Early pyridoxine administration rescues autism-like behavior in the BTBR T+tf/J autistic model / Wenyu SHAO ; Yichun SU ; Jiayin LIU ; Jing LUO ; Yi LUO ; Lian WANG ; Xiaotang FAN in Research in Autism Spectrum Disorders, 115 (July 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 115 (July 2024) . - p.102410 Titre : Early pyridoxine administration rescues autism-like behavior in the BTBR T+tf/J autistic model Type de document : Texte imprimé et/ou numérique Auteurs : Wenyu SHAO, Auteur ; Yichun SU, Auteur ; Jiayin LIU, Auteur ; Jing LUO, Auteur ; Yi LUO, Auteur ; Lian WANG, Auteur ; Xiaotang FAN, Auteur Article en page(s) : p.102410 Langues : Anglais (eng) Mots-clés : Autism  Pyridoxine  Neuroinflammation  Oxidative stress  Sociability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social impairment and repetitive, stereotyped behaviors. An imbalanced oxidative stress status and neuroinflammation are involved in ASD development. In this study, we investigated the effects of pyridoxine, a form of vitamin B6 with potent anti-oxidant and anti-inflammatory features, on autism-like behavior in BTBR T + ltpr3tf/J (BTBR) mice, a model of autism. Mice received pyridoxine from postnatal days 7 to 14. Behavioral tests were conducted on 8-week-old male mice, and the inflammatory status and oxidative stress levels were also assessed in the mouse hippocampus. Postnatal pyridoxine treatment significantly improved social deficits, stereotyped behaviors, and cognitive deficits in BTBR mice. In addition, pyridoxine treatment alleviated neuroinflammation in the hippocampus manifested by reduced Iba1+ microglia and inflammatory factors, such as interleukin-1? (IL-1?), IL-6, TNF-?, and NF-?B. Further, pyridoxine-treated BTBR mice had elevated Nrf2 and HO-1 in the hippocampus. Postnatal pyridoxine administration might improve autistic-like behaviors in BTBR mice via attenuating oxidative stress and neuroinflammation in the hippocampus. En ligne : https://doi.org/10.1016/j.rasd.2024.102410 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Early pyridoxine administration rescues autism-like behavior in the BTBR T+tf/J autistic model [Texte imprimé et/ou numérique] / Wenyu SHAO, Auteur ; Yichun SU, Auteur ; Jiayin LIU, Auteur ; Jing LUO, Auteur ; Yi LUO, Auteur ; Lian WANG, Auteur ; Xiaotang FAN, Auteur . - p.102410. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 115 (July 2024) . - p.102410 Mots-clés : Autism  Pyridoxine  Neuroinflammation  Oxidative stress  Sociability Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social impairment and repetitive, stereotyped behaviors. An imbalanced oxidative stress status and neuroinflammation are involved in ASD development. In this study, we investigated the effects of pyridoxine, a form of vitamin B6 with potent anti-oxidant and anti-inflammatory features, on autism-like behavior in BTBR T + ltpr3tf/J (BTBR) mice, a model of autism. Mice received pyridoxine from postnatal days 7 to 14. Behavioral tests were conducted on 8-week-old male mice, and the inflammatory status and oxidative stress levels were also assessed in the mouse hippocampus. Postnatal pyridoxine treatment significantly improved social deficits, stereotyped behaviors, and cognitive deficits in BTBR mice. In addition, pyridoxine treatment alleviated neuroinflammation in the hippocampus manifested by reduced Iba1+ microglia and inflammatory factors, such as interleukin-1? (IL-1?), IL-6, TNF-?, and NF-?B. Further, pyridoxine-treated BTBR mice had elevated Nrf2 and HO-1 in the hippocampus. Postnatal pyridoxine administration might improve autistic-like behaviors in BTBR mice via attenuating oxidative stress and neuroinflammation in the hippocampus. En ligne : https://doi.org/10.1016/j.rasd.2024.102410 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

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