Increased alpha power in autistic adults: Relation to sensory behaviors and cortical volume / Scott O. MURRAY ; Daniela L. SECZON ; Mark PETTET ; Hannah M. REA ; Kristin M. WOODARD ; Tamar KOLODNY ; Sara Jane WEBB in Autism Research, 18-1 (January 2025)  

Public ISBD [article]  inAutism Research > 18-1 (January 2025) . - p.56-69 Titre : Increased alpha power in autistic adults: Relation to sensory behaviors and cortical volume : Autism Research Type de document : texte imprimé Auteurs : Scott O. MURRAY, Auteur ; Daniela L. SECZON, Auteur ; Mark PETTET, Auteur ; Hannah M. REA, Auteur ; Kristin M. WOODARD, Auteur ; Tamar KOLODNY, Auteur ; Sara Jane WEBB, Auteur Article en page(s) : p.56-69 Langues : Anglais (eng) Mots-clés : alpha  autism spectrum disorder  EEG  sensory processing  vision Index. décimale : PER Périodiques Résumé : Abstract Alpha-band (~10 Hz) neural oscillations, crucial for gating sensory information, may offer insights into the atypical sensory experiences characteristic of autism spectrum disorder (ASD). We investigated alpha-band EEG activity in autistic adults (n 29) compared with a nonautistic group (n 23) under various stimulus-driven and resting-state conditions. The autistic group showed consistently higher alpha amplitude across all time points. In addition, there was proportionally more suppression of alpha at stimulus onset in the autistic group, and alpha amplitude in this stimulus-onset period correlated with sensory behaviors. Recent research suggests a link between subcortical structures' volume and cortical alpha magnitude. Prompted by this, we explored the association between alpha power and the volume of subcortical structures and total cortical volume in ASD. Our findings indicate a significant correlation with total cortical volume and a group by hippocampal volume interaction, pointing to the potential role of anatomical structural characteristics as potential modulators of cortical alpha oscillations in ASD. Overall, the results highlight altered alpha in autistic individuals as potentially contributing to the heightened sensory symptoms in autistic compared with nonautistic adults. En ligne : https://doi.org/10.1002/aur.3266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Increased alpha power in autistic adults: Relation to sensory behaviors and cortical volume : Autism Research [texte imprimé] / Scott O. MURRAY, Auteur ; Daniela L. SECZON, Auteur ; Mark PETTET, Auteur ; Hannah M. REA, Auteur ; Kristin M. WOODARD, Auteur ; Tamar KOLODNY, Auteur ; Sara Jane WEBB, Auteur . - p.56-69. Langues : Anglais (eng) in Autism Research > 18-1 (January 2025) . - p.56-69 Mots-clés : alpha  autism spectrum disorder  EEG  sensory processing  vision Index. décimale : PER Périodiques Résumé : Abstract Alpha-band (~10 Hz) neural oscillations, crucial for gating sensory information, may offer insights into the atypical sensory experiences characteristic of autism spectrum disorder (ASD). We investigated alpha-band EEG activity in autistic adults (n 29) compared with a nonautistic group (n 23) under various stimulus-driven and resting-state conditions. The autistic group showed consistently higher alpha amplitude across all time points. In addition, there was proportionally more suppression of alpha at stimulus onset in the autistic group, and alpha amplitude in this stimulus-onset period correlated with sensory behaviors. Recent research suggests a link between subcortical structures' volume and cortical alpha magnitude. Prompted by this, we explored the association between alpha power and the volume of subcortical structures and total cortical volume in ASD. Our findings indicate a significant correlation with total cortical volume and a group by hippocampal volume interaction, pointing to the potential role of anatomical structural characteristics as potential modulators of cortical alpha oscillations in ASD. Overall, the results highlight altered alpha in autistic individuals as potentially contributing to the heightened sensory symptoms in autistic compared with nonautistic adults. En ligne : https://doi.org/10.1002/aur.3266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Rhythmic attentional sampling in autism / Tamar KOLODNY ; Kristin M. WOODARD ; Aydin TASEVAC ; Wesley R. GANZ ; Hannah M. REA ; Evangeline C. KURTZ-NELSON ; Sara Jane WEBB ; Scott O. MURRAY in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2090-2099 Titre : Rhythmic attentional sampling in autism Type de document : texte imprimé Auteurs : Tamar KOLODNY, Auteur ; Kristin M. WOODARD, Auteur ; Aydin TASEVAC, Auteur ; Wesley R. GANZ, Auteur ; Hannah M. REA, Auteur ; Evangeline C. KURTZ-NELSON, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur Article en page(s) : p.2090-2099 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism often display alterations in visual spatial attention toward visual stimuli, but the underlying cause of these differences remains unclear. Recent evidence has demonstrated that covert spatial attention, rather than remaining constant at a cued location, samples stimuli rhythmically at a frequency of 4-8 Hz (theta). Here we tested whether rhythmic sampling of attention is altered in autism. Participants were asked to monitor three locations to detect a brief target presented 300-1200 ms after a spatial cue. Visual attention was oriented to the cue and modified visual processing at the cued location, consistent with previous studies. We measured detection performance at different cue-target intervals when the target occurred at the cued location. Significant oscillations in detection performance were identified using both a traditional time-shuffled approach and a new autoregressive surrogate method developed by Brookshire in 2022. We found that attention enhances behavioral performance rhythmically at the same frequency in both autism and control group at the cued location. However, rhythmic temporal structure was not observed in a subgroup of autistic individuals with co-occurring attention-deficit/hyperactivity disorder (ADHD). Our results imply that intrinsic brain rhythms which organize neural activity into alternating attentional states is functional in autistic individuals, but may be altered in autistic participants who have a concurrent ADHD diagnosis. En ligne : https://doi.org/10.1002/aur.3021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Rhythmic attentional sampling in autism [texte imprimé] / Tamar KOLODNY, Auteur ; Kristin M. WOODARD, Auteur ; Aydin TASEVAC, Auteur ; Wesley R. GANZ, Auteur ; Hannah M. REA, Auteur ; Evangeline C. KURTZ-NELSON, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur . - p.2090-2099. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2090-2099 Index. décimale : PER Périodiques Résumé : Abstract Individuals diagnosed with autism often display alterations in visual spatial attention toward visual stimuli, but the underlying cause of these differences remains unclear. Recent evidence has demonstrated that covert spatial attention, rather than remaining constant at a cued location, samples stimuli rhythmically at a frequency of 4-8 Hz (theta). Here we tested whether rhythmic sampling of attention is altered in autism. Participants were asked to monitor three locations to detect a brief target presented 300-1200 ms after a spatial cue. Visual attention was oriented to the cue and modified visual processing at the cued location, consistent with previous studies. We measured detection performance at different cue-target intervals when the target occurred at the cued location. Significant oscillations in detection performance were identified using both a traditional time-shuffled approach and a new autoregressive surrogate method developed by Brookshire in 2022. We found that attention enhances behavioral performance rhythmically at the same frequency in both autism and control group at the cued location. However, rhythmic temporal structure was not observed in a subgroup of autistic individuals with co-occurring attention-deficit/hyperactivity disorder (ADHD). Our results imply that intrinsic brain rhythms which organize neural activity into alternating attentional states is functional in autistic individuals, but may be altered in autistic participants who have a concurrent ADHD diagnosis. En ligne : https://doi.org/10.1002/aur.3021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG / Daniela L. SECZON in Autism Research, 19-9 (September 2026)  

