Age effects on autism heritability and etiological stability of autistic traits / Agnieszka BUTWICKA ; Ebba DU RIETZ ; Aleksandra KANINA ; Mina A. ROSENQVIST ; Henrik LARSSON ; Paul LICHTENSTEIN ; Mark J. TAYLOR in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Titre : Age effects on autism heritability and etiological stability of autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur Article en page(s) : p.1135-1144 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Age effects on autism heritability and etiological stability of autistic traits [Texte imprimé et/ou numérique] / Agnieszka BUTWICKA, Auteur ; Ebba DU RIETZ, Auteur ; Aleksandra KANINA, Auteur ; Mina A. ROSENQVIST, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mark J. TAYLOR, Auteur . - p.1135-1144. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1135-1144 Index. décimale : PER Périodiques Résumé : Background Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. Methods From 23,849 twin pairs in the Swedish Twin Register born between 1959 and 2010, we identified 485 individuals (1.01%, 31.5% female) with a clinical autism diagnosis. We estimated and compared the relative contribution of genetic, shared, and nonshared environmental influences to autism in childhood and adulthood. We further used multivariate twin analysis with four measurement points among 1,348 twin pairs in the longitudinal Twin Study of Child and Adolescent Development to assess the phenotypic and etiological stability of autistic traits - measured with three scales from the Child Behavior Checklist - from childhood to adulthood. Results Autism heritability was comparable from childhood, (96% [95% CI, 76-99%]) to adulthood (87% [67-96%]). Autistic traits were moderately stable (phenotypic correlation = 0.35-0.61) from childhood to adulthood, and their heritability varied between 52 and 71%. We observed stable as well as newly emerging genetic influences on autistic traits from ages 8-9 to 19-20, and unique nonshared environmental influences at each age. Conclusions Genetic factors are important for autism and autistic traits in adulthood and separate genetic studies in adults are warranted. En ligne : https://doi.org/10.1111/jcpp.13949 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort / Paul LICHTENSTEIN in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.798-806 Titre : Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort Type de document : Texte imprimé et/ou numérique Auteurs : Paul LICHTENSTEIN, Auteur ; Martin CEDERLÖF, Auteur ; Sebastian LUNDSTROM, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik ANCKARSATER, Auteur ; Henrik LARSSON, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.798-806 Langues : Anglais (eng) Mots-clés : Twins  comorbidity  conduct disorder  externalizing disorder  internalizing disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: We examined whether childhood conduct problems predicted a wide range of adverse outcomes in emerging adulthood and whether the association with internalizing problems remained after adjusting for general comorbidity and externalizing problems. METHODS: Participants were 18,649 twins from the Child and Adolescent Twin Study in Sweden. At age 9/12, parents rated their children on eight conduct problems. Adverse outcomes were retrieved from national registers in emerging adulthood (median follow-up time = 9.2 years), including diagnoses of six psychiatric disorders, prescriptions of antidepressants, suicide attempts, criminality, high school ineligibility, and social welfare recipiency. We estimated risk for the separate outcomes and examined if conduct problems predicted an internalizing factor above and beyond a general comorbidity and an externalizing factor. We used twin analyses to estimate genetic and environmental contributions to these associations. RESULTS: On the average, each additional conduct symptom in childhood was associated with a 32% increased risk of the adverse outcomes in emerging adulthood (mean hazard ratio = 1.32; range = 1.16, 1.56). A latent childhood conduct problems factor predicted the internalizing factor in emerging adulthood (?(boys) = .24, standard error, SE = 0.03; ?(girls) = .17, SE = 0.03), above and beyond its association with the externalizing (?(boys) = 0.21, SE = 0.04; ?(girls) = 0.17, SE = 0.05) and general factors (?(boys) = 0.45, SE = 0.03; ?(girls) = 0.34, SE = 0.04). These associations were differentially influenced by genetic and environmental factors. CONCLUSIONS: It is important to monitor boys and girls with conduct problems not only for future externalizing problems, but also for future internalizing problems. Prevention of specific outcomes, however, might require interventions at different levels. En ligne : http://dx.doi.org/10.1111/jcpp.13169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Associations between conduct problems in childhood and adverse outcomes in emerging adulthood: a longitudinal Swedish nationwide twin cohort [Texte imprimé et/ou numérique] / Paul LICHTENSTEIN, Auteur ; Martin CEDERLÖF, Auteur ; Sebastian LUNDSTROM, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik ANCKARSATER, Auteur ; Henrik LARSSON, Auteur ; Erik PETTERSSON, Auteur . - p.798-806. