The BTBR T+ Itpr3tf/J mouse strain as a model to study the genetic, immune, and metabolic origins of neurodevelopmental disorders / M. P. VISCOMI in Research in Autism Spectrum Disorders, 119 (January 2025)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 119 (January 2025) . - p.102526 Titre : The BTBR T+ Itpr3tf/J mouse strain as a model to study the genetic, immune, and metabolic origins of neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : M. P. VISCOMI, Auteur ; J. CZYRSKA, Auteur ; D. WINIARCZYK, Auteur ; M. M. ZI?TEK, Auteur ; S. SAMPINO, Auteur Article en page(s) : p.102526 Langues : Anglais (eng) Mots-clés : Autism  Mouse model  BTBR strain  Metabolism Index. décimale : PER Périodiques Résumé : The BTBR T+ Itpr3tf/J (BTBR) mouse strain manifests a peculiar behavioral phenotype that mirrors the core symptomatology of autism spectrum disorders, including alterations in social-communicative behavioral domains, and the presence of repetitive/stereotyped behaviors. Concurrent immune and metabolic imbalances characterize the BTBR phenotype and are exacerbated by specific gene mutations, resulting in severe multi-organs imbalances that recapitulate the symptoms of human autoimmune and metabolic disorders. The present review aims to retrace and summarize state-of-the-art regarding the genetic, immune, and metabolic features of the BTBR strain and address its potential use as a valid model to study the multi-system etiology and pathogenesis of neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1016/j.rasd.2024.102526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] The BTBR T+ Itpr3tf/J mouse strain as a model to study the genetic, immune, and metabolic origins of neurodevelopmental disorders [Texte imprimé et/ou numérique] / M. P. VISCOMI, Auteur ; J. CZYRSKA, Auteur ; D. WINIARCZYK, Auteur ; M. M. ZI?TEK, Auteur ; S. SAMPINO, Auteur . - p.102526. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 119 (January 2025) . - p.102526 Mots-clés : Autism  Mouse model  BTBR strain  Metabolism Index. décimale : PER Périodiques Résumé : The BTBR T+ Itpr3tf/J (BTBR) mouse strain manifests a peculiar behavioral phenotype that mirrors the core symptomatology of autism spectrum disorders, including alterations in social-communicative behavioral domains, and the presence of repetitive/stereotyped behaviors. Concurrent immune and metabolic imbalances characterize the BTBR phenotype and are exacerbated by specific gene mutations, resulting in severe multi-organs imbalances that recapitulate the symptoms of human autoimmune and metabolic disorders. The present review aims to retrace and summarize state-of-the-art regarding the genetic, immune, and metabolic features of the BTBR strain and address its potential use as a valid model to study the multi-system etiology and pathogenesis of neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1016/j.rasd.2024.102526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

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