The Developmental Autism Early Screening (DAES): A Novel Test for Screening Autism Spectrum Disorder / Lara CIRNIGLIARO ; Maria Stella VALLE ; Antonino CASABONA ; Martina RANDAZZO ; Francesca La Bruna ; Fabio PETTINATO ; Antonio NARZISI ; Renata RIZZO ; Rita BARONE in Journal of Autism and Developmental Disorders, 55-1 (January 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.221-236 Titre : The Developmental Autism Early Screening (DAES): A Novel Test for Screening Autism Spectrum Disorder : Journal of Autism and Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lara CIRNIGLIARO, Auteur ; Maria Stella VALLE, Auteur ; Antonino CASABONA, Auteur ; Martina RANDAZZO, Auteur ; Francesca La Bruna, Auteur ; Fabio PETTINATO, Auteur ; Antonio NARZISI, Auteur ; Renata RIZZO, Auteur ; Rita BARONE, Auteur Article en page(s) : p.221-236 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study was undertaken to set a novel developmental screening test for autism spectrum disorder (ASD) using the Griffiths Scales of Child Development (Griffith III) (Green et al., 2016; Stroud et al., 2016), in order to intercept the early atypical developmental patterns indicating ASD risk in the first 3 years of age. An observational and interactive ASD screener, the Developmental Autism Early Screening (DAES), was developed by detecting Griffiths III items differentiating toddlers with ASD risk from those with global developmental delay (DD) or neurotypical development. The DAES was validated with ASD-specific diagnostic instruments (ADOS-2) and the cut-off score based on sensitivity, specificity and positive predictive value that best differentiates between ASD and non-ASD children was identified. We enrolled a total sample of 297 subjects, including children at risk for ASD or DD and neurotypical children. At a cut-off score of 12.5, the DAES had a sensitivity of 93%, specificity of 98.4%, positive predictive value of 96.3% and negative predictive value of 96.9% for identifying children at risk for ASD from non-ASD participants (DD/neurotypical children). The DAES total score correlated significantly with the ADOS-2 calibrated severity scores (CSS) (R = 0.53, p < 0.001). Three ASD risk ranges were identified according to DAES total and ADOS-2 CSS: Little-to-no risk (CSS: 1-3, DAES: 1-7); Mild-to-moderate risk (CSS: 4-5, DAES: 8-14); Moderate-to-severe risk (CSS: 6-10, DAES???15). The DAES provides a direct approach based on developmental profiles to stratify risk for ASD in early childhood ensuring at risk children the most appropriate diagnostic procedures and targeted intervention. En ligne : https://doi.org/10.1007/s10803-023-06184-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] The Developmental Autism Early Screening (DAES): A Novel Test for Screening Autism Spectrum Disorder : Journal of Autism and Developmental Disorders [Texte imprimé et/ou numérique] / Lara CIRNIGLIARO, Auteur ; Maria Stella VALLE, Auteur ; Antonino CASABONA, Auteur ; Martina RANDAZZO, Auteur ; Francesca La Bruna, Auteur ; Fabio PETTINATO, Auteur ; Antonio NARZISI, Auteur ; Renata RIZZO, Auteur ; Rita BARONE, Auteur . - p.221-236. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.221-236 Index. décimale : PER Périodiques Résumé : This study was undertaken to set a novel developmental screening test for autism spectrum disorder (ASD) using the Griffiths Scales of Child Development (Griffith III) (Green et al., 2016; Stroud et al., 2016), in order to intercept the early atypical developmental patterns indicating ASD risk in the first 3 years of age. An observational and interactive ASD screener, the Developmental Autism Early Screening (DAES), was developed by detecting Griffiths III items differentiating toddlers with ASD risk from those with global developmental delay (DD) or neurotypical development. The DAES was validated with ASD-specific diagnostic instruments (ADOS-2) and the cut-off score based on sensitivity, specificity and positive predictive value that best differentiates between ASD and non-ASD children was identified. We enrolled a total sample of 297 subjects, including children at risk for ASD or DD and neurotypical children. At a cut-off score of 12.5, the DAES had a sensitivity of 93%, specificity of 98.4%, positive predictive value of 96.3% and negative predictive value of 96.9% for identifying children at risk for ASD from non-ASD participants (DD/neurotypical children). The DAES total score correlated significantly with the ADOS-2 calibrated severity scores (CSS) (R = 0.53, p < 0.001). Three ASD risk ranges were identified according to DAES total and ADOS-2 CSS: Little-to-no risk (CSS: 1-3, DAES: 1-7); Mild-to-moderate risk (CSS: 4-5, DAES: 8-14); Moderate-to-severe risk (CSS: 6-10, DAES???15). The DAES provides a direct approach based on developmental profiles to stratify risk for ASD in early childhood ensuring at risk children the most appropriate diagnostic procedures and targeted intervention. En ligne : https://doi.org/10.1007/s10803-023-06184-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

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