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-7 (July 2020) . - p.798-806 Mots-clés : Twins  comorbidity  conduct disorder  externalizing disorder  internalizing disorder Index. décimale : PER Périodiques Résumé : BACKGROUND: We examined whether childhood conduct problems predicted a wide range of adverse outcomes in emerging adulthood and whether the association with internalizing problems remained after adjusting for general comorbidity and externalizing problems. METHODS: Participants were 18,649 twins from the Child and Adolescent Twin Study in Sweden. At age 9/12, parents rated their children on eight conduct problems. Adverse outcomes were retrieved from national registers in emerging adulthood (median follow-up time = 9.2 years), including diagnoses of six psychiatric disorders, prescriptions of antidepressants, suicide attempts, criminality, high school ineligibility, and social welfare recipiency. We estimated risk for the separate outcomes and examined if conduct problems predicted an internalizing factor above and beyond a general comorbidity and an externalizing factor. We used twin analyses to estimate genetic and environmental contributions to these associations. RESULTS: On the average, each additional conduct symptom in childhood was associated with a 32% increased risk of the adverse outcomes in emerging adulthood (mean hazard ratio = 1.32; range = 1.16, 1.56). A latent childhood conduct problems factor predicted the internalizing factor in emerging adulthood (?(boys) = .24, standard error, SE = 0.03; ?(girls) = .17, SE = 0.03), above and beyond its association with the externalizing (?(boys) = 0.21, SE = 0.04; ?(girls) = 0.17, SE = 0.05) and general factors (?(boys) = 0.45, SE = 0.03; ?(girls) = 0.34, SE = 0.04). These associations were differentially influenced by genetic and environmental factors. CONCLUSIONS: It is important to monitor boys and girls with conduct problems not only for future externalizing problems, but also for future internalizing problems. Prevention of specific outcomes, however, might require interventions at different levels. En ligne : http://dx.doi.org/10.1111/jcpp.13169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs / Cen CHEN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522 Titre : Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs Type de document : Texte imprimé et/ou numérique Auteurs : Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.1513-1522 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Twins, Dizygotic  Longitudinal Studies  Psychopathology  Mental Disorders/epidemiology/genetics  Risk Factors  Attention Deficit Disorder with Hyperactivity/epidemiology  General factor of psychopathology  genetic nurture  multi-polygenic score  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (Î2) and then within DZ twin pairs (Î2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (Î2=0.09, 95% CI: [0.06, 0.12]; Î2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (Î2=0.04 [0.00, 0.08]; Î2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (Î2=0.07 [0.04, 0.11]; Î2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (Î2=0.08 [0.03, 0.13]; Î2(w) =0.19 [0.08, 0.30]) and specific inattention problems (Î2=0.05 [0.01, 0.09]; Î2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (Î2=0.06 [0.02, 0.10]; Î2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs [Texte imprimé et/ou numérique] / Cen CHEN, Auteur ; Yi LU, Auteur ; Sebastian LUNDSTROM, Auteur ; Henrik LARSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Erik PETTERSSON, Auteur . - p.1513-1522. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1513-1522 Mots-clés : Adolescent  Humans  Twins, Dizygotic  Longitudinal Studies  Psychopathology  Mental Disorders/epidemiology/genetics  Risk Factors  Attention Deficit Disorder with Hyperactivity/epidemiology  General factor of psychopathology  genetic nurture  multi-polygenic score  polygenic risk scores Index. décimale : PER Périodiques Résumé : BACKGROUND: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS-psychiatric symptom associations were attributable to indirect versus direct pathways. METHODS: The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence (n=2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (Î2) and then within DZ twin pairs (Î2(w) ), which controls for indirect pathways. RESULTS: In childhood, the PRS for ADHD predicted general psychopathology (Î2=0.09, 95% CI: [0.06, 0.12]; Î2(w) =0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (Î2=0.04 [0.00, 0.08]; Î2(w) =0.09 [0.01, 0.17]) and specific hyperactivity (Î2=0.07 [0.04, 0.11]; Î2(w) =0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (Î2=0.08 [0.03, 0.13]; Î2(w) =0.19 [0.08, 0.30]) and specific inattention problems (Î2=0.05 [0.01, 0.09]; Î2(w) =0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (Î2=0.06 [0.02, 0.10]; Î2(w) =0.06 [0.00, 0.12]). Overall, the PRS-general factor associations were similar between individuals and within twin pairs, whereas the PRS-specific factors associations amplified by 84% within pairs. CONCLUSIONS: This implies that PRS-psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology. En ligne : http://dx.doi.org/10.1111/jcpp.13605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Birth weight as an independent predictor of ADHD symptoms: a within-twin pair analysis / Erik PETTERSSON in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.453-459 Titre : Birth weight as an independent predictor of ADHD symptoms: a within-twin pair