Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia / Katherine H. KARLSGODT in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1297-1327 Titre : Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Daqiang SUN, Auteur ; Amy M. JIMENEZ, Auteur ; Evan S. LUTKENHOFF, Auteur ; Rachael WILLHITE, Auteur ; Theo G. M. VAN ERP, Auteur Année de publication : 2008 Article en page(s) : p.1297-1327 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Schizophrenia has been thought of as a disorder of reduced functional and structural connectivity. Recent advances in neuroimaging techniques such as functional magnetic resonance imaging, structural magnetic resonance imaging, diffusion tensor imaging, and small animal imaging have advanced our ability to investigate this hypothesis. Moreover, the power of longitudinal designs possible with these noninvasive techniques enable the study of not just how connectivity is disrupted in schizophrenia, but when this disruption emerges during development. This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder. We conclude that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity. En ligne : http://dx.doi.org/10.1017/s095457940800062x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603 [article] Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia [Texte imprimé et/ou numérique] / Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Daqiang SUN, Auteur ; Amy M. JIMENEZ, Auteur ; Evan S. LUTKENHOFF, Auteur ; Rachael WILLHITE, Auteur ; Theo G. M. VAN ERP, Auteur . - 2008 . - p.1297-1327. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1297-1327 Index. décimale : PER Périodiques Résumé : Schizophrenia has been thought of as a disorder of reduced functional and structural connectivity. Recent advances in neuroimaging techniques such as functional magnetic resonance imaging, structural magnetic resonance imaging, diffusion tensor imaging, and small animal imaging have advanced our ability to investigate this hypothesis. Moreover, the power of longitudinal designs possible with these noninvasive techniques enable the study of not just how connectivity is disrupted in schizophrenia, but when this disruption emerges during development. This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder. We conclude that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity. En ligne : http://dx.doi.org/10.1017/s095457940800062x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603

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