Greater affective network maturity is associated with better clinical outcomes in women with early sexual trauma / Olena KLESHCHOVA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1458-1468 Titre : Greater affective network maturity is associated with better clinical outcomes in women with early sexual trauma Type de document : Texte imprimé et/ou numérique Auteurs : Olena KLESHCHOVA, Auteur ; Jack GRINBAND, Auteur ; Mariann R. WEIERICH, Auteur Article en page(s) : p.1458-1468 Langues : Anglais (eng) Mots-clés : affective network  brain maturity  machine learning  resting functional connectivity  sexual trauma Index. décimale : PER Périodiques Résumé : Early-life adversity accelerates the maturation of affect-related circuitry, which might be a short-term adaptation with long-term tradeoffs. Sexual trauma is associated with a particularly strong impact on pubertal development and mental health outcomes. Our objective was to test the relations between trauma type, affective network maturity, and mental health outcomes in young women with trauma history. Trauma-exposed women aged 18-29 completed a clinical interview (n = 35) and an fMRI scan (n = 28). We used a public data set to train a machine learning algorithm to predict age from resting-state affective network connectivity and calculated network maturity as the difference between predicted and true age. We also performed principal component analysis on mental health outcomes and retained two components: clinical and state psychological outcomes. Compared to nonsexual trauma (n = 17), sexual trauma (n = 11) was associated with greater affective network maturity. In addition, for sexual trauma only, greater affective network maturity was associated with better clinical but not state psychological outcomes. These results suggest that sexual trauma during development might uniquely alter the maturational trajectory of affect-related circuitry, with distinct mental health consequences in emerging adulthood. Whereas delayed affective network maturation is associated with adverse clinical outcomes, accelerated affective network maturation might confer resilience in survivors. En ligne : https://dx.doi.org/10.1017/S0954579423000676 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Greater affective network maturity is associated with better clinical outcomes in women with early sexual trauma [Texte imprimé et/ou numérique] / Olena KLESHCHOVA, Auteur ; Jack GRINBAND, Auteur ; Mariann R. WEIERICH, Auteur . - p.1458-1468. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1458-1468 Mots-clés : affective network  brain maturity  machine learning  resting functional connectivity  sexual trauma Index. décimale : PER Périodiques Résumé : Early-life adversity accelerates the maturation of affect-related circuitry, which might be a short-term adaptation with long-term tradeoffs. Sexual trauma is associated with a particularly strong impact on pubertal development and mental health outcomes. Our objective was to test the relations between trauma type, affective network maturity, and mental health outcomes in young women with trauma history. Trauma-exposed women aged 18-29 completed a clinical interview (n = 35) and an fMRI scan (n = 28). We used a public data set to train a machine learning algorithm to predict age from resting-state affective network connectivity and calculated network maturity as the difference between predicted and true age. We also performed principal component analysis on mental health outcomes and retained two components: clinical and state psychological outcomes. Compared to nonsexual trauma (n = 17), sexual trauma (n = 11) was associated with greater affective network maturity. In addition, for sexual trauma only, greater affective network maturity was associated with better clinical but not state psychological outcomes. These results suggest that sexual trauma during development might uniquely alter the maturational trajectory of affect-related circuitry, with distinct mental health consequences in emerging adulthood. Whereas delayed affective network maturation is associated with adverse clinical outcomes, accelerated affective network maturation might confer resilience in survivors. En ligne : https://dx.doi.org/10.1017/S0954579423000676 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

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