analysis Type de document : Texte imprimé et/ou numérique Auteurs : Erik PETTERSSON, Auteur ; Arvid SJÖLANDER, Auteur ; Catarina ALMQVIST, Auteur ; Henrik ANCKARSATER, Auteur ; Brian M. D'ONOFRIO, Auteur ; Paul LICHTENSTEIN, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.453-459 Langues : Anglais (eng) Mots-clés : ADHD  DSM  birth weight  behavioral genetics  environmental influences Index. décimale : PER Périodiques Résumé : Background Studies have found an association between low birth weight and ADHD, but the nature of this relation is unclear. First, it is uncertain whether birth weight is associated with both of the ADHD dimensions, inattentiveness and hyperactivity-impulsivity. Second, it remains uncertain whether the association between birth weight and ADHD symptom severity is confounded by familial factors. Method Parents of all Swedish 9- and 12-year-old twins born between 1992 and 2000 were interviewed for DSM-IV inattentive and hyperactive-impulsive ADHD symptoms by the Autism – Tics, AD/HD and other Comorbidities (A-TAC) inventory (N = 21,775 twins). Birth weight was collected prospectively through the Medical Birth Registry. We used a within-twin pair design to control for genetic and shared environmental factors. Results Reduced birth weight was significantly associated with a mean increase in total ADHD (? = ?.42; 95% CI: ?.53, ?.30), inattentive (? = ?.26; 95% CI: ?.33, ?.19), and hyperactive-impulsive (? = ?.16; 95% CI: ?.22, ?.10) symptom severity. These results imply that a change of one kilogram of birth weight corresponded to parents rating their child nearly one unit higher (going from “no” to “yes, to some extent” on a given symptom) on the total ADHD scale. These associations remained within pairs of MZ and DZ twins, and were also present when restricting the analyses to full term births. Conclusions There is an independent association between low birth weight and all forms of ADHD symptoms, even after controlling for all environmental and genetic confounds shared within twin pairs. These results indicate that fetal growth restriction (as reflected in birth weight differences within twin pairs) and/or the environmental factors which influence it is in the casual pathway leading to ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12299 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Birth weight as an independent predictor of ADHD symptoms: a within-twin pair analysis [Texte imprimé et/ou numérique] / Erik PETTERSSON, Auteur ; Arvid SJÖLANDER, Auteur ; Catarina ALMQVIST, Auteur ; Henrik ANCKARSATER, Auteur ; Brian M. D'ONOFRIO, Auteur ; Paul LICHTENSTEIN, Auteur ; Henrik LARSSON, Auteur . - p.453-459. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.453-459 Mots-clés : ADHD  DSM  birth weight  behavioral genetics  environmental influences Index. décimale : PER Périodiques Résumé : Background Studies have found an association between low birth weight and ADHD, but the nature of this relation is unclear. First, it is uncertain whether birth weight is associated with both of the ADHD dimensions, inattentiveness and hyperactivity-impulsivity. Second, it remains uncertain whether the association between birth weight and ADHD symptom severity is confounded by familial factors. Method Parents of all Swedish 9- and 12-year-old twins born between 1992 and 2000 were interviewed for DSM-IV inattentive and hyperactive-impulsive ADHD symptoms by the Autism – Tics, AD/HD and other Comorbidities (A-TAC) inventory (N = 21,775 twins). Birth weight was collected prospectively through the Medical Birth Registry. We used a within-twin pair design to control for genetic and shared environmental factors. Results Reduced birth weight was significantly associated with a mean increase in total ADHD (? = ?.42; 95% CI: ?.53, ?.30), inattentive (? = ?.26; 95% CI: ?.33, ?.19), and hyperactive-impulsive (? = ?.16; 95% CI: ?.22, ?.10) symptom severity. These results imply that a change of one kilogram of birth weight corresponded to parents rating their child nearly one unit higher (going from “no” to “yes, to some extent” on a given symptom) on the total ADHD scale. These associations remained within pairs of MZ and DZ twins, and were also present when restricting the analyses to full term births. Conclusions There is an independent association between low birth weight and all forms of ADHD symptoms, even after controlling for all environmental and genetic confounds shared within twin pairs. These results indicate that fetal growth restriction (as reflected in birth weight differences within twin pairs) and/or the environmental factors which influence it is in the casual pathway leading to ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12299 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Childhood and adolescence outcomes in offspring to parents with bipolar disorder: the impact of lifetime parental comorbidity, parental sex, and bipolar subtype / Mengping ZHOU ; Marcus BOMAN ; Arvid SJÖLANDER ; Henrik LARSSON ; Brian M. D'ONOFRIO ; Erik PETTERSSON ; Paul LICHTENSTEIN ; Mikael LANDÉN in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1355-1368 Titre : Childhood and adolescence outcomes in offspring to parents with bipolar disorder: the impact of lifetime parental comorbidity, parental sex, and bipolar subtype Type de document : Texte imprimé et/ou numérique Auteurs : Mengping ZHOU, Auteur ; Marcus BOMAN, Auteur ; Arvid SJÖLANDER, Auteur ; Henrik LARSSON, Auteur ; Brian M. D'ONOFRIO, Auteur ; Erik PETTERSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mikael LANDÉN, Auteur Article en page(s) : p.1355-1368 Langues : Anglais (eng) Mots-clés : Bipolar disorder  adolescence  epidemiology  suicidal behavior  parent-child relationships Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder have increased risks of their own psychopathology. However, a large-scale survey of psychiatric, somatic, and adverse social outcomes up to adulthood, which could aid in prioritizing and tailoring prevention, is lacking. It also remains to clarify how risks are modified by other parental factors. Methods Swedish population registers were linked to compare offspring having (N?