Public ISBD [article]  inAutism Research > 19-9 (September 2026) . - p. e70335 Titre : Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG Type de document : texte imprimé Auteurs : Daniela L. SECZON, Auteur ; Kristin M. WOODARD, Auteur ; Tamar KOLODNY, Auteur ; Hannah M. REA, Auteur ; Mark PETTET, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur Article en page(s) : p. e70335 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals frequently report heightened sensitivity to visual stimuli, often described as discomfort in environments with bright or flickering lights. These experiences are hypothesized to reflect underlying differences in sensory gain or neural hyperexcitability; however, findings across studies have yielded mixed results, likely due to methodological variability. This study aimed to evaluate whether group differences in contrast-dependent neural and behavioral responses to a visual stimulus would be observed across complementary methods: psychophysics, fMRI, and EEG. Thirty-one autistic and twenty-seven non-autistic adults completed experimental sessions in which they passively viewed bilaterally presented 6?Hz counterphase flickering checkerboards at high (100%) and low (2%) contrast. Neural responses were measured using the blood oxygenation level-dependent (BOLD) signal from fMRI and steady-state visual evoked potential (SSVEP) from EEG. Contrast robustly modulated responses across experiments, eliciting higher neural responses; however, no group differences emerged in BOLD or behavioral thresholds. The only significant group difference was observed in SSVEP amplitudes, with autistic individuals showing significantly higher neural entrainment to the flickering stimulus than their non-autistic counterparts. Moreover, SSVEP amplitudes were associated with BOLD responses to the same low contrast visual stimulus, suggesting convergence between frequency-locked EEG responses and hemodynamic activity. SSVEP amplitudes were additionally associated with self-reported measures of hypersensitivity, linking heightened neural entrainment to individual differences in sensory experiences. They also showed a differential relationship with perceptual thresholds across groups. These findings show that differences between autistic and non-autistic participants were more evident in frequency-locked neural responses to periodic visual input, as measured by SSVEPs, and that these responses were meaningfully related to visual cortical BOLD activity and sensory hypersensitivity. En ligne : https://doi.org/10.1002/aur.70335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG [texte imprimé] / Daniela L. SECZON, Auteur ; Kristin M. WOODARD, Auteur ; Tamar KOLODNY, Auteur ; Hannah M. REA, Auteur ; Mark PETTET, Auteur ; Sara Jane WEBB, Auteur ; Scott O. MURRAY, Auteur . - p. e70335. Langues : Anglais (eng) in Autism Research > 19-9 (September 2026) . - p. e70335 Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic individuals frequently report heightened sensitivity to visual stimuli, often described as discomfort in environments with bright or flickering lights. These experiences are hypothesized to reflect underlying differences in sensory gain or neural hyperexcitability; however, findings across studies have yielded mixed results, likely due to methodological variability. This study aimed to evaluate whether group differences in contrast-dependent neural and behavioral responses to a visual stimulus would be observed across complementary methods: psychophysics, fMRI, and EEG. Thirty-one autistic and twenty-seven non-autistic adults completed experimental sessions in which they passively viewed bilaterally presented 6?Hz counterphase flickering checkerboards at high (100%) and low (2%) contrast. Neural responses were measured using the blood oxygenation level-dependent (BOLD) signal from fMRI and steady-state visual evoked potential (SSVEP) from EEG. Contrast robustly modulated responses across experiments, eliciting higher neural responses; however, no group differences emerged in BOLD or behavioral thresholds. The only significant group difference was observed in SSVEP amplitudes, with autistic individuals showing significantly higher neural entrainment to the flickering stimulus than their non-autistic counterparts. Moreover, SSVEP amplitudes were associated with BOLD responses to the same low contrast visual stimulus, suggesting convergence between frequency-locked EEG responses and hemodynamic activity. SSVEP amplitudes were additionally associated with self-reported measures of hypersensitivity, linking heightened neural entrainment to individual differences in sensory experiences. They also showed a differential relationship with perceptual thresholds across groups. These findings show that differences between autistic and non-autistic participants were more evident in frequency-locked neural responses to periodic visual input, as measured by SSVEPs, and that these responses were meaningfully related to visual cortical BOLD activity and sensory hypersensitivity. En ligne : https://doi.org/10.1002/aur.70335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

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