The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study / Kazuki MATSUMOTO ; Fumio OSONE ; Akira HARA ; Siqing GUAN ; Sayo HAMATANI ; Katsumasa MUNEOKA ; Koichi SATO ; Akihiro OKADA ; Tokuzou YOKOKAWA in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.193-210 Titre : The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study Type de document : Texte imprimé et/ou numérique Auteurs : Kazuki MATSUMOTO, Auteur ; Fumio OSONE, Auteur ; Akira HARA, Auteur ; Siqing GUAN, Auteur ; Sayo HAMATANI, Auteur ; Katsumasa MUNEOKA, Auteur ; Koichi SATO, Auteur ; Akihiro OKADA, Auteur ; Tokuzou YOKOKAWA, Auteur Article en page(s) : p.193-210 Index. décimale : PER Périodiques Résumé : Proton magnetic resonance spectroscopy (1H-MRS) has shown inconsistent alterations in brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain metabolites in the medial prefrontal cortex and amygdala of 24 drug-naive adults with ASD and no intellectual disability and 24 non-ASD control subjects, using 3 T 1H-MRS. Adults with ASD showed no significant differences from control in glutamate, glutamate plus glutamine, N-acetylaspartate, glycerophosphorylcholine plus phosphorylcholine, creatine plus phosphocreatine, or myo-inositol in either region. However, ASD subjects did show significant correlations of localized brain metabolites with autistic traits, empathy deficits, and personality traits using the Autism-Spectrum Quotient, Questionnaire of Cognitive and Affective Empathy, Interpersonal Reactivity Index, and NEO Personality Inventory-Revised. These findings should be taken as preliminary or exploratory. En ligne : https://doi.org/10.1007/s10803-022-05778-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study [Texte imprimé et/ou numérique] / Kazuki MATSUMOTO, Auteur ; Fumio OSONE, Auteur ; Akira HARA, Auteur ; Siqing GUAN, Auteur ; Sayo HAMATANI, Auteur ; Katsumasa MUNEOKA, Auteur ; Koichi SATO, Auteur ; Akihiro OKADA, Auteur ; Tokuzou YOKOKAWA, Auteur . - p.193-210. in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.193-210 Index. décimale : PER Périodiques Résumé : Proton magnetic resonance spectroscopy (1H-MRS) has shown inconsistent alterations in brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain metabolites in the medial prefrontal cortex and amygdala of 24 drug-naive adults with ASD and no intellectual disability and 24 non-ASD control subjects, using 3 T 1H-MRS. Adults with ASD showed no significant differences from control in glutamate, glutamate plus glutamine, N-acetylaspartate, glycerophosphorylcholine plus phosphorylcholine, creatine plus phosphocreatine, or myo-inositol in either region. However, ASD subjects did show significant correlations of localized brain metabolites with autistic traits, empathy deficits, and personality traits using the Autism-Spectrum Quotient, Questionnaire of Cognitive and Affective Empathy, Interpersonal Reactivity Index, and NEO Personality Inventory-Revised. These findings should be taken as preliminary or exploratory. En ligne : https://doi.org/10.1007/s10803-022-05778-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

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