=?24,788) and not having (N?=?247,880) a parent with bipolar disorder with respect to psychiatric diagnoses and psychotropic medication, birth-related and somatic conditions, social outcomes, accidents, suicide attempts, and mortality. Individuals were followed until age 18. We estimated the influence of lifetime parental psychiatric comorbidity, bipolar disorder subtype, and sex on outcomes. Results Children of parents with bipolar disorder had 2?3 times higher risks of all psychiatric diagnoses, except for bipolar disorder, for which the risk was 11-fold. Significantly increased risks were also found for several somatic conditions, low school grades, criminal behavior, victimization, accidents, and suicidal behavior. Adjusting for lifetime parental psychiatric comorbidity attenuated most associations. Offspring of a parent with bipolar disorder type 2 had statistically significantly higher risks of attention deficit hyperactivity disorder, respiratory tract conditions, and accidents compared with offspring of a parent with bipolar disorder type 1. Offspring of mothers with bipolar disorder had higher risks of several psychiatric diagnoses, respiratory tract conditions, low school grades, and accidents compared with offspring of fathers with bipolar disorder. Having two parents with bipolar disorder entailed the highest risks of psychiatric outcomes in offspring. Conclusions Early intervention and family support are particularly warranted for the offspring of a parent with bipolar disorder in the presence of lifetime parental psychiatric comorbidity, when the parent has bipolar disorder type 2, or when the mother or both parents have bipolar disorder. En ligne : https://doi.org/10.1111/jcpp.13982 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Childhood and adolescence outcomes in offspring to parents with bipolar disorder: the impact of lifetime parental comorbidity, parental sex, and bipolar subtype [Texte imprimé et/ou numérique] / Mengping ZHOU, Auteur ; Marcus BOMAN, Auteur ; Arvid SJÖLANDER, Auteur ; Henrik LARSSON, Auteur ; Brian M. D'ONOFRIO, Auteur ; Erik PETTERSSON, Auteur ; Paul LICHTENSTEIN, Auteur ; Mikael LANDÉN, Auteur . - p.1355-1368. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1355-1368 Mots-clés : Bipolar disorder  adolescence  epidemiology  suicidal behavior  parent-child relationships Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder have increased risks of their own psychopathology. However, a large-scale survey of psychiatric, somatic, and adverse social outcomes up to adulthood, which could aid in prioritizing and tailoring prevention, is lacking. It also remains to clarify how risks are modified by other parental factors. Methods Swedish population registers were linked to compare offspring having (N?=?24,788) and not having (N?=?247,880) a parent with bipolar disorder with respect to psychiatric diagnoses and psychotropic medication, birth-related and somatic conditions, social outcomes, accidents, suicide attempts, and mortality. Individuals were followed until age 18. We estimated the influence of lifetime parental psychiatric comorbidity, bipolar disorder subtype, and sex on outcomes. Results Children of parents with bipolar disorder had 2?3 times higher risks of all psychiatric diagnoses, except for bipolar disorder, for which the risk was 11-fold. Significantly increased risks were also found for several somatic conditions, low school grades, criminal behavior, victimization, accidents, and suicidal behavior. Adjusting for lifetime parental psychiatric comorbidity attenuated most associations. Offspring of a parent with bipolar disorder type 2 had statistically significantly higher risks of attention deficit hyperactivity disorder, respiratory tract conditions, and accidents compared with offspring of a parent with bipolar disorder type 1. Offspring of mothers with bipolar disorder had higher risks of several psychiatric diagnoses, respiratory tract conditions, low school grades, and accidents compared with offspring of fathers with bipolar disorder. Having two parents with bipolar disorder entailed the highest risks of psychiatric outcomes in offspring. Conclusions Early intervention and family support are particularly warranted for the offspring of a parent with bipolar disorder in the presence of lifetime parental psychiatric comorbidity, when the parent has bipolar disorder type 2, or when the mother or both parents have bipolar disorder. En ligne : https://doi.org/10.1111/jcpp.13982 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 53-1 (January 2012)  

