type de document : Texte imprimé et/ou numérique Auteurs : Mark J. TAYLOR, Auteur ; Joanna MARTIN, Auteur ; Agnieszka BUTWICKA, Auteur ; Paul LICHTENSTEIN, Auteur ; Brian D'ONOFRIO, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Mina A. ROSENQVIST, Auteur Article en page(s) : p.1608-1616 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) is an increasingly commonly diagnosed neurodevelopmental condition. One possibility is that this reflects a genuine increase in the prevalence of ADHD due to secular environmental changes, yet this hypothesis remains untested. We therefore investigated whether the genetic and environmental variance underlying ADHD, and traits of ADHD, has changed over time. Methods We identified twins born from 1982 to 2008 from the Swedish Twin Registry (STR). We linked the STR with the Swedish National Patient Register and Prescribed Drug Register to identify diagnoses of ADHD and prescriptions of ADHD medication for these twins. We also utilized data collected from participants in the Child and Adolescent Twin Study in Sweden (CATSS), born from 1992 to 2008. Their parents completed a structured ADHD screening tool, which was used to measure traits of ADHD and assign broad screening diagnoses of ADHD. We used the classical twin design to test whether the degree to which variation in these measures was influenced by genetic and environmental variation changed over time. Results We included 22,678 twin pairs from the STR and 15,036 pairs from CATSS. The heritability of ADHD in the STR ranged from 66% to 86% over time, although these fluctuations were not statistically significant. We observed a modest increase in variance in ADHD traits, from 0.98 to 1.09. This was driven by small increases in the underlying genetic and environmental variance, with heritability estimated as 64%-65%. No statistically significant changes in variance in screening diagnoses were observed. Conclusions The relative contribution of genetic and environmental factors to ADHD has remained stable over time, despite its increasing prevalence. Thus, changes in the underlying etiology of ADHD over time are unlikely to explain the increase in ADHD diagnoses. En ligne : https://doi.org/10.1111/jcpp.13854 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] A twin study of genetic and environmental contributions to attention-deficit/hyperactivity disorder over time [Texte imprimé et/ou numérique] / Mark J. TAYLOR, Auteur ; Joanna MARTIN, Auteur ; Agnieszka BUTWICKA, Auteur ; Paul LICHTENSTEIN, Auteur ; Brian D'ONOFRIO, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Mina A. ROSENQVIST, Auteur . - p.1608-1616. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1608-1616 Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) is an increasingly commonly diagnosed neurodevelopmental condition. One possibility is that this reflects a genuine increase in the prevalence of ADHD due to secular environmental changes, yet this hypothesis remains untested. We therefore investigated whether the genetic and environmental variance underlying ADHD, and traits of ADHD, has changed over time. Methods We identified twins born from 1982 to 2008 from the Swedish Twin Registry (STR). We linked the STR with the Swedish National Patient Register and Prescribed Drug Register to identify diagnoses of ADHD and prescriptions of ADHD medication for these twins. We also utilized data collected from participants in the Child and Adolescent Twin Study in Sweden (CATSS), born from 1992 to 2008. Their parents completed a structured ADHD screening tool, which was used to measure traits of ADHD and assign broad screening diagnoses of ADHD. We used the classical twin design to test whether the degree to which variation in these measures was influenced by genetic and environmental variation changed over time. Results We included 22,678 twin pairs from the STR and 15,036 pairs from CATSS. The heritability of ADHD in the STR ranged from 66% to 86% over time, although these fluctuations were not statistically significant. We observed a modest increase in variance in ADHD traits, from 0.98 to 1.09. This was driven by small increases in the underlying genetic and environmental variance, with heritability estimated as 64%-65%. No statistically significant changes in variance in screening diagnoses were observed. Conclusions The relative contribution of genetic and environmental factors to ADHD has remained stable over time, despite its increasing prevalence. Thus, changes in the underlying etiology of ADHD over time are unlikely to explain the increase in ADHD diagnoses. En ligne : https://doi.org/10.1111/jcpp.13854 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

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