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Childhood Neurodevelopmental Disorders and Violent Criminality: A Sibling Control Study / Sebastian LUNDSTROM in Journal of Autism and Developmental Disorders, 44-11 (November 2014)  

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Codevelopment of ADHD and externalizing behavior from childhood to adulthood / Ralf KUJA-HALKOLA in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

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Commentary: How can family-based quasi-experimental designs and national registers be used to address confounding in risk factor studies of psychopathology? A reflection on Obel et al. (2016) / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

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Commentary: Important design features to consider in observational research on the long-term outcomes of ADHD – reflections on Sibley et al. (2017) and Swanson et al. (2017) / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 58-6 (June 2017)  

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Commentary: Psychopathic traits enhance adolescents’ influence on others and make them less easily influenced by others? – reflections on Kerr et al. (2012) / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)  

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Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology / Henrik LARSSON in Journal of Child Psychology and Psychiatry, 52-9 (September 2011)  

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Examining protective factors for substance use problems and self-harm behavior during adolescence: A longitudinal co-twin control study / Lauren O’REILLY in Development and Psychopathology, 34-5 (December 2022)  

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Familial aggregation of attention-deficit/hyperactivity disorder / Qi CHEN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

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Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring / Charlotte SKOGLUND in Journal of Child Psychology and Psychiatry, 55-1 (January 2014)  

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